epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333/epi.par.con.2024.208epilepsia-1149Research ArticleSCIENTIFIC SURVEYSНАУЧНЫЕ ОБЗОРЫSystematic analysis of molecular mechanisms of action of essential macro- and micronutrients on the neurotransmitter and vasodilator molecule nitric oxide (NO)Систематический анализ молекулярных механизмов действия эссенциальных макро- и микронутриентов на нейротрансмиттерную и вазодилататорную молекулу оксида азота (NO)https://orcid.org/0000-0002-7663-710XГромоваО. А.GromovaO. A.

Громова Ольга Алексеевна - д.м.н., проф.

ул. Вавилова, д. 44, корп. 2, Москва, 119333

WoS ResearcherID J-4946-2017, Scopus Author ID 7003589812

Olga A. Gromova - Dr. Sci. Med., Prof.

44 corp. 2 Vavilov Str., Moscow, 119333

WoS ResearcherID J-4946-2017, Scopus Author ID 7003589812

unesco.gromova@gmail.comhttps://orcid.org/0000-0002-2659-7998ТоршинИ. Ю.TorshinI. Yu.

Торшин Иван Юрьевич - к.ф-м.н., к.х.н.

ул. Вавилова, д. 44, корп. 2, Москва, 119333

WoS ResearcherID C-7683-2018, Scopus Author ID 7003300274

Ivan Yu. Torshin - PhD.

44 corp. 2 Vavilov Str., Moscow, 119333

WoS ResearcherID C-7683-2018, Scopus Author ID 7003300274

Федеральный исследовательский центр «Информатика и управление» Российской академии наукРоссияFederal Research Center “Computer Science and Control”, Russian Academy of SciencesRussian Federation202418012025164385401Copyright © Gromova O.A., Torshin I.Y., 20252025Громова О.А., Торшин И.Ю.Gromova O.A., Torshin I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/1149

Maintaining adequate levels of nitric oxide (NO) in the blood and other body tissues is necessary for the regulation of vascular tone, blood pressure, maintenance of oxygen metabolism and endothelial function. NO is also involved in regulating the balance of excitatory (glutamate) and inhibitory (gamma-aminobutyric acid) neurotransmission. Nutritional factors profoundly affect NO metabolism. Systematic computer analysis of 26,103 publications by methods of topological approach to recognition allowed to identify the most crucial fields of clinical research assessing relationships between NO metabolism and nutrients: arginine-derived NO synthase-driven NO production, nitrate-containing products, folates and vitamin B12 in NO homeostasis (including the effects of modifications of the vitamin B12 molecule), other B vitamins (B1, B2, B7), antioxidant vitamins (C and E), hormone-like vitamins D3 and A, electrolytes magnesium and calcium, participation of the microbiome in NO production.

Поддержание надлежащих уровней оксида азота (NO) в крови и других тканях организма необходимо для регуляции тонуса сосудов, артериального давления, обеспечения обмена кислорода и функции эндотелия. NO также участвует в регуляции баланса возбуждающей (глутамат) и тормозящей (гамма-аминомасляная кислота) нейротрансмиссии. Нутриентные факторы оказывают существенное влияние на обмен NO. Систематический компьютерный анализ 26 103 публикаций с применением топологического подхода к распознаванию позволил выделить наиболее важные направления клинических исследований взаимосвязей между обменом NO и нутриентами: выработка NO из аргинина посредством NO-синтетазы, нитратосодержащие продукты, фолаты и витамин В12 в гомеостазе NO (включая эффекты модификаций молекулы витамина В12), другие витамины группы В (В1, В2, В7), витамины-антиоксиданты (С и Е), гормоноподобные витамины D3 и А, электролиты магний и кальций, участие микробиома в выработке NO.

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