epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLCepilepsia-234Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИEPILEPSY AND PINEAL HORMONE: CURRENT STATE OF THE PROBLEMЭПИЛЕПСИЯ И ГОРМОН ЭПИФИЗА: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫОлейниковаО. М.OleynikovaO. M.КареваЕ. Н.KarevaE. N.БогомазоваМ. А.BogomazovaM. A.АвакянГ. Г.AvakyanG. G.ЛагутинЮ. В.LagutinYu. V.АвакянГ. Н.AvakyanG. N.ГБОУ ВПО «Российский Национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздравсоцразвития РоссииРоссияSBEI HPE «RNSMU named after N.I. Pirogov» Ministry of Healthcare and Social Development of RussiaRussian Federation201131082016342227Copyright © Oleynikova O.M., Kareva E.N., Bogomazova M.A., Avakyan G.G., Lagutin Y.V., Avakyan G.N., 20162016Олейникова О.М., Карева Е.Н., Богомазова М.А., Авакян Г.Г., Лагутин Ю.В., Авакян Г.Н.Oleynikova O.M., Kareva E.N., Bogomazova M.A., Avakyan G.G., Lagutin Y.V., Avakyan G.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/234

The pineal gland hormone melatonin is the main regulator of biological rhythms. It affects sleep, brain bioelectric activity and seizures. The majority of experimental and clinical studies are confirmed the anticonvulsant properties of melatonin. However, in the scientific literature there is no data on the concentration of melatonin in adult patients with epilepsy and epileptic syndromes. Thus study of melatonin in adult patients was developed. The evening (1 hour before bedtime), night concentrations (morning), and excretion of melatonin in 54 patients with focal symptomatic epilepsy at the age of 21 to 47 years were evaluated. It was found that seizures provoke a decrease of melatonin concentration.

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The authors declare that there are no conflicts of interest present.