epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLCepilepsia-273Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИEXPERIENCE WITH USE OF CHRONIC NEUROSTIMULATION OF VAGUS NERVE IN TREATMENT OF PHARMACORESISTANT EPILEPSYОПЫТ ПРИМЕНЕНИЯ ХРОНИЧЕСКОЙ НЕЙРОСТИМУЛЯЦИИ БЛУЖДАЮЩЕГО НЕРВА В ЛЕЧЕНИИ ФАРМАКОРЕЗИСТЕНТНОЙ ЭПИЛЕПСИИСуфиановА. А.SufianovА. А.ОрловА. С.OrlovА. S.МатвеевЕ. И.MatveevЕ. I.ЛебедеваД. И.LebedevaD. I.ФГБУ Федеральный центр нейрохирургии, ТюменьРоссияFederal state-funded institution «Federal center of neurosurgery», TumenRussian FederationГАУЗ ТО Областная клиническая больница восстановительного лечения, ТюменьРоссияState autonomous healthcare institution of Tumen region, Regional clinical hospital of medical rehabilitation, TumenRussian Federation201206092016434849Copyright © Sufianov А.А., Orlov А.S., Matveev Е.I., Lebedeva D.I., 20162016Суфианов А.А., Орлов А.С., Матвеев Е.И., Лебедева Д.И.Sufianov А.А., Orlov А.S., Matveev Е.I., Lebedeva D.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/273

This article presents the results of vagus nerve chronic stimulation in 11 patients with pharmacoresistant epilepsy who are not on the wait-list for direct surgical treatment. During the first three months of nervestimulation 27,3% of patients demonstrated a 50% seizure-frequency reduction as compared to baseline, with no surgical or infectious complications. 27,3% Of patients demonstrated transient side effects of nerve stimulation, such as dysphonia, trouble breathing or throat paresthesias.

стимуляция блуждающего нервафармакорезистентная эпилепсияvagus nerve chronic stimulationpharmacoresistant epilepsyReferencesAmar A.P., Apuzzo Michael L.J., Liu Charles Y. Vagus nerve stimulation therapy after failed cranial surgery for intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. Neurosurgery. 2004, 55:1086-1093.Amar A.P., Apuzzo Michael L.J., Liu Charles Y. Vagus nerve stimulation therapy after failed cranial surgery for intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. Neurosurgery. 2004, 55:1086-1093.Annegers J.F. et al. Epilepsy, vagal nerve stimulation by the NCP system, mortality, and sudden, unexpected, unexplained death. Epilepsia. 1998; 39: 206-212.Annegers J.F. et al. Epilepsy, vagal nerve stimulation by the NCP system, mortality, and sudden, unexpected, unexplained death. Epilepsia. 1998; 39: 206-212.Binnie C.D. Vagus nerve stimulation for epilepsy: a review. Seizure. 2000; 9 (3): 161-169.Binnie C.D. Vagus nerve stimulation for epilepsy: a review. Seizure. 2000; 9 (3): 161-169.Brodie M.L., Kwan P. Neurology. 2002; 58 (suppl. 5): 2-8.Brodie M.L., Kwan P. Neurology. 2002; 58 (suppl. 5): 2-8.Kwan P., Brodie M.J.. Early identification of refractory epilepsy. New England Journal of Medicine. 2002; 342 (5): 314-319.Kwan P., Brodie M.J.. Early identification of refractory epilepsy. New England Journal of Medicine. 2002; 342 (5): 314-319.Lhatoo S.D. et al. Sudden unexpected death in epilepsy. Postgrad. Med. J. 1999; 75: 706- 709.Lhatoo S.D. et al. Sudden unexpected death in epilepsy. Postgrad. Med. J. 1999; 75: 706- 709.Meador K.J. Neurology. 2002; 58 (suppl 5): 21-26.Meador K.J. Neurology. 2002; 58 (suppl 5): 21-26.Mohanraj R., Brodie M.J. Diagnosing intractable epilepsy: response to sequential treatment schedules. Eur. J. Neurol. 2006; 13: 277-282.Mohanraj R., Brodie M.J. Diagnosing intractable epilepsy: response to sequential treatment schedules. Eur. J. Neurol. 2006; 13: 277-282.National Institutes of Health Consensus Conference: Surgery for epilepsy. JAMA 264. 1990; 729-733.National Institutes of Health Consensus Conference: Surgery for epilepsy. JAMA 264. 1990; 729-733.Renfroe J.B., Whelees J.W. Earlier use of an adjunctive vagus nerve stimulation therapy for refractory epilepsy. Neurology. 2002; Sept., 59 (4).Renfroe J.B., Whelees J.W. Earlier use of an adjunctive vagus nerve stimulation therapy for refractory epilepsy. Neurology. 2002; Sept., 59 (4).Shahwan A., Bailey C., Maxiner W., Harvey A.S. Vagus nerve stimulation for refractory epilepsy in children: More to VNS then seizure frequency reduction. Epilepsia. 2009; Sept., 50(5): 1220-1228.Shahwan A., Bailey C., Maxiner W., Harvey A.S. Vagus nerve stimulation for refractory epilepsy in children: More to VNS then seizure frequency reduction. Epilepsia. 2009; Sept., 50(5): 1220-1228.The Vagus Nerve Stimulation Study Group: A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology. 1995; 45: 224-230.The Vagus Nerve Stimulation Study Group: A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology. 1995; 45: 224-230.Van Ness P.C. Therapy for the epilepsies. Arch. Neurol. 2002; 59: 732-735.Van Ness P.C. Therapy for the epilepsies. Arch. Neurol. 2002; 59: 732-735.Wheless J.W., Maggio V. Vagus nerve stimulation therapy in patients younger than 18 years. Neurology. 2002; 59 (4): 21-25.Wheless J.W., Maggio V. Vagus nerve stimulation therapy in patients younger than 18 years. Neurology. 2002; 59 (4): 21-25.

The authors declare that there are no conflicts of interest present.