epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLCepilepsia-180Research ArticleSCIENTIFIC SURVEYSНАУЧНЫЕ ОБЗОРЫTOPIRAMATE APPLICATION IN COMPLEX TREATMENT OF EPILEPSYПРИМЕНЕНИЕ ПРЕПАРАТА ТОПИРАМАТ В КОМПЛЕКСНОЙ ТЕРАПИИ ЭПИЛЕПСИИБадалянО. Л.BadalyanO. L.СавенковА. А.SavenkovA. A.ТаишеваК. Х.TaishevaK. H.ТертышникО. Ю.TertyshnikO. Yu.ГОУ ВПО «Российский государственный медицинский университет им. Н.И. Пирогова» РосздраваРоссияGOU VPO Russian State Medical University named after N.I. PirogovRussian Federation201022082016212529Copyright © Badalyan O.L., Savenkov A.A., Taisheva K.H., Tertyshnik O.Y., 20162016Бадалян О.Л., Савенков А.А., Таишева К.Х., Тертышник О.Ю.Badalyan O.L., Savenkov A.A., Taisheva K.H., Tertyshnik O.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/180

Topiramate (Topamax®) is one of the most widely used modern anti-epileptic drugs (AED) in Russia. This is primarily due to the broad spectrum of activity of this drug. Its mechanism of action is complex and includes several components. It was shown that all main mechanisms of epilepsy development are within the pharmacological targets of this drug, which makes it distinguished among other AED. The drug is efficient in both focal and generalized forms of epilepsy. The following adverse effects of treatment may possibly develop: fatigability, thought disorder, headache and confused mental state. It should be borne in mind that the majority of adverse effects disappeared spontaneously in the course of treatment. Such adverse effects as reduction of body weight and nephrolithiasis generally occurred as long-term side effects of treatment.

В России одним из наиболее широко применямых новых ПЭП является топирамат (Топамакс®). Это обусловлено, в первую очередь, широтой спектра действия данного пре- парата. Механизм действия имеет сложный характер и включает несколько составляющих. Показано, что в основе фармакологических эффектов данного препарата лежит воздействие на все основные механизмы раз- вития эпилептического процесса, что принципиально выделяет его среди других ПЭП. Препарат эффективен как при фокальных, так и при генерализованных формах эпилепсии. Из побочных эффектов возможны утомляемость, затруднения мышления, головная боль и спутанность сознания. Следует иметь в виду, что большинство побочных явлений спонтанно проходили по мере продолжения терапии. Из побочных эффектов, возникающих на отдаленных этапах терапии, следует назвать снижение веса тела, нефролитиаз.

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The authors declare that there are no conflicts of interest present.