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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">epilepsia-217</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>ANALYSIS OF THE SERT AND TPH2 GENES POLYMORPHISM RELATIONSHIP WITH SIDE EFFECTS DURING TOPIRAMATE THERAPY TAKING INTO ACCOUNT GENDER FEATURES</article-title><trans-title-group xml:lang="ru"><trans-title>АНАЛИЗ СВЯЗИ ПОЛИМОРФИЗМОВ ГЕНОВ SERT И TPH2 С ПОБОЧНЫМИ ЭФФЕКТАМИ НА ФОНЕ ТЕРАПИИ ТОПИРАМАТОМ С УЧЕТОМ ГЕНДЕРНЫХ ОСОБЕННОСТЕЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чуканова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Chukanova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра неврологии и нейрохирургии</p></bio><bio xml:lang="en"><p>Department of Neurology and Neurosurgery</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тушканов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tushkanov</surname><given-names>M. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барский</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Barsky</surname><given-names>V. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Граждан</surname><given-names>И. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Grazhdan</surname><given-names>I. K.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крикова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Cricova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>лаб. клинической генетики</p></bio><bio xml:lang="en"><p>Clinical Genetics laboratory</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аксенова</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Aksenova</surname><given-names>M. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурд</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Burd</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра неврологии и нейрохирургии</p></bio><bio xml:lang="en"><p>Department of Neurology and Neurosurgery</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гусев</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gusev</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра неврологии и нейрохирургии</p></bio><bio xml:lang="en"><p>Department of Neurology and Neurosurgery</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГОУ ВПО РГМУ Росздрава им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian State Medical University named after N.I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Научно-исследовательский институт экологии человека и гигиены окружающей среды им А.Н. Сысина» Министерства здравоохраненияи социального развития Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FSO, «Research Institute of Human Ecology and Environmental Hygiene named after A.N. Sysina» of the Ministry of Health and Social Development</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГОУ ВПО Первый Московский Государственный Медицинский Университет имени И.М. Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University named after I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Научный центр психического здоровья РАМН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The Scientific Center of Mental Health, RAMS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>30</day><month>08</month><year>2016</year></pub-date><volume>3</volume><issue>2</issue><fpage>45</fpage><lpage>54</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Chukanova A.S., Tushkanov M.A., Barsky V.I., Grazhdan I.K., Cricova E.V., Aksenova M.G., Burd S.G., Gusev E.I., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Чуканова А.С., Тушканов М.А., Барский В.И., Граждан И.К., Крикова Е.В., Аксенова М.Г., Бурд С.Г., Гусев Е.И.</copyright-holder><copyright-holder xml:lang="en">Chukanova A.S., Tushkanov M.A., Barsky V.I., Grazhdan I.K., Cricova E.V., Aksenova M.G., Burd S.G., Gusev E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/217">https://www.epilepsia.su/jour/article/view/217</self-uri><abstract/><trans-abstract xml:lang="ru"/><kwd-group xml:lang="ru"><kwd>фармакогенетика эпилепсии</kwd><kwd>побочных эффектов топирамата</kwd><kwd>ген SERT</kwd><kwd>ген ТРН2</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pharmacogenetics of epilepsy</kwd><kwd>topiramate side effects</kwd><kwd>SERT</kwd><kwd>TRN2</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Белова А.Н., Шепетова О.Н. 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