References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2024.210

epilepsia-1150

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development

Гипотезы развития и стратегии преодоления фармакорезистентности при эпилепсии. Часть I: Гипотезы развития

https://orcid.org/0009-0006-0479-126X

Якимов

А. М.

Yakimov

A. M.

Якимов Алексей Михайлович.

ул. Партизана Железняка, д. 1, Красноярск, 660022

WoS ResearcherID AEW-9605-2022, Scopus Author ID 58161933100

Alexey M. Yakimov.

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022

WoS ResearcherID AEW-9605-2022, Scopus Author ID 58161933100

https://orcid.org/0000-0002-4555-7457

Тимечко

Е. Е.

Timechko

E. E.

Тимечко Елена Евгеньевна.

ул. Партизана Железняка, д. 1, Красноярск, 660022

WoS ResearcherID CAF-2677-2022

Elena E. Timechko.

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022

WoS ResearcherID CAF-2677-2022

https://orcid.org/0000-0002-9394-2413

Парамонова

А. И.

Paramonova

A. I.

Парамонова Анастасия Ивановна.

ул. Партизана Железняка, д. 1, Красноярск, 660022

WoS ResearcherID HMP-3496-2023

Anastasia I. Paramonova.

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022

WoS ResearcherID HMP-3496-2023

https://orcid.org/0009-0008-3369-1537

Васильева

А. A.

Vasilieva

A. A.

Васильева Анастасия Александровна.

ул. Партизана Железняка, д. 1, Красноярск, 660022

Anastasia A. Vasilieva.

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022

https://orcid.org/0009-0006-4391-2669

Рыбаченко

Ф. К.

Rybachenko

F. K.

Рыбаченко Фёдор Константинович.

ул. Партизана Железняка, д. 1, Красноярск, 660022

Fedor K. Rybachenko.

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022

https://orcid.org/0009-0004-1108-6249

Рыбаченко

А. Д.

Rybachenko

A. D.

Рыбаченко Анастасия Дмитриевна.

ул. Партизана Железняка, д. 1, Красноярск, 660022

Anastasia D. Rybachenko.

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022

https://orcid.org/0000-0003-4639-6365

Дмитренко

Д. В.

Dmitrenko

D. V.

Дмитренко Диана Викторовна - д.м.н.

ул. Партизана Железняка, д. 1, Красноярск, 660022

WoS ResearcherID H-7787-2016

Diana V. Dmitrenko - Dr. Sci. Med.

1 Partizan Zheleznyak Str., Krasnoyarsk, 660022

WoS ResearcherID H-7787-2016

mart2802@yandex.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияVoino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation

2024

18012025

164375384

2025

Якимов А.М., Тимечко Е.Е., Парамонова А.И., Васильева А.A., Рыбаченко Ф.К., Рыбаченко А.Д., Дмитренко Д.В.

Yakimov A.M., Timechko E.E., Paramonova A.I., Vasilieva A.A., Rybachenko F.K., Rybachenko A.D., Dmitrenko D.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/1150

Currently, the problem of effective therapy for drug-resistant epilepsy remains vastly relevant. The severity of drug-resistant epilepsy, remarkable negative social sequelae and sudden death in epilepsy pose a heavy burden on healthcare system. Although many innovative antiepileptic drugs have been developed in recent decades, surgical approach remains the only effective way to treat drug-resistant epilepsy which is coupled to significant health risks and does not guarantee freedom from seizures. The stumbling block in managing this pathology is the lack of knowledge on pathogenetic mechanisms, leaving a significant proportion of patients without quality medical care. There are different viewpoints on developing drug resistance in epilepsy, which are characterized by multilayered and overlapping molecular disease bases. The review presents the analysis of the existing hypotheses regarding the mechanisms underlying drug resistance development in epilepsy.

В настоящее время проблема эффективной терапии фармакорезистентной эпилепсии остается крайне актуальной. Тяжесть фармакорезистентной эпилепсии, значительные негативные социальные последствия и внезапная смерть при эпилепсии ложатся тяжелым грузом на институт здравоохранения. Хотя за последние десятилетия было разработано множество инновационных противоэпилептических препаратов, единственным эффективным способом лечения фармакорезистентной эпилепсии остается хирургический подход, сопряженный со значительными рисками для здоровья и не гарантирующий при этом свободу от приступов. Камнем преткновения при преодолении данной патологии является недостаток знаний патогенетических механизмов, оставляющий значительную часть больных без качественной медицинской помощи. Различные взгляды на формирование фармакорезистентности при эпилепсии характеризуются комплексностью и наличием пересекающихся молекулярных основ заболевания. В настоящем обзоре проведен анализ существующих концепций о механизмах развития фармакорезистентности при эпилепсии.

Фармакорезистентная эпилепсиямеханизмы фармакорезистентностиP-гликопротеинканалопатиинейровоспалениенейронная сеть

Drug-resistant epilepsydrug resistance mechanismsP-glycoproteinchannelopathiesneuroinflammationneural network

Обзор подготовлен в рамках госзадания «Идентификация предикторов фармакорезистентного течения и исходов хирургического лечения эпилепсии» (№ 1023022100003-4)

The review was conducted within the framework of the state task "Identification of predictors for pharmacoresistant course and outcomes of surgical treatment of epilepsy" (No. 1023022100003-4)

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The authors declare that there are no conflicts of interest present.