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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">epilepsia-208</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>Possible pathogenetic mechanisms of failure epilepsy treatment with carbamazepine</article-title><trans-title-group xml:lang="ru"><trans-title>ВОЗМОЖНЫЕ ПАТОГЕНЕТИЧЕСКИЕ МЕХАНИЗМЫ НЕЭФФЕКТИВНОСТИ ТЕРАПИИ ЭПИЛЕПСИИ КАРБАМАЗЕПИНОМ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крикова</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krikova</surname><given-names>K. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурд</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Burd</surname><given-names>S. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НЦПЗ РАМН</institution><country>Russian Federation</country></aff><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГОУ ВПО РГМУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GOU VPO «Russian state medical university named after N.I. Pirogov» of Roszdrav</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>27</day><month>08</month><year>2016</year></pub-date><volume>3</volume><issue>1</issue><fpage>20</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Krikova K.V., Burd S.G., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Крикова К.В., Бурд С.Г.</copyright-holder><copyright-holder xml:lang="en">Krikova K.V., Burd S.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/208">https://www.epilepsia.su/jour/article/view/208</self-uri><abstract/><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>ЭПИЛЕПСИЯ</kwd><kwd>КАРБАМАЗЕПИН</kwd><kwd>ВАЛЬПРОАТЫ (ДЕПАКИН)</kwd><kwd>ГАМК</kwd></kwd-group><kwd-group xml:lang="en"><kwd>EPILEPSY</kwd><kwd>CARBAMAZEPINE</kwd><kwd>VALPROIC ACID (DEPAKINE)</kwd><kwd>GABA</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Болдырева С.Р., Ермаков А.Ю. Сравнительная эффективность карбамазепина, препаратов вальпроевой кислоты и топирамата при височной медиальной эпилепсии у детей. // Журнал Неврологии и психиатрии им. С. С. Корсакова. – 4. – 2010. – 42-47.</mixed-citation><mixed-citation xml:lang="en">Болдырева С.Р., Ермаков А.Ю. Сравнительная эффективность карбамазепина, препаратов вальпроевой кислоты и топирамата при височной медиальной эпилепсии у детей. // Журнал Неврологии и психиатрии им. С. С. Корсакова. – 4. – 2010. – 42-47.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Aronica E., Boer K., Redeker S., Spliet W. G., van Rijen P. C., Troost D., Gorter J. A. (2007), Neuroscience; 145 (1): 185–96,</mixed-citation><mixed-citation xml:lang="en">Aronica E., Boer K., Redeker S., Spliet W. G., van Rijen P. C., Troost D., Gorter J. A. (2007), Neuroscience; 145 (1): 185–96,</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Babb T. L., Brown W. J. (1987) . In: Engel J. J., editor. Surgical Treatment of the Epilepsies. N. Y.: Raven Press; pp. 511–540.,</mixed-citation><mixed-citation xml:lang="en">Babb T. L., Brown W. J. (1987) . In: Engel J. J., editor. Surgical Treatment of the Epilepsies. N. Y.: Raven Press; pp. 511–540.,</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Babb T. L., Pretorius J. K., Kupfer W. R., Crandall PH. (1989) J. Neurosci.; 9 (7): 2562–74,</mixed-citation><mixed-citation xml:lang="en">Babb T. L., Pretorius J. K., Kupfer W. R., Crandall PH. (1989) J. Neurosci.; 9 (7): 2562–74,</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Beamanoir A., Mira L. (2003) Eds. Beamanoir A., et al. Milan, Italy: John Libby Eurotext: 195-205.</mixed-citation><mixed-citation xml:lang="en">Beamanoir A., Mira L. (2003) Eds. Beamanoir A., et al. Milan, Italy: John Libby Eurotext: 195-205.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Beamanoir A, Mira L. (2003), Eds. Beamanoir A., et al. Milan, Italy: John Libby Eurotext 2003: 195-205</mixed-citation><mixed-citation xml:lang="en">Beamanoir A, Mira L. (2003), Eds. Beamanoir A., et al. Milan, Italy: John Libby Eurotext 2003: 195-205</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ben-Ari Y., Gaiarsa J. L., Tyzio R., Khazipov R. (2007), Physiol Rev. Oct; 87 (4): 1215-84</mixed-citation><mixed-citation xml:lang="en">Ben-Ari Y., Gaiarsa J. L., Tyzio R., Khazipov R. (2007), Physiol Rev. Oct; 87 (4): 1215-84</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bertelli M., Cecchin S., Lapucci C., de Gemmis P., Danieli D., d’Amore E. S., Buttolo L., Giunta F., Mortini P., Pandolfo M. (2007) . Biochim. Biophys. Acta.; 1772 (1): 15–20</mixed-citation><mixed-citation xml:lang="en">Bertelli M., Cecchin S., Lapucci C., de Gemmis P., Danieli D., d’Amore E. S., Buttolo L., Giunta F., Mortini P., Pandolfo M. (2007) . Biochim. Biophys. Acta.; 1772 (1): 15–20</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Blaesse P., Airaksinen M. S., Rivera C., Kaila K. (2009), Neuron. Mar 26; 61 (6): 820-38.</mixed-citation><mixed-citation xml:lang="en">Blaesse P., Airaksinen M. S., Rivera C., Kaila K. (2009), Neuron. Mar 26; 61 (6): 820-38.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bourgeois B. F. (1998), Brain Dev.; 20 (3): 135–41.</mixed-citation><mixed-citation xml:lang="en">Bourgeois B. F. (1998), Brain Dev.; 20 (3): 135–41.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chugani D. C., Muzik O., Juhasz C., Janisse J. J., Ager J., Chugani H. T. (2001) . Ann. Neurol.; 49 (5): 618–26</mixed-citation><mixed-citation xml:lang="en">Chugani D. C., Muzik O., Juhasz C., Janisse J. J., Ager J., Chugani H. T. (2001) . Ann. Neurol.; 49 (5): 618–26</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cobas A., Fairйn A., Alvarez-Bolado G., Sбnchez M. P. (1991), Neuroscience.; 40 (2): 375-97</mixed-citation><mixed-citation xml:lang="en">Cobas A., Fairйn A., Alvarez-Bolado G., Sбnchez M. P. (1991), Neuroscience.; 40 (2): 375-97</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen I., Navarro V., Clemenceau S., Baulac M., Miles R. (2002) Science.; 298 (5597): 1418–21.</mixed-citation><mixed-citation xml:lang="en">Cohen I., Navarro V., Clemenceau S., Baulac M., Miles R. (2002) Science.; 298 (5597): 1418–21.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Crestani F., Assandri R., Tдuber M., Martin J. R., Rudolph U., (2002), Neuropharmacology. Sep; 43 (4): 679-84.</mixed-citation><mixed-citation xml:lang="en">Crestani F., Assandri R., Tдuber M., Martin J. R., Rudolph U., (2002), Neuropharmacology. Sep; 43 (4): 679-84.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Czuczwar S. J., Patsalos P. N. (2001), CNS Drugs. (2001) ; 15 (5): 339–50.,</mixed-citation><mixed-citation xml:lang="en">Czuczwar S. J., Patsalos P. N. (2001), CNS Drugs. (2001) ; 15 (5): 339–50.,</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Czuczwar S. J., Patsalos P. N. (2001), CNS Drugs. 2001; 15 (5): 339–50.,</mixed-citation><mixed-citation xml:lang="en">Czuczwar S. J., Patsalos P. N. (2001), CNS Drugs. 2001; 15 (5): 339–50.,</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Danober L., Deransart C., Depaulis A., Vergnes M., Marescaux C. (1998), Prog Neurobiol. May; 55 (1): 27-57</mixed-citation><mixed-citation xml:lang="en">Danober L., Deransart C., Depaulis A., Vergnes M., Marescaux C. (1998), Prog Neurobiol. May; 55 (1): 27-57</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">De Simone G., Di Fiore A., Menchise V., Pedone C., Antel J., Casini A., Scozzafava A., Wurl M., Supuran CT. (2005) Bioorg. Med. Chem. Lett.; 15 (9): 2315–20.,</mixed-citation><mixed-citation xml:lang="en">De Simone G., Di Fiore A., Menchise V., Pedone C., Antel J., Casini A., Scozzafava A., Wurl M., Supuran CT. (2005) Bioorg. Med. Chem. Lett.; 15 (9): 2315–20.,</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Dodgson S. J., Shank R. P., Maryanoff B. E. (2000), Epilepsia.; 41 (Suppl 1): S35–9,</mixed-citation><mixed-citation xml:lang="en">Dodgson S. J., Shank R. P., Maryanoff B. E. (2000), Epilepsia.; 41 (Suppl 1): S35–9,</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Engel J. Jr. (1996), Epilepsy Res. 1996; 26 (1): 141–50,</mixed-citation><mixed-citation xml:lang="en">Engel J. Jr. (1996), Epilepsy Res. 1996; 26 (1): 141–50,</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Essrich C., Lorez M., Benson J. A., Fritschy J. M., Lьscher B. (1998) Nat Neurosci. Nov; 1 (7): 563-71</mixed-citation><mixed-citation xml:lang="en">Essrich C., Lorez M., Benson J. A., Fritschy J. M., Lьscher B. (1998) Nat Neurosci. Nov; 1 (7): 563-71</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Farrant M., Nusser Z. (2005), Nat Rev Neurosci. Mar; 6 (3): 215-29</mixed-citation><mixed-citation xml:lang="en">Farrant M., Nusser Z. (2005), Nat Rev Neurosci. Mar; 6 (3): 215-29</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Galanopoulou AS, Kyrozis A, Claudio OI, Stanton PK, Moshй SL. (2003), Exp. Neurol.; 183 (2): 628–637</mixed-citation><mixed-citation xml:lang="en">Galanopoulou AS, Kyrozis A, Claudio OI, Stanton PK, Moshй SL. (2003), Exp. Neurol.; 183 (2): 628–637</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Galanopoulou A.S., Vidaurre J., Moshй S.L. (2002), Dev. Neurosci.; 24 (5): 355–63</mixed-citation><mixed-citation xml:lang="en">Galanopoulou A.S., Vidaurre J., Moshй S.L. (2002), Dev. Neurosci.; 24 (5): 355–63</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Galanopoulou A.S., Vidaurre J., Moshй S.L. (2002) . Dev. Neurosci.; 24 (5): 355–63,</mixed-citation><mixed-citation xml:lang="en">Galanopoulou A.S., Vidaurre J., Moshй S.L. (2002) . Dev. Neurosci.; 24 (5): 355–63,</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Galanopoulou AS. (2006) . Eur. J. Neurosci.; 23 (9): 2423–30.</mixed-citation><mixed-citation xml:lang="en">Galanopoulou AS. (2006) . Eur. J. Neurosci.; 23 (9): 2423–30.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gasser T., Reddington M., Schubert P. (1988), Neurosci Lett., Aug 31; 91 (2): 189-93</mixed-citation><mixed-citation xml:lang="en">Gasser T., Reddington M., Schubert P. (1988), Neurosci Lett., Aug 31; 91 (2): 189-93</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ge S., Pradhan D.A., Ming G.L., Song H. (2007), Trends Neurosci. Jan; 30 (1): 1-8.</mixed-citation><mixed-citation xml:lang="en">Ge S., Pradhan D.A., Ming G.L., Song H. (2007), Trends Neurosci. Jan; 30 (1): 1-8.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Gobbi G., Tassinari C.A., Roger J, et al. (1989), Neurol Physiol Clin; 19: 209-18.</mixed-citation><mixed-citation xml:lang="en">Gobbi G., Tassinari C.A., Roger J, et al. (1989), Neurol Physiol Clin; 19: 209-18.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Goffin D., Aarum J., Schroeder J.E., Jovanovic J.N., Chuang T.T. (2008), J. Neurochem. Nov; 107 (4): 964-75</mixed-citation><mixed-citation xml:lang="en">Goffin D., Aarum J., Schroeder J.E., Jovanovic J.N., Chuang T.T. (2008), J. Neurochem. Nov; 107 (4): 964-75</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Granger P., Biton B., Faure C., Vige X., Depoortere H., Graham D., Langer S.Z., Scatton B., Avenet P. (1995), Mol Pharmacol., Jun; 47 (6): 1189-96</mixed-citation><mixed-citation xml:lang="en">Granger P., Biton B., Faure C., Vige X., Depoortere H., Graham D., Langer S.Z., Scatton B., Avenet P. (1995), Mol Pharmacol., Jun; 47 (6): 1189-96</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Granger P., Biton B., Faure C., Vige X., Depoortere H., Graham D., Langer S.Z., Scatton B., Avenet P. (1995), Mol. Pharmacol. 1995; 47 (6): 1189–96</mixed-citation><mixed-citation xml:lang="en">Granger P., Biton B., Faure C., Vige X., Depoortere H., Graham D., Langer S.Z., Scatton B., Avenet P. (1995), Mol. Pharmacol. 1995; 47 (6): 1189–96</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hauser W.A., Annegers J.F., Kurland L.T. (1935-1984) Epilepsia. 34 (3): 453–68,</mixed-citation><mixed-citation xml:lang="en">Hauser W.A., Annegers J.F., Kurland L.T. (1935-1984) Epilepsia. 34 (3): 453–68,</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hauser W.A. (1990) Neurology.; 40 (5 Suppl 2): 9–13,</mixed-citation><mixed-citation xml:lang="en">Hauser W.A. (1990) Neurology.; 40 (5 Suppl 2): 9–13,</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hornung J.P., Fritschy J.M. (1996), J. Comp Neurol. Apr 8; 367 (3): 413-30</mixed-citation><mixed-citation xml:lang="en">Hornung J.P., Fritschy J.M. (1996), J. Comp Neurol. Apr 8; 367 (3): 413-30</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hosford D.A., Wang Y., Cao Z. (1997), Epilepsy Res. Apr; 27 (1): 55-65.</mixed-citation><mixed-citation xml:lang="en">Hosford D.A., Wang Y., Cao Z. (1997), Epilepsy Res. Apr; 27 (1): 55-65.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Khalilov I., Holmes G.L., Ben-Ari Y. (2003) Nat. Neurosci; 6 (10): 1079–85.,</mixed-citation><mixed-citation xml:lang="en">Khalilov I., Holmes G.L., Ben-Ari Y. (2003) Nat. Neurosci; 6 (10): 1079–85.,</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Khalilov I., Le Van Quyen M., Gozlan H., BenAri Y. (2005) Neuron.; 48 (5): 787–96</mixed-citation><mixed-citation xml:lang="en">Khalilov I., Le Van Quyen M., Gozlan H., BenAri Y. (2005) Neuron.; 48 (5): 787–96</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kohling R., Lucke A., Straub H., Speckmann E.J., Tuxhorn I., Wolf P., Pannek H., Oppel F. (1998), Brain; 121 (Pt 6): 1073–87,</mixed-citation><mixed-citation xml:lang="en">Kohling R., Lucke A., Straub H., Speckmann E.J., Tuxhorn I., Wolf P., Pannek H., Oppel F. (1998), Brain; 121 (Pt 6): 1073–87,</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Kostopoulos G., Antoniadis G. (1992) Epilepsy Res.; 8 (Suppl): 125–33</mixed-citation><mixed-citation xml:lang="en">Kostopoulos G., Antoniadis G. (1992) Epilepsy Res.; 8 (Suppl): 125–33</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kume A., Greenfield L.J. Jr., Macdonald R.L., Albin R.L. (1996), J. Pharmacol. Exp. Ther.; 277 (3): 1784–92.,</mixed-citation><mixed-citation xml:lang="en">Kume A., Greenfield L.J. Jr., Macdonald R.L., Albin R.L. (1996), J. Pharmacol. Exp. Ther.; 277 (3): 1784–92.,</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kyrozis A., Chudomel O., Moshй SL., Galanopoulou A.S. (2006). Neurosci. Lett. May 1; 398 (1-2):</mixed-citation><mixed-citation xml:lang="en">Kyrozis A., Chudomel O., Moshй SL., Galanopoulou A.S. (2006). Neurosci. Lett. May 1; 398 (1-2):</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Laure H., (2007), TURUN YLIOPISTON JULKAISUJA ANNALES UNIVERSITATIS TURKUENSIS SARJA – SER. D OSA – TOM. 781</mixed-citation><mixed-citation xml:lang="en">Laure H., (2007), TURUN YLIOPISTON JULKAISUJA ANNALES UNIVERSITATIS TURKUENSIS SARJA – SER. D OSA – TOM. 781</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Leinekugel X., Medina I., Khalilov I., Ben-Ari Y., Khazipov R. Neuron. (1997) Feb; 18 (2): 243-55</mixed-citation><mixed-citation xml:lang="en">Leinekugel X., Medina I., Khalilov I., Ben-Ari Y., Khazipov R. Neuron. (1997) Feb; 18 (2): 243-55</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Liu L., Zheng T., Morris M.J., Wallengren C., Clarke A.L., Reid C.A., Petrou S., O’Brien T.J. (2006), J. Pharmacol Exp Ther. Nov; 319 (2): 790-8.</mixed-citation><mixed-citation xml:lang="en">Liu L., Zheng T., Morris M.J., Wallengren C., Clarke A.L., Reid C.A., Petrou S., O’Brien T.J. (2006), J. Pharmacol Exp Ther. Nov; 319 (2): 790-8.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">LoTurco J.J., Owens D.F., Heath M.J., Davis M.B., Kriegstein A.R. (1995) Neuron. Dec; 15 (6): 1287-98</mixed-citation><mixed-citation xml:lang="en">LoTurco J.J., Owens D.F., Heath M.J., Davis M.B., Kriegstein A.R. (1995) Neuron. Dec; 15 (6): 1287-98</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Loup F., Wieser H.G., Yonekawa Y., Aguzzi A., Fritschy J.M. (2000) . J. Neurosci.; 20 (14): 5401–1948. Masereel B., Rolin S., Abbate F., Scozzafava A., Supuran C.T. (2002) J. Med. Chem.; 45 (2): 312–20,</mixed-citation><mixed-citation xml:lang="en">Loup F., Wieser H.G., Yonekawa Y., Aguzzi A., Fritschy J.M. (2000) . J. Neurosci.; 20 (14): 5401–1948. Masereel B., Rolin S., Abbate F., Scozzafava A., Supuran C.T. (2002) J. Med. Chem.; 45 (2): 312–20,</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Mathern G.W., Pretorius JK, Babb T.L. (1995), J. Neurosurg; 82 (2): 220–7</mixed-citation><mixed-citation xml:lang="en">Mathern G.W., Pretorius JK, Babb T.L. (1995), J. Neurosurg; 82 (2): 220–7</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Meldrum B.S., Rogawski MA. (2007), Neurotherapeatics; 4 (1): 18–61</mixed-citation><mixed-citation xml:lang="en">Meldrum B.S., Rogawski MA. (2007), Neurotherapeatics; 4 (1): 18–61</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Meldrum B.S., Rogawski M.A. (2007), Neurotherapeatics; 4 (1): 18–61.,</mixed-citation><mixed-citation xml:lang="en">Meldrum B.S., Rogawski M.A. (2007), Neurotherapeatics; 4 (1): 18–61.,</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Mhler H. (2006), Cell Tissue Res. Nov; 326 (2): 505-16.</mixed-citation><mixed-citation xml:lang="en">Mhler H. (2006), Cell Tissue Res. Nov; 326 (2): 505-16.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Mosh S.L. Epileptogenesis and the immature brain. (1987) Epilepsia; 28 (Suppl1): S3–15</mixed-citation><mixed-citation xml:lang="en">Mosh S.L. Epileptogenesis and the immature brain. (1987) Epilepsia; 28 (Suppl1): S3–15</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Moshй S.L. Epileptogenesis and the immature brain. Epilepsia. 1987; 28 (Suppl1): S3–15.</mixed-citation><mixed-citation xml:lang="en">Moshй S.L. Epileptogenesis and the immature brain. Epilepsia. 1987; 28 (Suppl1): S3–15.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Munakata M., Watanabe M., Otsuki T., Nakama H., Arima K., Itoh M., Nabekura J., Iinuma K., Tsuchiya S. (2007), Epilepsia.; 48 (4): 837–44</mixed-citation><mixed-citation xml:lang="en">Munakata M., Watanabe M., Otsuki T., Nakama H., Arima K., Itoh M., Nabekura J., Iinuma K., Tsuchiya S. (2007), Epilepsia.; 48 (4): 837–44</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Nett S.Т., Jorge-Rivera J.C., Myers M., Clark A.S., Henderson L.P. (1999), J. Neurophysiol; 81 (1): 192–203</mixed-citation><mixed-citation xml:lang="en">Nett S.Т., Jorge-Rivera J.C., Myers M., Clark A.S., Henderson L.P. (1999), J. Neurophysiol; 81 (1): 192–203</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Nishimori I., Vullo D., Innocenti A., Scozzafava A., Mastrolorenzo A., Supuran C.T. (2005) . Bioorg. Med. Chem. Lett.; 15 (17): 3828–33,</mixed-citation><mixed-citation xml:lang="en">Nishimori I., Vullo D., Innocenti A., Scozzafava A., Mastrolorenzo A., Supuran C.T. (2005) . Bioorg. Med. Chem. Lett.; 15 (17): 3828–33,</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Okabe A., Ohno K., Toyoda H., Yokokura M., Sato K., Fukuda A. (2002) Neurosci. Res.; 44 (2): 225–9</mixed-citation><mixed-citation xml:lang="en">Okabe A., Ohno K., Toyoda H., Yokokura M., Sato K., Fukuda A. (2002) Neurosci. Res.; 44 (2): 225–9</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Okabe A., Yokokura M., Toyoda H., ShimizuOkabe C., Ohno K., Sato K., Fukuda A. (2003), Brain Res. 2003; 990 (1-2): 221–6</mixed-citation><mixed-citation xml:lang="en">Okabe A., Yokokura M., Toyoda H., ShimizuOkabe C., Ohno K., Sato K., Fukuda A. (2003), Brain Res. 2003; 990 (1-2): 221–6</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Okabe A., Yokokura M., Toyoda H., ShimizuOkabe C., Ohno K., Sato K., Fukuda A. (2003). Brain Res.; 990 (1-2): 221–6</mixed-citation><mixed-citation xml:lang="en">Okabe A., Yokokura M., Toyoda H., ShimizuOkabe C., Ohno K., Sato K., Fukuda A. (2003). Brain Res.; 990 (1-2): 221–6</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Olpe H., Kolb C.N., Hausdorf A., Haas H.L. (1991), Experientia, Mar 15; 47 (3): 254-7.</mixed-citation><mixed-citation xml:lang="en">Olpe H., Kolb C.N., Hausdorf A., Haas H.L. (1991), Experientia, Mar 15; 47 (3): 254-7.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Palma E., Amici M., Sobrero F., Spinelli G., Di Angelantonio S., Ragozzino D., Mascia A., Scoppetta C., Esposito V., Miledi R., Eusebi F. (2006), Proc. Natl. Acad. Sci. USA.; 103 (22): 8465–8.)</mixed-citation><mixed-citation xml:lang="en">Palma E., Amici M., Sobrero F., Spinelli G., Di Angelantonio S., Ragozzino D., Mascia A., Scoppetta C., Esposito V., Miledi R., Eusebi F. (2006), Proc. Natl. Acad. Sci. USA.; 103 (22): 8465–8.)</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Perucca E., Gram L., Avanzini G., Dulac O., (1998), Epilepsia., Jan; 39 (1): 5-17.</mixed-citation><mixed-citation xml:lang="en">Perucca E., Gram L., Avanzini G., Dulac O., (1998), Epilepsia., Jan; 39 (1): 5-17.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Pirker S., Schwarzer C., Wieselthaler A., Sieghart W., Sperk G. (2000), Neuroscience.; 101 (4): 815-50</mixed-citation><mixed-citation xml:lang="en">Pirker S., Schwarzer C., Wieselthaler A., Sieghart W., Sperk G. (2000), Neuroscience.; 101 (4): 815-50</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Quilichini P.P., Chiron C., Ben-Ari Y., Gozlan H. (2006), Epilepsia.; 47 (4): 704–16</mixed-citation><mixed-citation xml:lang="en">Quilichini P.P., Chiron C., Ben-Ari Y., Gozlan H. (2006), Epilepsia.; 47 (4): 704–16</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Ravizza T., Friedman L.K., Moshй S.L., Veliskova J. (2003) Int. J. Dev. Neurosci. 2003; 21 (5): 245–54</mixed-citation><mixed-citation xml:lang="en">Ravizza T., Friedman L.K., Moshй S.L., Veliskova J. (2003) Int. J. Dev. Neurosci. 2003; 21 (5): 245–54</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Reiss W.G., Oles K.S. (1996) . Ann. Pharmacother.; 30 (5): 514–9</mixed-citation><mixed-citation xml:lang="en">Reiss W.G., Oles K.S. (1996) . Ann. Pharmacother.; 30 (5): 514–9</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Rivera C., Li H., Thomas-Crusells J., Lahtinen H., Viitanen T., Nanobashvili A., Kokaia Z., Airaksinen M.S., Voipio J., Kaila K., Saarma M. (2002) . J. Cell Biol. 2002; 159 (5): 747–52</mixed-citation><mixed-citation xml:lang="en">Rivera C., Li H., Thomas-Crusells J., Lahtinen H., Viitanen T., Nanobashvili A., Kokaia Z., Airaksinen M.S., Voipio J., Kaila K., Saarma M. (2002) . J. Cell Biol. 2002; 159 (5): 747–52</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Rivera C., Voipio J., Kaila K.. (2005), J. Physiol. Jan 1; 562 (Pt 1): 27-36.</mixed-citation><mixed-citation xml:lang="en">Rivera C., Voipio J., Kaila K.. (2005), J. Physiol. Jan 1; 562 (Pt 1): 27-36.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Rivera C., Voipio J., Payne J.A., Ruusuvuori E., Lahtinen H., Lamsa K., Pirvola U., Saarma M., Kaila K. (1999), Nature. Jan 21; 397 (6716): 251-5.</mixed-citation><mixed-citation xml:lang="en">Rivera C., Voipio J., Payne J.A., Ruusuvuori E., Lahtinen H., Lamsa K., Pirvola U., Saarma M., Kaila K. (1999), Nature. Jan 21; 397 (6716): 251-5.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Rudolph U., Crestani F., Benke D., Brьnig I., Benson J.A., Fritschy J.M., Martin J.R., Bluethmann H., Mцhler H. (1999), Nature. Oct 21; 401 (6755): 796-800.</mixed-citation><mixed-citation xml:lang="en">Rudolph U., Crestani F., Benke D., Brьnig I., Benson J.A., Fritschy J.M., Martin J.R., Bluethmann H., Mцhler H. (1999), Nature. Oct 21; 401 (6755): 796-800.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Schirrmacher K., Mayer A., Walden J., Dьsing R., Bingmann D. (1995), Eur Neuropsychopharmacol. Dec; 5 (4): 501-7.</mixed-citation><mixed-citation xml:lang="en">Schirrmacher K., Mayer A., Walden J., Dьsing R., Bingmann D. (1995), Eur Neuropsychopharmacol. Dec; 5 (4): 501-7.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Tozuka Y., Fukuda S., Namba T., Seki T., Hisatsune T. (2005), Neuron. Sep 15; 47 (6): 803-15.</mixed-citation><mixed-citation xml:lang="en">Tozuka Y., Fukuda S., Namba T., Seki T., Hisatsune T. (2005), Neuron. Sep 15; 47 (6): 803-15.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Tuckel K., Jasper H. (1952), Electroencephalogr Clin Neurophysiol; 4: 481-94;</mixed-citation><mixed-citation xml:lang="en">Tuckel K., Jasper H. (1952), Electroencephalogr Clin Neurophysiol; 4: 481-94;</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D.D., Kriegstein A.R. (2009), J. Physiol. May 1; 587 (Pt 9): 1873-9 76. Willow M., Gonoi T., Catterall W.A., (1985), Mol Pharmacol., May; 27 (5): 549-58.</mixed-citation><mixed-citation xml:lang="en">Wang D.D., Kriegstein A.R. (2009), J. Physiol. May 1; 587 (Pt 9): 1873-9 76. Willow M., Gonoi T., Catterall W.A., (1985), Mol Pharmacol., May; 27 (5): 549-58.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Yuste R., Katz L.C. (1991), Neuron. Mar; 6 (3): 333-44</mixed-citation><mixed-citation xml:lang="en">Yuste R., Katz L.C. (1991), Neuron. Mar; 6 (3): 333-44</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Glauser T., Ben-Menachem E., Bourgeois B., et al. ILAE treatment guidelines: evidencebased analysis of antiepileptic drug efficacy and effectiveness as initia monotherapy for epileptic seizures and syndromes. Epilepsia 2006; 47: 1094-1120.</mixed-citation><mixed-citation xml:lang="en">Glauser T., Ben-Menachem E., Bourgeois B., et al. ILAE treatment guidelines: evidencebased analysis of antiepileptic drug efficacy and effectiveness as initia monotherapy for epileptic seizures and syndromes. Epilepsia 2006; 47: 1094-1120.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Wheless J.W., Clarke D.F., Carpenter D. Treatment of pediatric epilepsy: expert opinion, 2005. J. Child Neurol 2005; 20 (suppl 1): S1–56.</mixed-citation><mixed-citation xml:lang="en">Wheless J.W., Clarke D.F., Carpenter D. Treatment of pediatric epilepsy: expert opinion, 2005. J. Child Neurol 2005; 20 (suppl 1): S1–56.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
