epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333/epi.par.con.2024.206epilepsia-1105Research ArticleSCIENTIFIC SURVEYSНАУЧНЫЕ ОБЗОРЫCortical developmental malformations and epilepsyАномалии развития коры головного мозга и эпилепсияhttps://orcid.org/0000-0002-7682-6672МаксимоваМ. Ю.MaksimovaM. Yu.

Максимова Марина Юрьевна, д.м.н., проф 

Волоколамское ш., д. 80, Москва 125367

WoS ResearcherID: C-7408-2012. Scopus Author ID: 7003900736

Marina Yu. Maksimova, Dr. Sci. Med., Prof. 

80 Volokolamskoe Shosse, Moscow 125367

WoS ResearcherID: C-7408-2012. Scopus Author ID: 7003900736

https://orcid.org/0000-0002-4449-8651ТеплышоваА. М.TeplyshovaA. M.

Теплышова Анна Михайловна, к.м.н. 

Волоколамское ш., д. 80, Москва 125367

Anna M. Teplyshova, PhD

80 Volokolamskoe Shosse, Moscow 125367

teplyshova@neurology.ruФедеральное государственное бюджетное научное учреждение «Научный центр неврологии»РоссияResearch Center of NeurologyRussian Federation202422102024163241249Copyright © Maksimova M.Y., Teplyshova A.M., 20242024Максимова М.Ю., Теплышова А.М.Maksimova M.Y., Teplyshova A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/1105

Cortical developmental malformations (CDM) include a large group of heterogeneous brain formation disorders occurring in prenatal period. Current classifications comprise the underlying processes in CDM genesis. The article provides recent conceptions about CDM types such as gray-matter heterotopia and focal cortical dysplasia, which commonly cause epilepsy, often resistant to drug therapy. Rapid advances in improving neuroimaging techniques and molecular genetics in recent years have substantially increased the number of recognized CDM forms.

Аномалии развития коры (АРК) головного мозга включают большую гетерогенную группу нарушений, связанных с формированием головного мозга и возникающих в пренатальном периоде. Актуальные классификации АРК отражают основные патологические процессы, лежащие в основе их развития. В обзоре дается современное представление о таких типах АКР, как гетеротопии серого вещества и фокальные корковые дисплазии, которые являются распространенной причиной эпилепсии, нередко устойчивой к медикаментозной терапии. Стремительный прогресс в совершенствовании методов нейровизуализации и молекулярной генетике в последние годы существенно увеличил количество распознаваемых форм АРК.

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The authors declare that there are no conflicts of interest present.