epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLCepilepsia-177Research ArticleSCIENTIFIC SURVEYSНАУЧНЫЕ ОБЗОРЫMIGRAINE AND EPILEPSYМИГРЕНЬ И ЭПИЛЕПСИЯАзимоваЮ. Э.AzimovaYu. E.

Отдел неврологии и клинической нейрофизиологии

Department of Neurology and Clinical Neurophysiology

ТабееваГ. Р.TabeevaG. R.

Отдел неврологии и клинической нейрофизиологии

Department of Neurology and Clinical Neurophysiology

ММА им. И.М. СеченоваРоссияI. M. Sechenov Moscow Medical AcademyRussian Federation200921082016112125Copyright © Azimova Y.E., Tabeeva G.R., 20162016Азимова Ю.Э., Табеева Г.Р.Azimova Y.E., Tabeeva G.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/177

Migraine and epilepsy are comorbid neurological diseases that have common clinical and pathophysiological features, as well as common approaches to their treatment. Existing epilepsy increases the risk of development of migraine by 2.4-fold, while migraine makes development of epilepsy 4.1 times more likely. A combination of migraine and epilepsy aggravates the progression of each of these diseases. The most probable cause of the comorbidity of migraine and epilepsy is the common pathophysiological alterations that result in excessive excitation of neurons in the central nervous system, whereas anticonvulsants, which are effective in the treatment of either of these diseases, decrease neuronal excitation. Understanding of the common pathophysiological mechanisms of migraine and epilepsy broadens the current conception of the mechanisms underlying the symptoms of both diseases and offers a new perspective in their treatment

Мигрень и эпилепсия – коморбидные невроло- гические заболевания, имеющие общие клинические и патофизиологические черты, а также общие подходы к терапии. Эпилепсия повышает риск развития мигрени в 2,4 раза, а мигрень повышает риск развития эпилепсии в 4,1 раз. Сочетание мигрени и эпилепсии утя- желяет течение обоих заболеваний. Наиболее вероятной причиной коморбидности мигрени и эпилепсии являются общие патофизиологические изменения, приводящие к гиперврозбудимости нейронов центральной нервной системы, тогда как антиконвульсанты, эффективные для лечения обоих заболеваний, снижают возбудимость нейронов. Понимание общих патофизиологических механизмов мигрени и эпилепсии расширяют наши представления о механизмах симптомообразования обоих заболеваний и открывают новые перспективы их лечения.

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The authors declare that there are no conflicts of interest present.