<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2077-8333/epi.par.con.2025.222</article-id><article-id custom-type="elpub" pub-id-type="custom">epilepsia-1176</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC SURVEYS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>Phantom pain: epidemiology and etiopathogenesis</article-title><trans-title-group xml:lang="ru"><trans-title>Фантомные боли: эпидемиология и этиопатогенез</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0459-0488</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корабельников</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Korabelnikov</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корабельников Даниил Иванович, к.м.н., доцент, проф.</p><p>Scopus Author ID: 7801382184. </p><p>ул. 2-я Брестская, д. 5, Москва 123056 </p><p>ул. Маштакова, д. 4, Подольск 142110 </p></bio><bio xml:lang="en"><p>Daniil I. Korabelnikov, PhD, Assoc. Prof., Prof.</p><p>Scopus Author ID: 7801382184. </p><p>5 2nd Brestskaya Str., Moscow 123056; 4 Mashtakov Str., Podolsk 142110.</p></bio><email xlink:type="simple">dkorabelnikov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-4123-4649</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткаченко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachenko</surname><given-names>Е. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ткаченко Евгений Валентинович</p><p>ул. 2-я Брестская, д. 5, Москва 123056; Госпитальная пл., д. 3, Москва 105094.</p></bio><bio xml:lang="en"><p>Evgeny V. Tkachenko </p><p>5 2nd Brestskaya Str., Moscow 123056; 3 Gospitalnaya Sq., Moscow 105094.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0483-1050</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Магомедалиев</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Magomedaliev</surname><given-names>M. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Магомедалиев Магомедали Омарасхабович</p><p>Scopus Author ID: 58284748000.</p><p>ул. 2-я Брестская, д. 5, Москва 123056; ул. Маштакова, д. 4, Подольск 142110.</p></bio><bio xml:lang="en"><p>Magomedali O. Magomedaliev</p><p>Scopus Author ID: 58284748000. </p><p>5 2nd Brestskaya Str., Moscow 123056; 4 Mashtakov Str., Podolsk 142110.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Автономная некоммерческая организация дополнительного профессионального образования «Московский медико-социальный институт им. Ф.П. Гааза» ; Федеральное государственное казенное учреждение «1586 Военный клинический госпиталь» Министерства обороны Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Haass Medical Social Institute; 1586 Military Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Автономная некоммерческая организация дополнительного профессионального образования «Московский медико-социальный институт им. Ф.П. Гааза» ; Федеральное государственное бюджетное учреждение «Главный военный клинический госпиталь им. академика Н.Н. Бурденко» Министерства обороны Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Haass Medical Social Institute; Burdenko Main Military Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>02</day><month>05</month><year>2025</year></pub-date><volume>17</volume><issue>1</issue><fpage>82</fpage><lpage>93</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Korabelnikov D.I., Tkachenko Е.V., Magomedaliev M.O., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Корабельников Д.И., Ткаченко Е.В., Магомедалиев М.О.</copyright-holder><copyright-holder xml:lang="en">Korabelnikov D.I., Tkachenko Е.V., Magomedaliev M.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/1176">https://www.epilepsia.su/jour/article/view/1176</self-uri><abstract><p>Phantom pain (PP) represents a pathological pain sensation that emerges in a person regarding a body part lost due to amputation or even naturally absent. PP occurs after amputation of both upper and lower limbs and can significantly impair patient's quality of life. Although PP descriptions have been reported since the 16th century, the precise underlying causes and pathogenesis remain obscure. Several factors, such as the site of amputation and the presence of pre-surgery pain, are associated with PP development. There are continued discussions regarding a role played by the central and peripheral nervous systems in arising PP, so that a relation between the former and neural network rewiring remain debated. The current review assesses PP epidemiology, as well as various theories behind its pathogenesis. In this context, publications included in the scientometric databases PubMed/MEDLINE, Scopus, Web of Science, Embase, and eLibrary were analyzed.</p></abstract><trans-abstract xml:lang="ru"><p>Фантомная боль (ФБ) представляет собой патологическое болевое ощущение, возникающее у человека в отношении части тела, которая была утрачена в результате ампутации или даже изначально отсутствовала. ФБ возникает после ампутации как верхних, так и нижних конечностей и может значительно ухудшать качество жизни пациента. Хотя описания ФБ встречаются с XVI века, точные причины и патогенез этого явления до сих пор не установлены. Некоторые факторы, такие как место ампутации и наличие боли перед операцией, связаны с развитием ФБ. Продолжаются дискуссии о роли центральной и периферической нервных систем в возникновении ФБ, а также обсуждается связь последних с реорганизацией нейронной сети. В обзоре рассматриваются эпидемиология, а также различные теории патогенеза ФБ. Выполнен анализ источников, включенных в наукометрические базы PubMed/MEDLINE, Scopus, Web of Science, Embase и eLibrary.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фантомная конечность</kwd><kwd>фантомная боль</kwd><kwd>фантомно-болевой синдром</kwd><kwd>этиология</kwd><kwd>патогенез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>phantom limb</kwd><kwd>phantom pain</kwd><kwd>etiology</kwd><kwd>pathogenesis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hanyu-Deutmeyer A.A., Cascella M., Varacallo M. Phantom limb pain. Treasure Island (FL): StatPearls Publishing; 2025 Jan.</mixed-citation><mixed-citation xml:lang="en">Hanyu-Deutmeyer A.A., Cascella M., Varacallo M. Phantom limb pain. Treasure Island (FL): StatPearls Publishing; 2025 Jan.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ramachandran V., Hirstein W. The perception of phantom limbs. The D.O. Hebb lecture. Brain. 1998; 121 (9): 1603–30. https://doi.org/10.1093/brain/121.9.1603.</mixed-citation><mixed-citation xml:lang="en">Ramachandran V., Hirstein W. The perception of phantom limbs. The D.O. Hebb lecture. Brain. 1998; 121 (9): 1603–30. https://doi.org/10.1093/brain/121.9.1603.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Schone H.R., Baker C.I., Katz J., et al. Making sense of phantom limb pain. J Neurol Neurosurg Psychiatry. 2022; 93 (8): 833–43. https://doi.org/10.1136/jnnp-2021-328428.</mixed-citation><mixed-citation xml:lang="en">Schone H.R., Baker C.I., Katz J., et al. Making sense of phantom limb pain. J Neurol Neurosurg Psychiatry. 2022; 93 (8): 833–43. https://doi.org/10.1136/jnnp-2021-328428.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Arizona P., Yulianti E., Fithriyah I. Psychiatric approach in phantom erection postpenectomy patient. Case Rep Psychiatry. 2023; 2023: 4113455. https://doi.org/10.1155/2023/4113455.</mixed-citation><mixed-citation xml:lang="en">Arizona P., Yulianti E., Fithriyah I. Psychiatric approach in phantom erection postpenectomy patient. Case Rep Psychiatry. 2023; 2023: 4113455. https://doi.org/10.1155/2023/4113455.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Limakatso K., Bedwell G.J., Madden V.J., Parker R. The prevalence and risk factors for phantom limb pain in people with amputations: a systematic review and meta-analysis. PLoS One. 2020; 15 (10): e0240431. https://doi.org/10.1371/journal.pone.0240431.</mixed-citation><mixed-citation xml:lang="en">Limakatso K., Bedwell G.J., Madden V.J., Parker R. The prevalence and risk factors for phantom limb pain in people with amputations: a systematic review and meta-analysis. PLoS One. 2020; 15 (10): e0240431. https://doi.org/10.1371/journal.pone.0240431.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральные клинические рекомендации по предотвращению фантомного болевого синдрома при ампутации конечности. 2014. URL: https://goo.su/Bmz0A (дата обращения 26.11.2024).</mixed-citation><mixed-citation xml:lang="en">Federal clinical guidelines for the prevention of phantom pain syndrome in limb amputation. 2014. Available at: https://goo.su/Bmz0A (in Russ.) (accessed 26.11.2024).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Раимкулов Б.Н., Раимкулова К.Б., Раимкулова Х.Б. и др. Общая характеристика боли. Механизм развития боли (обзор литературы). Вестник Казахского национального медицинского университета. 2016; 2: 324–7.</mixed-citation><mixed-citation xml:lang="en">Raimkulov B.N., Raimkulova K.B., Raimkulova H.B., et al. General characteristics of pain. Mechanism of pain development (literature review). Bulletin of the Kazakh National Medical University. 2016; 2: 324–7 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kaur A., Guan Y. Phantom limb pain: a literature review. Chin J Traumatol. 2018; 21 (6): 366–8. https://doi.org/10.1016/j.cjtee.2018.04.006.</mixed-citation><mixed-citation xml:lang="en">Kaur A., Guan Y. Phantom limb pain: a literature review. Chin J Traumatol. 2018; 21 (6): 366–8. https://doi.org/10.1016/j.cjtee.2018.04.006.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Корабельников Д.И., Ткаченко Е.В., Магомедалиев М.О. Фантомы и фантомные конечности: история описания феномена. Эпилепсия и пароксизмальные состояния. 2024; 16 (4): 409–16. https://doi.org/10.17749/2077-8333/epi.par.con.2024.219.</mixed-citation><mixed-citation xml:lang="en">Korabelnikov D.I., Tkachenko E.V., Magomedaliev M.O. Phantoms and phantom limbs: history of describing the phenomenon. Epilepsia i paroksizmal'nye sostoania / Epilepsy and Paroxysmal Conditions. 2024; 16 (4): 409–16 (in Russ.). https://doi.org/10.17749/2077-8333/epi.par.con.2024.219.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Limakatso K., Ndhlovu F., Usenbo A., et al. The prevalence and risk factors for phantom limb pain: a cross-sectional survey. BMC Neurol. 2024; 24 (1): 57. https://doi.org/10.1186/s12883-024-03547-w.</mixed-citation><mixed-citation xml:lang="en">Limakatso K., Ndhlovu F., Usenbo A., et al. The prevalence and risk factors for phantom limb pain: a cross-sectional survey. BMC Neurol. 2024; 24 (1): 57. https://doi.org/10.1186/s12883-024-03547-w.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Priyadharshan K.P., Kumar N., Shanmugam D., et al. Quality of life in lower limb amputees: a cross-sectional study from a tertiary care center of South India. Prosthet Orthot Int. 2022; 46 (3): 246–51. https://doi.org/10.1097/PXR.0000000000000108.</mixed-citation><mixed-citation xml:lang="en">Priyadharshan K.P., Kumar N., Shanmugam D., et al. Quality of life in lower limb amputees: a cross-sectional study from a tertiary care center of South India. Prosthet Orthot Int. 2022; 46 (3): 246–51. https://doi.org/10.1097/PXR.0000000000000108.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Schley M.T., Wilms P., Toepfner S., et al. Painful and nonpainful phantom and stump sensations in acute traumatic amputees. J Trauma. 2008; 65 (4): 858–64. https://doi.org/10.1097/TA.0b013e31812eed9e.</mixed-citation><mixed-citation xml:lang="en">Schley M.T., Wilms P., Toepfner S., et al. Painful and nonpainful phantom and stump sensations in acute traumatic amputees. J Trauma. 2008; 65 (4): 858–64. https://doi.org/10.1097/TA.0b013e31812eed9e.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Curelli A., Brouard M., Antoine P. Role of psychological factors in post-amputation phantom pain and phantom sensations. Douleurs: Evaluation – Diagnostic – Traitement. 2007; 8 (2): 65–72 (in French). https://doi.org/10.1016/S1624-5687(07)88795-6.</mixed-citation><mixed-citation xml:lang="en">Curelli A., Brouard M., Antoine P. Role of psychological factors in post-amputation phantom pain and phantom sensations. Douleurs: Evaluation – Diagnostic – Traitement. 2007; 8 (2): 65–72 (in French). https://doi.org/10.1016/S1624-5687(07)88795-6.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed A., Bhatnagar S., Mishra S., et al. Prevalence of phantom limb pain, stump pain, and phantom limb sensation among the amputated cancer patients in India: a prospective, observational study. Indian J Palliat Care. 2017; 23 (1): 24–35. https://doi.org/10.4103/0973-1075.197944.</mixed-citation><mixed-citation xml:lang="en">Ahmed A., Bhatnagar S., Mishra S., et al. Prevalence of phantom limb pain, stump pain, and phantom limb sensation among the amputated cancer patients in India: a prospective, observational study. Indian J Palliat Care. 2017; 23 (1): 24–35. https://doi.org/10.4103/0973-1075.197944.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rahimi A., Mousavi B., Soroush M., et al. Pain and health-related quality of life in war veterans with bilateral lower limb amputations. Trauma Mon. 2012; 17 (2): 282–6. https://doi.org/10.5812/traumamon.5135.</mixed-citation><mixed-citation xml:lang="en">Rahimi A., Mousavi B., Soroush M., et al. Pain and health-related quality of life in war veterans with bilateral lower limb amputations. Trauma Mon. 2012; 17 (2): 282–6. https://doi.org/10.5812/traumamon.5135.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bekrater-Bodmann R., Schredl M., Diers M., et al. Post-amputation pain is associated with the recall of an impaired body representation in dreams – results from a nation-wide survey on limb amputees. PLoS One. 2015; 10 (3): e0119552. https://doi.org/10.1371/journal.pone.0119552.</mixed-citation><mixed-citation xml:lang="en">Bekrater-Bodmann R., Schredl M., Diers M., et al. Post-amputation pain is associated with the recall of an impaired body representation in dreams – results from a nation-wide survey on limb amputees. PLoS One. 2015; 10 (3): e0119552. https://doi.org/10.1371/journal.pone.0119552.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ayaz S.B., Ikram M., Matee S., et al. Frequency and the related sociodemographic and clinical factors of phantom limb pain in traumatic amputees presenting at a tertiary care rehabilitation setup: phantom limb pain in traumatic amputees. Pakistan Armed Forces Med J. 2015; 65 (6): 782–8.</mixed-citation><mixed-citation xml:lang="en">Ayaz S.B., Ikram M., Matee S., et al. Frequency and the related sociodemographic and clinical factors of phantom limb pain in traumatic amputees presenting at a tertiary care rehabilitation setup: phantom limb pain in traumatic amputees. Pakistan Armed Forces Med J. 2015; 65 (6): 782–8.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Byrne K.P.A. Survey of phantom limb pain, phantom sensation and stump pain in Cambodian and New Zealand amputees. Pain Med. 2011; 12 (5): 794–8. https://doi.org/10.1111/j.1526-4637.2011.01105.x.</mixed-citation><mixed-citation xml:lang="en">Byrne K.P.A. Survey of phantom limb pain, phantom sensation and stump pain in Cambodian and New Zealand amputees. Pain Med. 2011; 12 (5): 794–8. https://doi.org/10.1111/j.1526-4637.2011.01105.x.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Clark R.L., Bowling F.L., Jepson F., Rajbhandari S. Phantom limb pain after amputation in diabetic patients does not differ from that after amputation in nondiabetic patients. Pain. 2013; 154 (5): 729–32. https://doi.org/10.1016/j.pain.2013.01.009.</mixed-citation><mixed-citation xml:lang="en">Clark R.L., Bowling F.L., Jepson F., Rajbhandari S. Phantom limb pain after amputation in diabetic patients does not differ from that after amputation in nondiabetic patients. Pain. 2013; 154 (5): 729–32. https://doi.org/10.1016/j.pain.2013.01.009.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Datta D., Selvarajah K., Davey N. Functional outcome of patients with proximal upper limb deficiency – acquired and congenital. Clin Rehabil. 2004; 18 (2): 172–7. https://doi.org/10.1191/0269215504cr716oa.</mixed-citation><mixed-citation xml:lang="en">Datta D., Selvarajah K., Davey N. Functional outcome of patients with proximal upper limb deficiency – acquired and congenital. Clin Rehabil. 2004; 18 (2): 172–7. https://doi.org/10.1191/0269215504cr716oa.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Desmond D.M., MacLachlan M. Prevalence and characteristics of phantom limb pain and residual limb pain in the long term after upper limb amputation. Int J Rehabil Res. 2010; 33 (3): 279–82. https://doi.org/10.1097/MRR.0b013e328336388d.</mixed-citation><mixed-citation xml:lang="en">Desmond D.M., MacLachlan M. Prevalence and characteristics of phantom limb pain and residual limb pain in the long term after upper limb amputation. Int J Rehabil Res. 2010; 33 (3): 279–82. https://doi.org/10.1097/MRR.0b013e328336388d.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Dijkstra P.U., Geertzen J.H.B., Stewart R., van der Schans C.P. Phantom pain and risk factors: a multivariate analysis. J Pain Symptom Manage. 2002; 24 (6): 578–85. https://doi.org/10.1016/S0885-3924(02)00538-9.</mixed-citation><mixed-citation xml:lang="en">Dijkstra P.U., Geertzen J.H.B., Stewart R., van der Schans C.P. Phantom pain and risk factors: a multivariate analysis. J Pain Symptom Manage. 2002; 24 (6): 578–85. https://doi.org/10.1016/S0885-3924(02)00538-9.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ehde D.M., Czerniecki J.M., Smith D.G., et al. Chronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputation. Arch Phys Med Rehabil. 2000; 81 (8): 1039–44. https://doi.org/10.1053/apmr.2000.7583.</mixed-citation><mixed-citation xml:lang="en">Ehde D.M., Czerniecki J.M., Smith D.G., et al. Chronic phantom sensations, phantom pain, residual limb pain, and other regional pain after lower limb amputation. Arch Phys Med Rehabil. 2000; 81 (8): 1039–44. https://doi.org/10.1053/apmr.2000.7583.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ephraim P.L., Wegener S.T., MacKenzie E.J., et al. Phantom pain, residual limb pain, and back pain in amputees: results of a national survey. Arch Phys Med Rehabil. 2005; 86 (10): 1910–9. https://doi.org/10.1016/j.apmr.2005.03.031.</mixed-citation><mixed-citation xml:lang="en">Ephraim P.L., Wegener S.T., MacKenzie E.J., et al. Phantom pain, residual limb pain, and back pain in amputees: results of a national survey. Arch Phys Med Rehabil. 2005; 86 (10): 1910–9. https://doi.org/10.1016/j.apmr.2005.03.031.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gallagher P., Allen D., Maclachlan M. Phantom limb pain and residual limb pain following lower limb amputation: a descriptive analysis. Disabil Rehabil. 2001; 23 (12): 522–30. https://doi.org/10.1080/09638280010029859.</mixed-citation><mixed-citation xml:lang="en">Gallagher P., Allen D., Maclachlan M. Phantom limb pain and residual limb pain following lower limb amputation: a descriptive analysis. Disabil Rehabil. 2001; 23 (12): 522–30. https://doi.org/10.1080/09638280010029859.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hanley M.A., Ehde D.M., Campbell K.M., et al. Self-reported treatments used for lower-limb phantom pain: descriptive findings. Arch Phys Med Rehabil. 2006; 87 (2): 270–7. https://doi.org/10.1016/j.apmr.2005.04.025.</mixed-citation><mixed-citation xml:lang="en">Hanley M.A., Ehde D.M., Campbell K.M., et al. Self-reported treatments used for lower-limb phantom pain: descriptive findings. Arch Phys Med Rehabil. 2006; 87 (2): 270–7. https://doi.org/10.1016/j.apmr.2005.04.025.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hanley M.A., Ehde D.M., Jensen M., et al. Chronic pain associated with upper-limb loss. Am J Phys Med Rehabil. 2009; 88 (9): 742–51. https://doi.org/10.1097/PHM.0b013e3181b306ec.</mixed-citation><mixed-citation xml:lang="en">Hanley M.A., Ehde D.M., Jensen M., et al. Chronic pain associated with upper-limb loss. Am J Phys Med Rehabil. 2009; 88 (9): 742–51. https://doi.org/10.1097/PHM.0b013e3181b306ec.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hnoosh A.H. Phantom limb and pain after traumatic lower extremity amputation. J Fac Med Bagdad. 2014; 56 (1): 57–61. https://doi.org/10.32007/jfacmedbagdad.561427.</mixed-citation><mixed-citation xml:lang="en">Hnoosh A.H. Phantom limb and pain after traumatic lower extremity amputation. J Fac Med Bagdad. 2014; 56 (1): 57–61. https://doi.org/10.32007/jfacmedbagdad.561427.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Houghton A.D., Nicholls G., Houghton A.L., et al. Phantom pain: natural history and association with rehabilitation. Ann R Coll Surg Engl. 1994; 76 (1): 22–5.</mixed-citation><mixed-citation xml:lang="en">Houghton A.D., Nicholls G., Houghton A.L., et al. Phantom pain: natural history and association with rehabilitation. Ann R Coll Surg Engl. 1994; 76 (1): 22–5.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kern U., Busch V., Müller R., et al. Phantom limb pain in daily practice – still a lot of work to do! Pain Med. 2012; 13 (12): 1611–26. https://doi.org/10.1111/j.1526-4637.2012.01494.x.</mixed-citation><mixed-citation xml:lang="en">Kern U., Busch V., Müller R., et al. Phantom limb pain in daily practice – still a lot of work to do! Pain Med. 2012; 13 (12): 1611–26. https://doi.org/10.1111/j.1526-4637.2012.01494.x.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ketz A.K. The experience of phantom limb pain in patients with combat-related traumatic amputations. Arch Phys Med Rehabil. 2008; 89 (6): 1127–32. https://doi.org/10.1016/j.apmr.2007.11.037.</mixed-citation><mixed-citation xml:lang="en">Ketz A.K. The experience of phantom limb pain in patients with combat-related traumatic amputations. Arch Phys Med Rehabil. 2008; 89 (6): 1127–32. https://doi.org/10.1016/j.apmr.2007.11.037.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kooijman C.M., Dijkstra P.U., Geertzen J.H.B., et al. Phantom pain and phantom sensations in upper limb amputees: an epidemiological study. Pain. 2000; 87 (1): 33–41. https://doi.org/10.1016/S0304-3959(00)00264-5.</mixed-citation><mixed-citation xml:lang="en">Kooijman C.M., Dijkstra P.U., Geertzen J.H.B., et al. Phantom pain and phantom sensations in upper limb amputees: an epidemiological study. Pain. 2000; 87 (1): 33–41. https://doi.org/10.1016/S0304-3959(00)00264-5.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Larbig W., Andoh J., Huse E., et al. Pre- and postoperative predictors of phantom limb pain. Neurosci Lett. 2019; 702: 44–50. https://doi.org/10.1016/j.neulet.2018.11.044.</mixed-citation><mixed-citation xml:lang="en">Larbig W., Andoh J., Huse E., et al. Pre- and postoperative predictors of phantom limb pain. Neurosci Lett. 2019; 702: 44–50. https://doi.org/10.1016/j.neulet.2018.11.044.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Morgan S.J., Friedly J.L., Amtmann D., et al. Cross-sectional assessment of factors related to pain intensity and pain interference in lower limb prosthesis users. Arch Phys Med Rehabil. 2017; 98 (1): 105–13. https://doi.org/10.1016/j.apmr.2016.09.118.</mixed-citation><mixed-citation xml:lang="en">Morgan S.J., Friedly J.L., Amtmann D., et al. Cross-sectional assessment of factors related to pain intensity and pain interference in lower limb prosthesis users. Arch Phys Med Rehabil. 2017; 98 (1): 105–13. https://doi.org/10.1016/j.apmr.2016.09.118.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Noguchi S., Saito J., Nakai K., et al. Factors affecting phantom limb pain in patients undergoing amputation: retrospective study. J Anesth. 2019; 33 (2): 216–20. https://doi.org/10.1007/s00540-018-2599-0.</mixed-citation><mixed-citation xml:lang="en">Noguchi S., Saito J., Nakai K., et al. Factors affecting phantom limb pain in patients undergoing amputation: retrospective study. J Anesth. 2019; 33 (2): 216–20. https://doi.org/10.1007/s00540-018-2599-0.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Probstner D., Thuler L.C., Ishikawa N.M., Alvarenga R.M. Phantom limb phenomena in cancer amputees: phantom limb phenomena in cancer amputees. Pain Pract. 2010; 10 (3): 249–56. https://doi.org/10.1111/j.1533-2500.2009.00340.x.</mixed-citation><mixed-citation xml:lang="en">Probstner D., Thuler L.C., Ishikawa N.M., Alvarenga R.M. Phantom limb phenomena in cancer amputees: phantom limb phenomena in cancer amputees. Pain Pract. 2010; 10 (3): 249–56. https://doi.org/10.1111/j.1533-2500.2009.00340.x.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Rafferty M., Bennett Britton T.M., Drew B.T., Phillip R.D. Crosssectional study of alteration of phantom limb pain with visceral stimulation in military personnel with amputation. J Rehabil Res Dev. 2015; 52 (4): 441–8. https://doi.org/10.1682/JRRD.2014.04.0114.</mixed-citation><mixed-citation xml:lang="en">Rafferty M., Bennett Britton T.M., Drew B.T., Phillip R.D. Crosssectional study of alteration of phantom limb pain with visceral stimulation in military personnel with amputation. J Rehabil Res Dev. 2015; 52 (4): 441–8. https://doi.org/10.1682/JRRD.2014.04.0114.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Razmus M., Daniluk B., Markiewicz P. Phantom limb phenomenon as an example of body image distortion. Curr Probl Psychiatry. 2017; 18 (2): 153–9. https://doi.org/10.1515/cpp-2017-0013.</mixed-citation><mixed-citation xml:lang="en">Razmus M., Daniluk B., Markiewicz P. Phantom limb phenomenon as an example of body image distortion. Curr Probl Psychiatry. 2017; 18 (2): 153–9. https://doi.org/10.1515/cpp-2017-0013.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Reiber G.E., McFarland L.V., Hubbard S., et al. Servicemembers and veterans with major traumatic limb loss from Vietnam war and OIF/ OEF conflicts: survey methods, participants, and summary findings. J Rehabil Res Dev. 2010; 47 (4): 275–97. https://doi.org/10.1682/jrrd.2010.01.0009.</mixed-citation><mixed-citation xml:lang="en">Reiber G.E., McFarland L.V., Hubbard S., et al. Servicemembers and veterans with major traumatic limb loss from Vietnam war and OIF/ OEF conflicts: survey methods, participants, and summary findings. J Rehabil Res Dev. 2010; 47 (4): 275–97. https://doi.org/10.1682/jrrd.2010.01.0009.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Balk E.M., Gazula A., Markozannes G., et al. Psychometric properties of functional, ambulatory, and quality of life instruments in lower limb amputees: a systematic review. Arch Phys Med Rehabil. 2019; 100 (12): 2354–70. https://doi.org/10.1016/j.apmr.2019.02.015.</mixed-citation><mixed-citation xml:lang="en">Balk E.M., Gazula A., Markozannes G., et al. Psychometric properties of functional, ambulatory, and quality of life instruments in lower limb amputees: a systematic review. Arch Phys Med Rehabil. 2019; 100 (12): 2354–70. https://doi.org/10.1016/j.apmr.2019.02.015.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Richardson C., Glenn S., Horgan M., Nurmikko T. A prospective study of factors associated with the presence of phantom limb pain six months after major lower limb amputation in patients with peripheral vascular disease. J Pain. 2007; 8 (10): 793–801. https://doi.org/10.1016/j.jpain.2007.05.007.</mixed-citation><mixed-citation xml:lang="en">Richardson C., Glenn S., Horgan M., Nurmikko T. A prospective study of factors associated with the presence of phantom limb pain six months after major lower limb amputation in patients with peripheral vascular disease. J Pain. 2007; 8 (10): 793–801. https://doi.org/10.1016/j.jpain.2007.05.007.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Richardson C., Crawford K., Milnes K., et al. A clinical evaluation of postamputation phenomena including phantom limb pain after lower limb amputation in dysvascular patients. Pain Manag Nurs. 2015; 16 (4): 561–9. https://doi.org/10.1016/j.pmn.2014.10.006.</mixed-citation><mixed-citation xml:lang="en">Richardson C., Crawford K., Milnes K., et al. A clinical evaluation of postamputation phenomena including phantom limb pain after lower limb amputation in dysvascular patients. Pain Manag Nurs. 2015; 16 (4): 561–9. https://doi.org/10.1016/j.pmn.2014.10.006.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Wartan S.W., Hamann W., Wedley J.R., McColl I. Phantom pain and sensation among British veteran amputees. Br J Anaesth. 1997; 78 (6): 652–9. https://doi.org/10.1093/bja/78.6.652.</mixed-citation><mixed-citation xml:lang="en">Wartan S.W., Hamann W., Wedley J.R., McColl I. Phantom pain and sensation among British veteran amputees. Br J Anaesth. 1997; 78 (6): 652–9. https://doi.org/10.1093/bja/78.6.652.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Yin Y., Zhang L., Xiao H., et al. The pre-amputation pain and the postoperative deafferentation are the risk factors of phantom limb pain: a clinical survey in a sample of Chinese population. BMC Anesthesiol. 2017; 17 (1): 69. https://doi.org/10.1186/s12871-017-0359-6.</mixed-citation><mixed-citation xml:lang="en">Yin Y., Zhang L., Xiao H., et al. The pre-amputation pain and the postoperative deafferentation are the risk factors of phantom limb pain: a clinical survey in a sample of Chinese population. BMC Anesthesiol. 2017; 17 (1): 69. https://doi.org/10.1186/s12871-017-0359-6.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Eidmann A., Kamawal Y., Luedemann M., et al. Demographics and etiology for lower extremity amputations – experiences of an university orthopaedic center in Germany. Medicina. 2023; 59 (2): 200. https://doi.org/10.3390/medicina59020200.</mixed-citation><mixed-citation xml:lang="en">Eidmann A., Kamawal Y., Luedemann M., et al. Demographics and etiology for lower extremity amputations – experiences of an university orthopaedic center in Germany. Medicina. 2023; 59 (2): 200. https://doi.org/10.3390/medicina59020200.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Rivera J.A., Churovich K., Anderson A.B., Potter B.K. Estimating recent US limb loss prevalence and updating future projections. Arch Rehabil Res Clin Transl. 2024: 6 (4): 100376. https://doi.org/10.1016/j.arrct.2024.100376.</mixed-citation><mixed-citation xml:lang="en">Rivera J.A., Churovich K., Anderson A.B., Potter B.K. Estimating recent US limb loss prevalence and updating future projections. Arch Rehabil Res Clin Transl. 2024: 6 (4): 100376. https://doi.org/10.1016/j.arrct.2024.100376.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegler-Graham K., MacKenzie E.J., Ephraim P.L., et al. Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch Phys Med Rehabil. 2008; 89 (3): 422–9. https://doi.org/10.1016/j.apmr.2007.11.005.</mixed-citation><mixed-citation xml:lang="en">Ziegler-Graham K., MacKenzie E.J., Ephraim P.L., et al. Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch Phys Med Rehabil. 2008; 89 (3): 422–9. https://doi.org/10.1016/j.apmr.2007.11.005.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Bernatchez J., Mayo A., Kayssi A. The epidemiology of lower extremity amputations, strategies for amputation prevention, and the importance of patient-centered care. Semin Vasc Surg. 2021; 34 (1): 54–8. https://doi.org/10.1053/j.semvascsurg.2021.02.011.</mixed-citation><mixed-citation xml:lang="en">Bernatchez J., Mayo A., Kayssi A. The epidemiology of lower extremity amputations, strategies for amputation prevention, and the importance of patient-centered care. Semin Vasc Surg. 2021; 34 (1): 54–8. https://doi.org/10.1053/j.semvascsurg.2021.02.011.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan B., Hu D., Gu S., et al. The global burden of traumatic amputation in 204 countries and territories. Front Public Health. 2023; 11: 1258853. https://doi.org/10.3389/fpubh.2023.1258853.</mixed-citation><mixed-citation xml:lang="en">Yuan B., Hu D., Gu S., et al. The global burden of traumatic amputation in 204 countries and territories. Front Public Health. 2023; 11: 1258853. https://doi.org/10.3389/fpubh.2023.1258853.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar A., Soliman N., Gan Z., et al. A systematic review of the prevalence of postamputation and chronic neuropathic pain associated with combat injury in military personnel. Pain. 2024; 165 (4): 727–40. https://doi.org/10.1097/j.pain.0000000000003094.</mixed-citation><mixed-citation xml:lang="en">50 Kumar A., Soliman N., Gan Z., et al. A systematic review of the prevalence of postamputation and chronic neuropathic pain associated with combat injury in military personnel. Pain. 2024; 165 (4): 727–40. https://doi.org/10.1097/j.pain.0000000000003094.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Цема Е.В., Беспаленко А.А., Динец А.В. и др. Изучение поражающих факторов современной войны, приводящих к потере конечности. Новости хирургии. 2018; 25 (3): 321–31.</mixed-citation><mixed-citation xml:lang="en">Tsema Ie.V., Bespalenko A.A., Dinets A.V., et al. Study of damaging factors of contemporary war, leading to the limb loss. Novosti khirurgii. 2018; 26 (3): 321–31 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Griffin S.C., Alphonso A.L., Tung M., et al. Characteristics of phantom limb pain in U.S. civilians and service members. Scand J Pain. 2022; 22 (1): 125–32. https://doi.org/10.1515/sjpain-2021-0139.</mixed-citation><mixed-citation xml:lang="en">Griffin S.C., Alphonso A.L., Tung M., et al. Characteristics of phantom limb pain in U.S. civilians and service members. Scand J Pain. 2022; 22 (1): 125–32. https://doi.org/10.1515/sjpain-2021-0139.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Perry B.N., Moran C.W., Armiger R.S., et al. Initial clinical evaluation of the modular prosthetic limb. Front Neurol. 2018; 9: 153. https://doi.org/10.3389/fneur.2018.00153.</mixed-citation><mixed-citation xml:lang="en">Perry B.N., Moran C.W., Armiger R.S., et al. Initial clinical evaluation of the modular prosthetic limb. Front Neurol. 2018; 9: 153. https://doi.org/10.3389/fneur.2018.00153.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Hirsh A.T., Dillworth T.M., Ehde D.M., Jensen M.P. Sex differences in pain and psychological functioning in persons with limb loss. J Pain. 2010; 11 (1): 79–86. https://doi.org/10.1016/j.jpain.2009.06.004.</mixed-citation><mixed-citation xml:lang="en">Hirsh A.T., Dillworth T.M., Ehde D.M., Jensen M.P. Sex differences in pain and psychological functioning in persons with limb loss. J Pain. 2010; 11 (1): 79–86. https://doi.org/10.1016/j.jpain.2009.06.004.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Ishigami S., Boctor C. Epidemiology and risk factors for phantom limb pain. Front Pain Res. 2024; 5: 1425544. https://doi.org/10.3389/fpain.2024.1425544.</mixed-citation><mixed-citation xml:lang="en">Ishigami S., Boctor C. Epidemiology and risk factors for phantom limb pain. Front Pain Res. 2024; 5: 1425544. https://doi.org/10.3389/fpain.2024.1425544.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Eckhoff M.D., Craft M.R., Nicholson T.C., et al. Lower extremity combat sustained peripheral nerve injury in US military personnel. Plast Reconstr Surg Glob Open. 2021; 9 (3): e3447. https://doi.org/10.1097/GOX.0000000000003447.</mixed-citation><mixed-citation xml:lang="en">Eckhoff M.D., Craft M.R., Nicholson T.C., et al. Lower extremity combat sustained peripheral nerve injury in US military personnel. Plast Reconstr Surg Glob Open. 2021; 9 (3): e3447. https://doi.org/10.1097/GOX.0000000000003447.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Mercer S., Chavan S., Tong J.L., et al. The early detection and management of neuropathic pain following combat injury. J R Army Med Corps. 2009; 155 (2): 94–8. https://doi.org/10.1136/jramc-155-02-03.</mixed-citation><mixed-citation xml:lang="en">Mercer S., Chavan S., Tong J.L., et al. The early detection and management of neuropathic pain following combat injury. J R Army Med Corps. 2009; 155 (2): 94–8. https://doi.org/10.1136/jramc-155-02-03.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Livingston K.E. The phantom limb syndrome. A discussion of the role of major peripheral nerve neuromas. J Neurosurg. 1945; 2 (3): 251–5. https://doi.org/10.3171/jns.1945.2.3.0251.</mixed-citation><mixed-citation xml:lang="en">Livingston K.E. The phantom limb syndrome. A discussion of the role of major peripheral nerve neuromas. J Neurosurg. 1945; 2 (3): 251–5. https://doi.org/10.3171/jns.1945.2.3.0251.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Issa C.J., Svientek S.R., Dehdashtian A., et al. Pathophysiological and neuroplastic changes in postamputation and neuropathic pain: review of the literature. Plast Reconstr Surg Glob Open. 2022; 10 (9): e4549. https://doi.org/10.1097/GOX.0000000000004549.</mixed-citation><mixed-citation xml:lang="en">Issa C.J., Svientek S.R., Dehdashtian A., et al. Pathophysiological and neuroplastic changes in postamputation and neuropathic pain: review of the literature. Plast Reconstr Surg Glob Open. 2022; 10 (9): e4549. https://doi.org/10.1097/GOX.0000000000004549.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">De Lange J.W.D., Hundepool C.A., Power D.M., et al. Prevention is better than cure: surgical methods for neuropathic pain prevention following amputation – a systematic review. J Plast Reconstr Aesthet Surg. 2022; 75 (3): 948–59. https://doi.org/10.1016/j.bjps.2021.11.076.</mixed-citation><mixed-citation xml:lang="en">De Lange J.W.D., Hundepool C.A., Power D.M., et al. Prevention is better than cure: surgical methods for neuropathic pain prevention following amputation – a systematic review. J Plast Reconstr Aesthet Surg. 2022; 75 (3): 948–59. https://doi.org/10.1016/j.bjps.2021.11.076.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Baron R. Mechanisms of disease: neuropathic pain – a clinical perspective. Nat Rev Neurol. 2006; 2 (2): 95–106. https://doi.org/10.1038/ncpneuro0113.</mixed-citation><mixed-citation xml:lang="en">Baron R. Mechanisms of disease: neuropathic pain – a clinical perspective. Nat Rev Neurol. 2006; 2 (2): 95–106. https://doi.org/10.1038/ncpneuro0113.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Subedi B., Grossberg G.T. Phantom limb pain: mechanisms and treatment approaches. Pain Res Treat. 2011; 2011: 864605. https://doi.org/10.1155/2011/864605.</mixed-citation><mixed-citation xml:lang="en">Subedi B., Grossberg G.T. Phantom limb pain: mechanisms and treatment approaches. Pain Res Treat. 2011; 2011: 864605. https://doi.org/10.1155/2011/864605.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Flor H., Nikolajsen L., Staehelin Jensen T. Phantom limb pain: a case of maladaptive CNS plasticity? Nat Rev Neurosci. 2006; 7 (11): 873–81. https://doi.org/10.1038/nrn1991.</mixed-citation><mixed-citation xml:lang="en">Flor H., Nikolajsen L., Staehelin Jensen T. Phantom limb pain: a case of maladaptive CNS plasticity? Nat Rev Neurosci. 2006; 7 (11): 873–81. https://doi.org/10.1038/nrn1991.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Yanagisawa T., Fukuma R., Seymour B., et al. Induced sensorimotor brain plasticity controls pain in phantom limb patients. Nat Commun. 2016; 7 (1): 13209. https://doi.org/10.1038/ncomms13209.</mixed-citation><mixed-citation xml:lang="en">Yanagisawa T., Fukuma R., Seymour B., et al. Induced sensorimotor brain plasticity controls pain in phantom limb patients. Nat Commun. 2016; 7 (1): 13209. https://doi.org/10.1038/ncomms13209.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Решетняк В.К., Кукушкин М.Л., Гурко Н.С. Патогенетические механизмы фантомно-болевого синдрома. Патологическая физиология и экспериментальная терапия. 2015; 59 (4): 101–7.</mixed-citation><mixed-citation xml:lang="en">Reshetnyak V.K., Kukushkin M.L., Gurko N.C. Pathogenetic mechanisms of phantom-pain syndrome. Patologicheskaya fiziologiya i eksperimental’naya terapiya / Pathological physiology and experimental therapy. 2015; 59 (4): 101–7 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Makin T.R. Phantom limb pain: thinking outside the (mirror) box. Brain. 2021; 144 (7): 1929–32. https://doi.org/10.1093/brain/awab139.</mixed-citation><mixed-citation xml:lang="en">Makin T.R. Phantom limb pain: thinking outside the (mirror) box. Brain. 2021; 144 (7): 1929–32. https://doi.org/10.1093/brain/awab139.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Katz J., Melzack R. Pain ‘memories’ in phantom limbs: review and clinical observations. Pain. 1990; 43 (3): 319–36. https://doi.org/10.1016/0304-3959(90)90029-d.</mixed-citation><mixed-citation xml:lang="en">Katz J., Melzack R. Pain ‘memories’ in phantom limbs: review and clinical observations. Pain. 1990; 43 (3): 319–36. https://doi.org/10.1016/0304-3959(90)90029-d.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Ramachandran V.S., Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc Biol Sci. 1996; 263 (1369): 377–86. https://doi.org/10.1098/rspb.1996.0058.</mixed-citation><mixed-citation xml:lang="en">Ramachandran V.S., Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc Biol Sci. 1996; 263 (1369): 377–86. https://doi.org/10.1098/rspb.1996.0058.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Makin T.R., Flor H. Brain (re)organisation following amputation: implications for phantom limb pain. Neuroimage. 2020; 218: 116943. https://doi.org/10.1016/j.neuroimage.2020.116943.</mixed-citation><mixed-citation xml:lang="en">Makin T.R., Flor H. Brain (re)organisation following amputation: implications for phantom limb pain. Neuroimage. 2020; 218: 116943. https://doi.org/10.1016/j.neuroimage.2020.116943.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Andoh J., Milde C., Diers M., et al. Assessment of cortical reorganization and preserved function in phantom limb pain: a methodological perspective. Sci Rep. 2020; 10 (1): 11504. https://doi.org/10.1038/s41598-020-68206-9.</mixed-citation><mixed-citation xml:lang="en">Andoh J., Milde C., Diers M., et al. Assessment of cortical reorganization and preserved function in phantom limb pain: a methodological perspective. Sci Rep. 2020; 10 (1): 11504. https://doi.org/10.1038/s41598-020-68206-9.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Melzack R. Phantom limbs and the concept of a neuromatrix. Trends Neurosci. 1990; 13 (3): 88–92. https://doi.org/10.1016/0166-2236(90)90179-e.</mixed-citation><mixed-citation xml:lang="en">Melzack R. Phantom limbs and the concept of a neuromatrix. Trends Neurosci. 1990; 13 (3): 88–92. https://doi.org/10.1016/0166-2236(90)90179-e.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Melzack R. Pain and the neuromatrix in the brain. J Dent Educ. 2001; 65 (12): 1378–82.</mixed-citation><mixed-citation xml:lang="en">Melzack R. Pain and the neuromatrix in the brain. J Dent Educ. 2001; 65 (12): 1378–82.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Collins K.L., Russell H.G., Schumacher P.J., et al. A review of current theories and treatments for phantom limb pain. J Clin Invest. 2018; 128 (6): 2168–76. https://doi.org/10.1172/JCI94003.</mixed-citation><mixed-citation xml:lang="en">Collins K.L., Russell H.G., Schumacher P.J., et al. A review of current theories and treatments for phantom limb pain. J Clin Invest. 2018; 128 (6): 2168–76. https://doi.org/10.1172/JCI94003.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson-Barnes V.C., McAuliffe C., Swanberg K.M., Tsao J.W. Phantom limb pain – a phenomenon of proprioceptive memory? Med Hypotheses. 2009; 73 (4): 555–8. https://doi.org/10.1016/j.mehy.2009.05.038.</mixed-citation><mixed-citation xml:lang="en">Anderson-Barnes V.C., McAuliffe C., Swanberg K.M., Tsao J.W. Phantom limb pain – a phenomenon of proprioceptive memory? Med Hypotheses. 2009; 73 (4): 555–8. https://doi.org/10.1016/j.mehy.2009.05.038.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Ergenzinger E.R., Glasier M.M., Hahm J.O., Pons T.P. Cortically induced thalamic plasticity in the primate somatosensory system. Nat Neurosci. 1998; 1 (3): 226–9. https://doi.org/10.1038/673.</mixed-citation><mixed-citation xml:lang="en">Ergenzinger E.R., Glasier M.M., Hahm J.O., Pons T.P. Cortically induced thalamic plasticity in the primate somatosensory system. Nat Neurosci. 1998; 1 (3): 226–9. https://doi.org/10.1038/673.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Davis K.D., Kiss Z.H., Luo L., et al. Phantom sensations generated by thalamic microstimulation. Nature. 1998; 391 (6665): 385–7. https://doi.org/10.1038/34905.</mixed-citation><mixed-citation xml:lang="en">Davis K.D., Kiss Z.H., Luo L., et al. Phantom sensations generated by thalamic microstimulation. Nature. 1998; 391 (6665): 385–7. https://doi.org/10.1038/34905.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Waxman S.G., Hains B.C. Fire and phantoms after spinal cord injury: Na+ channels and central pain. Trends Neurosci. 2006; 29 (4): 207–15. https://doi.org/10.1016/j.tins.2006.02.003.</mixed-citation><mixed-citation xml:lang="en">Waxman S.G., Hains B.C. Fire and phantoms after spinal cord injury: Na+ channels and central pain. Trends Neurosci. 2006; 29 (4): 207–15. https://doi.org/10.1016/j.tins.2006.02.003.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Li C.X., Chappell T.D., Ramshur J.T., Waters R.S. Forelimb amputation-induced reorganization in the ventral posterior lateral nucleus (VPL) provides a substrate for large-scale cortical reorganization in rat forepaw barrel subfield (FBS). Brain Res. 2014; 1583: 89–108. https://doi.org/10.1016/j.brainres.2014.07.022.</mixed-citation><mixed-citation xml:lang="en">Li C.X., Chappell T.D., Ramshur J.T., Waters R.S. Forelimb amputation-induced reorganization in the ventral posterior lateral nucleus (VPL) provides a substrate for large-scale cortical reorganization in rat forepaw barrel subfield (FBS). Brain Res. 2014; 1583: 89–108. https://doi.org/10.1016/j.brainres.2014.07.022.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Davidson J.H., Khor K.E., Jones L.E. A cross-sectional study of post-amputation pain in upper and lower limb amputees, experience of a tertiary referral amputee clinic. Disabil Rehabil. 2010; 32 (22): 1855–62. https://doi.org/10.3109/09638281003734441.</mixed-citation><mixed-citation xml:lang="en">Davidson J.H., Khor K.E., Jones L.E. A cross-sectional study of post-amputation pain in upper and lower limb amputees, experience of a tertiary referral amputee clinic. Disabil Rehabil. 2010; 32 (22): 1855–62. https://doi.org/10.3109/09638281003734441.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Ткаченко Г.А., Степанова А.М., Мерзлякова А.М. Психологическая коррекция фантомной боли у онкологических больных. Саркомы костей, мягких тканей и опухоли кожи. 2017; 3: 38–42.</mixed-citation><mixed-citation xml:lang="en">Tkachenko G.A., Stepanova A.M., Merzlyakova A.M. Psychological correction of phantom pain in cancer patients. Bone and Soft Tissue Sarcomas, Tumors of the Skin. 2017; 3: 38–42 (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Bates T.J., Fergason J.R., Pierrie S.N. Technological advances in prosthesis design and rehabilitation following upper extremity limb loss. Curr Rev Musculoskelet Med. 2020; 13 (4): 485–93. https://doi.org/10.1007/s12178-020-09656-6.</mixed-citation><mixed-citation xml:lang="en">Bates T.J., Fergason J.R., Pierrie S.N. Technological advances in prosthesis design and rehabilitation following upper extremity limb loss. Curr Rev Musculoskelet Med. 2020; 13 (4): 485–93. https://doi.org/10.1007/s12178-020-09656-6.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
