epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333/epi.par.con.2024.201epilepsia-1144Research ArticleCLINICAL CASESКЛИНИЧЕСКИЕ СЛУЧАИIncreased postictal creatine kinase in epilepsy patientsПостиктальное повышение креатинкиназы у больных эпилепсиейhttps://orcid.org/0000-0001-9988-3525ЛипатоваЛ. В.LipatovaL. V.

Липатова Людмила Валентиновна - д.м.н., проф.

Кондратьевский пр., д. 72 лит. А, Санкт-Петербург, 195271

WoS ResearcherID M-5928-2018, Scopus Author ID 36892509600

Liudmila V. Lipatova - Dr. Sci. Med., Prof.

72 lit. А Kondratievsky Ave., Saint Petersburg, 195271

WoS ResearcherID M-5928-2018, Scopus Author ID 36892509600

l_lipatova@mail.ruhttps://orcid.org/0000-0001-8947-1463СаковскийИ. В.SakovskyI. V.

Саковский Игорь Всеволодович - к.м.н., доцент.

Кондратьевский пр., д. 72 лит. А, Санкт-Петербург, 195271

Igor V. Sakovsky - PhD, Assoc. Prof.

72 lit. А Kondratievsky Ave., Saint Petersburg, 195271

Частное образовательное учреждение высшего образования «Санкт-Петербургский медико-социальный институт»РоссияSaint-Peterburg Medical and Social InstituteRussian Federation202417012025164333337Copyright © Lipatova L.V., Sakovsky I.V., 20252025Липатова Л.В., Саковский И.В.Lipatova L.V., Sakovsky I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/1144

Excessive muscle activity during generalized convulsive seizures in epilepsy patients in some cases can cause significant changes in blood plasma biochemical parameters, increased level of a set of metabolites, particularly, serum creatine kinase, accompanied by azotemia, which leads to prominent diagnostic and therapeutic difficulties. It is necessary to monitor the creatine kinase concentration after seizures, especially in case of electrolyte disturbances. To correct elevated creatine kinase or myoglobin levels, infusion therapy, urine alkalinization along with diuretics administration should be performed.

Избыточная мышечная активность при генерализованных судорожных приступах у больных эпилепсией в ряде случаев может приводить к существенным изменениям биохимических показателей плазмы крови, повышению уровня ряда метаболитов, в частности сывороточной креатинкиназы, сопровождаться азотемией, что вызывает значительные диагностические и терапевтические трудности. Необходимо осуществлять мониторинг концентрации креатинкиназы после судорог, особенно при наличии у пациента электролитных нарушений. Для коррекции повышенного уровня креатинкиназы или миоглобина следует проводить инфузионную терапию, ощелачивание мочи, вводить диуретики.

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The authors declare that there are no conflicts of interest present.