References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2025.211

epilepsia-1189

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Рart II: Overcoming strategies

Гипотезы развития и стратегии преодоления фармакорезистентности при эпилепсии. Часть II: Стратегии преодоления

https://orcid.org/0009-0006-0479-126X

Якимов

А. М.

Yakimov

A. M.

Якимов Алексей Михайлович

WoS ResearcherID: AEW-9605- 2022. Scopus Author ID: 58161933100

ул. Партизана Железняка, д. 1, Красноярск 660022

Alexey M. Yakimov

WoS ResearcherID: AEW-9605- 2022. Scopus Author ID: 58161933100

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0000-0002-4555-7457

Тимечко

Е. Е.

Timechko

E. E.

Тимечко Елена Евгеньевна

WoS ResearcherID: CAF-2677- 2022

ул. Партизана Железняка, д. 1, Красноярск 660022

Elena E. Timechko

WoS ResearcherID: CAF-2677- 2022

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0000-0002-9394-2413

Парамонова

А. И.

Paramonova

A. I.

Парамонова Анастасия Ивановна

WoS ResearcherID: HMP-3496-2023

ул. Партизана Железняка, д. 1, Красноярск 660022

Anastasia I. Paramonova

WoS ResearcherID: HMP-3496-2023

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0009-0008-3369-1537

Васильева

А. А.

Vasilieva

A. A.

Васильева Анастасия Александровна

ул. Партизана Железняка, д. 1, Красноярск 660022

Anastasia A. Vasilieva

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0009-0006-4391-2669

Рыбаченко

Ф. К.

Rybachenko

F. K.

Рыбаченко Фёдор Константинович

ул. Партизана Железняка, д. 1, Красноярск 660022

Fedor K. Rybachenko

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0009-0004-1108-6249

Рыбаченко

А. Д.

Rybachenko

A. D.

Рыбаченко Анастасия Дмитриевна

ул. Партизана Железняка, д. 1, Красноярск 660022

Anastasia D. Rybachenko

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0000-0003-4639-6365

Дмитренко

Д. В.

Dmitrenko

D. V.

Дмитренко Диана Викторовна, д.м.н.

WoS ResearcherID: H-7787-2016

ул. Партизана Железняка, д. 1, Красноярск 660022

Diana V. Dmitrenko, Dr. Sci. Med.

WoS ResearcherID: H-7787-2016

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

mart2802@yandex.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияVoino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation

2025

02052025

1715970

2025

Якимов А.М., Тимечко Е.Е., Парамонова А.И., Васильева А.А., Рыбаченко Ф.К., Рыбаченко А.Д., Дмитренко Д.В.

Yakimov A.M., Timechko E.E., Paramonova A.I., Vasilieva A.A., Rybachenko F.K., Rybachenko A.D., Dmitrenko D.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/1189

To date, despite the complexity and risks of not removing seizures hippocampal resection is the only effective solution to overcome drug resistance in epilepsy. Recently, a significant amount of data has been accumulated on the mechanisms of drug resistance development, which allows to develop innovative strategies to overcome it. New antiepileptic drugs have been emerging, directly aimed at acting on disease etiological substrate (many of them are at the stage of clinical trials). Targeted therapy have been extensively introduced, and coupled with precision medicine methods can potentially aid in finding a personalized approach to each individual patient. Migraine models also achieve a qualitatively new level, providing researchers an opportunity to develop highly effective systems for identifying previously unknown disease components, as well as assessing an effect of new drugs. The aim of this review was to highlight current approaches to the treatment of epilepsy and overcoming drug resistance.

На сегодняшний день единственным эффективным решением проблемы фармакорезистентности при эпилепсии, несмотря на сложность и риски отсутствия освобождения от приступов, является хирургическое лечение. За последнее время накоплен значительный массив данных о механизмах формирования фармакорезистентности, что позволяет разрабатывать инновационные стратегии ее преодоления. Появляются новые противоэпилептические препараты, активность которых направлена на непосредственную этиологию заболевания (многие из них находятся на стадии клинических испытаний). Интенсивно внедряются методы таргетной терапии, что в сочетании с инструментами прецизионной медицины потенциально позволит находить персонализованный подход к каждому отдельному пациенту. Создание моделей также выходит на качественно новый уровень, предоставляя исследователям возможность разработки высокоэффективных систем идентификации ранее неизвестных компонентов заболевания, оценки действия новых лекарственных средств. Целью настоящей статьи стало изучение существующих инновационных стратегий терапии эпилепсии и преодоления фармакорезистентности.

фармакорезистентная эпилепсиястратегии преодоления фармакорезистентностигенная терапияпрецизионная медицинапротивоэпилептические препараты

drug-resistant epilepsystrategies to overcome drug resistancegene therapyprecision medicineantiepileptic drugs

Обзор подготовлен в рамках госзадания «Идентификация предикторов фармакорезистентного течения и исходов хирургического лечения эпилепсии» (No 1023022100003-4)

The review was conducted within the framework of the state task "Identification of predictors for pharmacoresistant course and outcomes of surgical treatment of epilepsy" (No. 1023022100003-4)

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The authors declare that there are no conflicts of interest present.