References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2025.231

epilepsia-1239

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Bioelectronic medicine: a new frontier for autonomic nervous system disorders

Биоэлектронная медицина: новый рубеж в лечении заболеваний вегетативной нервной системы

https://orcid.org/0000-0001-7655-1667

Дхалл

М.

Dhall

Маниш Дхалл, магистр фармацевтики, доктор философии

Дарьяо Нагар, Рохтак, Харьяна 124001

Manish Dhall, M. Pharm., PhD

https://orcid.org/0009-0007-4117-2940

Тушир

Р.

Tushir

Рену Тушир, магистр фармацевтики

Сохна, Гуруграм, Харьяна 122103

Renu Tushir, M. Pharm.

renutushir8@gmail.com

https://orcid.org/0000-0002-9539-3139

Шарма

П.

Sharma

Прерна Шарма, доцент

XV69+CQH, Амри-роуд, сектор 8, Курукшетра, Харьяна 136118

Prerna Sharma, Assoc. Prof.

https://orcid.org/0000-0003-2549-3481

Рани

Н.

Rani

Нидхи Рани, магистр фармацевтики, доктор философии, доцент

Пенджаб 140401

Nidhi Rani, M. Pharm., PhD, Assoc. Prof

https://orcid.org/0000-0003-2979-1590

Сингх

Т. Г.

Singh

Тхакур Гуржит Сингх, проф.

WoS ResearcherID: AGV-7671-2022

Scopus Author ID: 27667828700

Пенджаб 140401

Thakur Gurjeet Singh, Prof.

Университет медицинских наук Пандита Бхагвата Даяла ШармыИндияCollege of Pharmacy, PGIMS (SDPGIPS) Pandit Bhagwat Dayal Sharma University of Health Sciences ROHTAK-124001India

Университет Г.Д. ГоенкаИндияGD Goneka UniversityIndia

Университет Шри Кришны АЮШИндияShri Kirishna AYUSH UniversityIndia

Университет ЧиткараИндияChitkara College of Pharmacy, Сhitkara UniversityIndia

2025

14102025

173297307

2025

Дхалл М., Тушир Р., Шарма П., Рани Н., Сингх Т.Г.

Dhall M., Tushir R., Sharma P., Rani N., Singh T.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/1239

Bioelectronic medicine is a field of study that is constantly evolving as a result of recent advancements and improvements in bioelectronic technology, which have led to novel approaches and perspectives in disease diagnosis and therapy, particularly in the inflammatory reflex immuno-regulatory functioning and, vagus nerve stimulation (VNS). The vagus nerve, an elongated nerve in the autonomic nervous system, controls a number of physiological processes in humans, including blood pressure, breathing rate, vasomotor activity, and certain reflex movements. Recent bioelectronic research has led to clinical tests using VNS for inflammatory diseases and other conditions. By sending steady, gentle electric impulses through the vagus nerve to the brain, bioelectronic devices can activate the vagus nerve. The integration of artificial intelligence (AI) with bioelectronic medicine is transforming drug development processes. AI technology can accelerate or even eliminate many time-consuming tasks, allowing healthcare professionals to use their time more efficiently and ultimately improving healthcare outcomes. This review discusses the vagus nerve’s roles in inflammation, stimulation, and regulation in animal models, as well as its therapeutic potential in treating human inflammation. Additionally, it examines how AI-powered bioelectronic drugs are being explored for conditions such as paralysis and immune disorders, and addresses the challenges of delivering large molecules using these drugs. The article emphasizes current trends, advancements, and the promising future applications of combining AI with bioelectronic medicine.

Биоэлектронная медицина – это область исследований, которая постоянно развивается благодаря последним достижениям и совершенствованию биоэлектронных технологий, которые привели к появлению новых подходов и перспектив в диагностике и терапии заболеваний, в частности в области воспалительных рефлекторных иммунорегуляторных функций и стимуляции блуждающего нерва (англ. vagus nerve stimulation, VNS). Блуждающий нерв, протяженный нерв вегетативной нервной системы, контролирует ряд физиологических процессов в организме человека, включая артериальное давление, частоту дыхания, вазомоторную активность и некоторые рефлекторные движения. Недавние исследования в сфере биоэлектроники позволили проводить клинические тесты с использованием технологии VNS при воспалительных заболеваниях и других состояниях. Посылая непрерывные слабые электрические импульсы через блуждающий нерв в мозг, биоэлектронные устройства могут активировать блуждающий нерв. Интеграция искусственного интеллекта (ИИ) с биоэлектронной медициной преобразует процессы разработки лекарственных препаратов. Технологии ИИ могут ускорить или даже исключить выполнение различных трудоемких задач, позволяя медицинским работникам более эффективно использовать свое время и, в конечном итоге, улучшать результаты лечения. В настоящем обзоре рассмотрена роль блуждающего нерва в воспалении, стимуляции и регуляции в животных моделях, его терапевтический потенциал в лечении воспаления у человека. Кроме того, освещены вопросы проведения исследований по оценке биоэлектронных препаратов на основе ИИ для терапии таких состояний, как паралич и иммунные расстройства, а также доставки крупных молекул с помощью указанных препаратов. Проанализированы текущие тенденции, достижения и перспективные подходы к применению ИИ в биоэлектронной медицине.

иммунорегуляторные механизмырефлекторная активностьбиоэлектронные препаратыревматоидный артритискусственный интеллектстимуляция блуждающего нерва

immuno-regulatory mechanismsreflex activitiesbioelectronic medicinesrheumatoid arthritisartificial intelligencevagus nerve stimulation

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The authors declare that there are no conflicts of interest present.