epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLCepilepsia-188Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИDYSEMBRYOGENETIC STIGMATA AND PHYSICAL DEVELOPMENT IN CHILDREN BORN TO EPILEPTIC MOTHERSСТИГМЫ ДИЗЭМБРИОГЕНЕЗА И ФИЗИЧЕСКОЕ РАЗВИТИЕ У ДЕТЕЙ, РОЖДЕННЫХ ОТ МАТЕРЕЙ, СТРАДАЮЩИХ ЭПИЛЕПСИЕЙКожокаруА. Б.KozhokaruA. B.

кафедра нервных болезней

Department of Neurology

КарловВ. А.KarlovV. A.

кафедра нервных болезней

Department of Neurology

ЖидковаИ. А.ZhidkovaI. A.

кафедра нервных болезней

Department of Neurology

СеркинаА. В.SerkinaA. V.

кафедра нервных болезней

Department of Neurology

МГМСУ, МЦ «Невромед-Клиника», МоскваРоссияMoscow State Medical and Dental University, and Medical Center «Neuromed-Clinic», MoscowRussian Federation201024082016222531Copyright © Kozhokaru A.B., Karlov V.A., Zhidkova I.A., Serkina A.V., 20162016Кожокару А.Б., Карлов В.А., Жидкова И.А., Серкина А.В.Kozhokaru A.B., Karlov V.A., Zhidkova I.A., Serkina A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/188

To investigate physical development and dysembryogenetic stigmata in children born to epileptic mothers. Materials: 50 patients (main group) are children born to epileptic mothers, and 50 children (control group) who are born to somatically healthy mothers. Study method: clinico-neurological method. Results: For the moment of investigation, no reliable, statistically significant differences in body mass, height, head or chest circumference have been found between the group of children born to epileptic mothers and group of children born to somatically healthy mothers (р > 0.05). In 20 (40%) of examined children the dysembryogenetic stigmata were found. Statistically significant changes in children born to epileptic mothers, and having dysembryogenetic stigmata, were found as compared to children born to somatically healthy mothers. Conclusions. 1) The rate of dysembryogenetic stigmata found in children born to epileptic mothers, who took anti-epileptic drugs (AED) during pregnancy, exceeds by approximately 10-fold the population indices. 2) Physical development of children born to epileptic mothers did not differ from that of children born to somatically healthy mothers. 3) The choice of AED for treatment during pregnancy should take into account the AED relative teratogenic potential (development of congenital abnormalities and effect on further cognitive development), as well as AED efficiency against seizures during pregnancy, depending on the form of epilepsy.

Цель исследования. Изучить физическое развитие и стигмы дизэмбриогенеза у детей, рожденных от матерей, страдающих эпилепсией. Материалы: 50 пациентов (основная группа) – дети, рожденные от матерей, страдающих эпилепсией и 50 детей (контрольная группа), рожденных от соматически здоровых матерей. Методы исследования: клинко- неврологический метод. Результаты: Достоверных статистически значимых различий по массе тела, росту, окружности головы и груди на момент обследования, среди детей рожденных от матерей, страдающих эпилепсией и детей, рожденных от соматически здоровых матерей, не выявлено, р> 0,05. У 20 (40%) обследованных детей выявлялись стигмы дизэмбриогенеза. Выявлены статистически значи мые изменения, у детей, рожденных от матерей, страдающих эпилепсией, у которых отмечались стигмы дизэмбриогенеза, по сравнению с детьми, рожденными от соматически здоровых матерей. Выводы. 1) Стигмы дизэмбриогенеза, выявленные у детей, рожденных от матерей страдающих эпилепсией и принимавших АЭП во время беременности превышают популяционные показатели примерно в 10 раз. 2) Физическое развитие детей, рожденных от матерей, страдающих эпилепсией, не отличается от детей, рожденных от соматически здоровых матерей. 3) При выборе АЭП для терапии во время беременности необходимо учитывать относительный тератогенный потенциал АЭП (развитие врожденных аномалий и влияние на дальнейшее когнитивное развитие) и эффективность АЭП в отношении приступов во время беременности, в зависимости от формы эпилепсии.

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The authors declare that there are no conflicts of interest present.