<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">epilepsia-213</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>Incidence rate of different forms of idiopathic childhood focal epilepsy</article-title><trans-title-group xml:lang="ru"><trans-title>Эпилептический негативный миоклонус</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухин</surname><given-names>К. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhin</surname><given-names>K. Yu.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронов</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironov</surname><given-names>M. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кваскова</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>.</surname><given-names>.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Какаулина</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>.</surname><given-names>.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмич</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>.</surname><given-names>.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Глухова</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>.</surname><given-names>.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чадаев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>.</surname><given-names>.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боровиков</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>.</surname><given-names>.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт детской неврологии и эпилепсии имени Святителя Луки</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Luke Institute of pediatric neurology and epilepsy, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff xml:lang="ru" id="aff-2"><institution>ФУВ ГОУ ВПО РГМУ им. Н.И. Пирогова Росздрава</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2016</year></pub-date><volume>3</volume><issue>2</issue><fpage>15</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Mukhin K.Y., Mironov M.B., . ..Е., . ..С., . ..В., . ..Ю., . ..А., . ..С., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Мухин К.Ю., Миронов М.Б., Кваскова Н.Е., Какаулина В.С., Кузьмич Г.В., Глухова Л.Ю., Чадаев В.А., Боровиков К.С.</copyright-holder><copyright-holder xml:lang="en">Mukhin K.Y., Mironov M.B., . .., . .., . .., . .., . .., . ..</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/213">https://www.epilepsia.su/jour/article/view/213</self-uri><abstract><p>The structure of idiopathic focal forms of epilepsy was investigated on 1118 patients with diagnosis of epilepsy, and aged from the first days of life to 18 years. Their age enabled to monitor the debut of seizures. The methods of investigation included clinical examination, video EEG-monitoring, testing by neuropsychologist and, when necessary, neurovisualization. In 189 cases (16.9% of the total number of patients with the debut of seizures before 18) the idiopathic focal epilepsy forms were diagnosed. In 99 cases (8.8% of patients) the diagnosis was Idiopathic focal epilepsy (IFE) with central temporal spikes. The idiopathic occipital lobe epilepsy (IOE) was found in 47 patients (4.2 % of cases). IFE with pseudo-generalized seizures (IFEPGS) was observed in 31 patients (2.8% of cases). The idiopathic focal epilepsy of infancy (IFEI) was seen in 5 cases which equals to 0.5% of the total patient group. The idiopathic focal epilepsy with affective symptoms (IFEAS) was diagnosed in 7 patients (0.6%). Rolandic epilepsy was most frequently found in the IFE group (52.4% of cases). The idiopathic occipital lobe epilepsy was diagnosed in 24.9% of cases. The IFE-PGS was seen in 16.4% of patients, IFEAS - in 3.7% of cases, and IFEI - in 2.6% of cases. By and large, the results are in line with those obtained in the majority of foreign studies on the incidence rate of the idiopathic focal epilepsy forms.</p></abstract><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>ЭПИЛЕПСИЯ</kwd><kwd>ЭПИЛЕПТИЧЕСКИЙ НЕГАТИВНЫЙ МИОКЛОНУС</kwd><kwd>ВИДЕО-ЭЭГ МОНИТОРИНГ</kwd><kwd>ЭПИЛЕПТИЧЕСКАЯ ЭНЦЕФАЛОПАТИЯ</kwd><kwd>ДЭПД</kwd></kwd-group><kwd-group xml:lang="en"><kwd>IDIOPATHIC FOCAL EPILEPSY</kwd><kwd>INCIDENCE RATE</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Зенков Л. Р. Утяжеление течения эпилепсии, связанное с противосудорожной фармакотерапией. Журнал Неврологии и Психиатрии им. С. С. Корсакова, 2005. 105, №10, с. 52-54</mixed-citation><mixed-citation xml:lang="en">Зенков Л. Р. Утяжеление течения эпилепсии, связанное с противосудорожной фармакотерапией. Журнал Неврологии и Психиатрии им. С. С. Корсакова, 2005. 105, №10, с. 52-54</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Карлов В. А., Овнатанов Б. С. Медиобазальные эпилептиформные очаги и абсансная активность на ЭЭГ // Журн. невропатол. и психиатр. – 1987. – Т. 87, № 6. – С. 805—812</mixed-citation><mixed-citation xml:lang="en">Карлов В. А., Овнатанов Б. С. Медиобазальные эпилептиформные очаги и абсансная активность на ЭЭГ // Журн. невропатол. и психиатр. – 1987. – Т. 87, № 6. – С. 805—812</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин К. Ю. Идиопатическая фокальная эпилепсия с псевдогенерализованными приступами – особая форма эпилепсии в детском возрасте. // Русский журнал детской неврологии. 2009. Т. 4. № 2. С. 3-19.</mixed-citation><mixed-citation xml:lang="en">Мухин К. Ю. Идиопатическая фокальная эпилепсия с псевдогенерализованными приступами – особая форма эпилепсии в детском возрасте. // Русский журнал детской неврологии. 2009. Т. 4. № 2. С. 3-19.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин К. Ю., Миронов М. Б., Боровиков К. С., Петрухин А. С. Фокальная эпилепсия детского возраста со структурными изменениями в мозге и доброкачественными эпилептиформными паттернами на ЭЭГ (ФЭДСИМ-ДЭПД) (предварительные результаты) // Русский журнал детской неврологии. – 2010. – Т. 5. – №1– С. 3-18.</mixed-citation><mixed-citation xml:lang="en">Мухин К. Ю., Миронов М. Б., Боровиков К. С., Петрухин А. С. Фокальная эпилепсия детского возраста со структурными изменениями в мозге и доброкачественными эпилептиформными паттернами на ЭЭГ (ФЭДСИМ-ДЭПД) (предварительные результаты) // Русский журнал детской неврологии. – 2010. – Т. 5. – №1– С. 3-18.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин К. Ю., Миронов М. Б., Тысячина М. Д., Алиханов А. А., Петрухин А. С. Электро-клиническая характеристика больных симптоматической фокальной эпилепсией с феноменом вторичной билатеральной синхронизации на ЭЭГ. // Русский журнал детской неврологии, 2006, том 1 выпуск 1, стр. 6-17.</mixed-citation><mixed-citation xml:lang="en">Мухин К. Ю., Миронов М. Б., Тысячина М. Д., Алиханов А. А., Петрухин А. С. Электро-клиническая характеристика больных симптоматической фокальной эпилепсией с феноменом вторичной билатеральной синхронизации на ЭЭГ. // Русский журнал детской неврологии, 2006, том 1 выпуск 1, стр. 6-17.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин К. Ю., Петрухин А. С. Идиопатические формы эпилепсии: систематика, диагностика, терапия. – М. : Арт- Бизнес-Центр, 2000. – 319 с.</mixed-citation><mixed-citation xml:lang="en">Мухин К. Ю., Петрухин А. С. Идиопатические формы эпилепсии: систематика, диагностика, терапия. – М. : Арт- Бизнес-Центр, 2000. – 319 с.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Capovilla G, Beccaria F, Veggiotti P, Rubboli G, Meletti S, Tassinari CA. Ethosuximide is effective in the treatment of epileptic negative myoclonus in childhood partial epilepsy. J Child Neurol. 1999 Jun;14(6):395-400.</mixed-citation><mixed-citation xml:lang="en">Capovilla G, Beccaria F, Veggiotti P, Rubboli G, Meletti S, Tassinari CA. Ethosuximide is effective in the treatment of epileptic negative myoclonus in childhood partial epilepsy. J Child Neurol. 1999 Jun;14(6):395-400.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Capovilla G, Rubboli G, Beccaria F, Meregalli S, Veggiotti P, Giambelli PM, Meletti S, Tassinari CA. Intermittent falls and fecal incontinence as a manifestation of epileptic negative myoclonus in idiopathic partial epilepsy of childhood. Neuropediatrics. 2000 Oct;31(5):273-5.</mixed-citation><mixed-citation xml:lang="en">Capovilla G, Rubboli G, Beccaria F, Meregalli S, Veggiotti P, Giambelli PM, Meletti S, Tassinari CA. Intermittent falls and fecal incontinence as a manifestation of epileptic negative myoclonus in idiopathic partial epilepsy of childhood. Neuropediatrics. 2000 Oct;31(5):273-5.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dalla Bernardina B, Fontana E, Michelizza B, Colamaria V, Capovilla G, Tassinari CA. Partial epilepsies of childhood, bilateral</mixed-citation><mixed-citation xml:lang="en">Dalla Bernardina B, Fontana E, Michelizza B, Colamaria V, Capovilla G, Tassinari CA. Partial epilepsies of childhood, bilateral</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">synchronization, continuous spike-wave during slow sleep. In: Manelis J, Bental E, Loeber JN, Dreifuss FE, editors. Advances in epileptology. XVIIth Epilepsy International Symposium. Raven Press, New York; 1989:295-302.</mixed-citation><mixed-citation xml:lang="en">synchronization, continuous spike-wave during slow sleep. In: Manelis J, Bental E, Loeber JN, Dreifuss FE, editors. Advances in epileptology. XVIIth Epilepsy International Symposium. Raven Press, New York; 1989:295-302.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Guerrini R, Dravet C, Genton P, et al. Epileptic negative myoclonus. Neurology 1993;43(6):1078-83</mixed-citation><mixed-citation xml:lang="en">Guerrini R, Dravet C, Genton P, et al. Epileptic negative myoclonus. Neurology 1993;43(6):1078-83</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Guzzetta F, Battaglia D, Lettori D, Deodato F, Sani E, Rand T, Ricci D, Acquafondata C, Faienza C. Epileptic negative myoclonus in a newborn with hemimegalencephaly. Epilepsia. 2002 Sep;43(9):1106-9.</mixed-citation><mixed-citation xml:lang="en">Guzzetta F, Battaglia D, Lettori D, Deodato F, Sani E, Rand T, Ricci D, Acquafondata C, Faienza C. Epileptic negative myoclonus in a newborn with hemimegalencephaly. Epilepsia. 2002 Sep;43(9):1106-9.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hahn A., Fischenbeck A., Stephani U. Induction of epileptic negative myoclonus by oxcarbazepine in symptomaticepilepsy. Epileptic Disord. 2004 Dec;6(4):271-4.</mixed-citation><mixed-citation xml:lang="en">Hahn A., Fischenbeck A., Stephani U. Induction of epileptic negative myoclonus by oxcarbazepine in symptomaticepilepsy. Epileptic Disord. 2004 Dec;6(4):271-4.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nabbout R, Dulac O. Epileptic encephalopathies: a brief overview. J Clin Neurophysiol 2003;20:393-7</mixed-citation><mixed-citation xml:lang="en">Nabbout R, Dulac O. Epileptic encephalopathies: a brief overview. J Clin Neurophysiol 2003;20:393-7</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Nanba Y, Maegaki Y. Epileptic negative myoclonus induced by carbamazepine in a child with BECTS. Benign childhood epilepsy with centrotemporal spikes. Pediatr Neurol. 1999 Sep;21(3):664-7.</mixed-citation><mixed-citation xml:lang="en">Nanba Y, Maegaki Y. Epileptic negative myoclonus induced by carbamazepine in a child with BECTS. Benign childhood epilepsy with centrotemporal spikes. Pediatr Neurol. 1999 Sep;21(3):664-7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Oguni H, Uehara T, Tanaka T, Sunahara M, Hara M, Osawa M. Dramatic effect of ethosuximide on epileptic negative myoclonus: implications for the neurophysiological mechanism. Neuropediatrics. 1998 Feb;29(1):29-34.</mixed-citation><mixed-citation xml:lang="en">Oguni H, Uehara T, Tanaka T, Sunahara M, Hara M, Osawa M. Dramatic effect of ethosuximide on epileptic negative myoclonus: implications for the neurophysiological mechanism. Neuropediatrics. 1998 Feb;29(1):29-34.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Parmeggiani L, Seri S, Bonanni P, Guerrini R. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negative myoclonus in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol. 2004 Jan;115(1):50-8</mixed-citation><mixed-citation xml:lang="en">Parmeggiani L, Seri S, Bonanni P, Guerrini R. Electrophysiological characterization of spontaneous and carbamazepine-induced epileptic negative myoclonus in benign childhood epilepsy with centro-temporal spikes. Clin Neurophysiol. 2004 Jan;115(1):50-8</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tassinari CA, Regis H, Gastaut H. A particular form of muscular inhibition in epilepsy: the related epileptic silent period (R. E. S. P.). Proc Aust Assoc Neurol 1968;5(3):595-602.</mixed-citation><mixed-citation xml:lang="en">Tassinari CA, Regis H, Gastaut H. A particular form of muscular inhibition in epilepsy: the related epileptic silent period (R. E. S. P.). Proc Aust Assoc Neurol 1968;5(3):595-602.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tassinari CA, Rubboli G, Parmeggiani L, Valzania F, Plasmati R, Riguzzi P, Michelucci R, Volpi L, Passarelli D, Meletti S, et al. Epileptic negative myoclonus. Adv Neurol. 1995;67:181-97.</mixed-citation><mixed-citation xml:lang="en">Tassinari CA, Rubboli G, Parmeggiani L, Valzania F, Plasmati R, Riguzzi P, Michelucci R, Volpi L, Passarelli D, Meletti S, et al. Epileptic negative myoclonus. Adv Neurol. 1995;67:181-97.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Tassinari CA, Rubboli G, Volpi L, Billard C, Bureau M. Electrical status epilepticus during slow sleep (ESES or CSWS) including acquired epileptic aphasia (Landau-Kleffner syndrome). In: Roger J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P, editors. Epileptic syndromes in infancy, childhood and adolescence, 3rd ed. John Libbey &amp; Co: London; 2002:265-83.</mixed-citation><mixed-citation xml:lang="en">Tassinari CA, Rubboli G, Volpi L, Billard C, Bureau M. Electrical status epilepticus during slow sleep (ESES or CSWS) including acquired epileptic aphasia (Landau-Kleffner syndrome). In: Roger J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P, editors. Epileptic syndromes in infancy, childhood and adolescence, 3rd ed. John Libbey &amp; Co: London; 2002:265-83.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Werhahn KJ, Noachtar S. Epileptic negative myoclonus. In:. Suders HO, Noachtar S, editors. Epileptic seizures. Pathophysiology and clinical semiology. Philadelphia: Churchill Livingstone; 2000:473-83</mixed-citation><mixed-citation xml:lang="en">Werhahn KJ, Noachtar S. Epileptic negative myoclonus. In:. Suders HO, Noachtar S, editors. Epileptic seizures. Pathophysiology and clinical semiology. Philadelphia: Churchill Livingstone; 2000:473-83</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
