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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">epilepsia-168</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group></article-categories><title-group><article-title>TICS IN CHILDREN. CLINICAL RESULT OF THE TREATMENT TIC DISORDERS BY LEVETIRACETAM</article-title><trans-title-group xml:lang="ru"><trans-title>ТИКИ У ДЕТЕЙ. КЛИНИЧЕСКИЙ ПРИМЕР ЛЕЧЕНИЯ ТИКОВ ПРЕПАРАТОМ ЛЕВЕТИРАЦЕТАМ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бородина</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Borodina</surname><given-names>Ju. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бородина Юлия Вячеславовна – кандидат медицинских наук, врач-невролог, больница Научного центра РАН в Черноголовке.</p><p>Адрес: Лесная, 6, г. Черноголовка, Московская обл., 142432</p></bio><bio xml:lang="en"><p>Borodina Ju.V. – MD, neurologist, hospital Scientific Center RAS in Chernogolovka.</p><p>Address: Chernogolovka, Lesnaya, 6,MoscowRegion, 142432,Russia. </p></bio><email xlink:type="simple">julbor2010@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрьева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Jur’eva</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юрьева Наталья Вячеславовна – кандидат медицинских наук, врач-невролог СОКБ.</p><p>Адрес: пр. Гагарина, 27, Смоленск, 214018</p></bio><bio xml:lang="en"><p>Jur’eva N.V. – MD, neurologist, Smolensk regional clinical hospital.</p><p>Address: Gagarin ave., 27, Smolensk, 214018, Russia.</p></bio><email xlink:type="simple">yustra@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маслова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Maslova</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маслова Наталья Николаевна – доктор медицинских наук, профессор, заведующая кафедрой неврологии и нейрохирургии.</p><p>Адрес: ул. Крупской, 28, Смоленск, 214019.</p></bio><bio xml:lang="en"><p>Maslova N.N. – MD, Professor, Head of the Department of Neurology and Neurosurgery.</p><p>Address: Krupskaya str., 28, Smolensk, 214019, Russia. </p></bio><email xlink:type="simple">maslovasm@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Смоленский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Smolensk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>11</day><month>06</month><year>2016</year></pub-date><volume>7</volume><issue>1</issue><fpage>41</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Borodina J.V., Jur’eva N.V., Maslova N.N., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Бородина Ю.В., Юрьева Н.В., Маслова Н.Н.</copyright-holder><copyright-holder xml:lang="en">Borodina J.V., Jur’eva N.V., Maslova N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/168">https://www.epilepsia.su/jour/article/view/168</self-uri><abstract><p>Tics are one of the most common neuropsychiatric disorders in children. Major role in the etiology of the disease plays a lack of work dopaminergic system, which leads to impaired attention, self-control and behavioral inhibition, reduced control of motor activity and the appearance of excessive, uncontrolled movements. Under the influence of levetiracetam, probably there is a change of neurotransmitter systems with stimulation of inhibitory mechanisms, which leads to rapid clinical and neurophysiological effects.</p></abstract><trans-abstract xml:lang="ru"><p>Тикозные расстройства являются одним из самых частых психоневрологических расстройств детского возраста. Основную роль в этиологии заболевания играет недостаточность работы дофаминергической системы, что приводит к нарушениям внимания, саморегуляции и поведенческого торможения, снижению контроля двигательной активности и появлению избыточных, неконтролируемых движений. Под воздействием леветирацетама, вероятно, происходит изменение нейромедиаторных систем со стимуляцией тормозных механизмов, что ведет к быстрому клиническому и нейрофизиологическому эффектам.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тики</kwd><kwd>ЭЭГ</kwd><kwd>ЭНМГ</kwd><kwd>леветирацетам.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>TIC disorders</kwd><kwd>EEG</kwd><kwd>ENMG</kwd><kwd>levetiracetam</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Делягин В.М. Тики у детей. Русский медицинский журнал. 2013; 36: 8-14.</mixed-citation><mixed-citation xml:lang="en">Delyagin V.M. Tiki u detei. Russkii meditsinskii zhurnal. 2013; 36: 8-14.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ермоленко Н.А., Ермаков А.Ю., К.В. Воронкова К.В, Захарова Е.И. 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