<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2077-8333.2016.8.4.034-038</article-id><article-id custom-type="elpub" pub-id-type="custom">epilepsia-315</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>EPILEPSY IN CHILDREN WITH STROKE</article-title><trans-title-group xml:lang="ru"><trans-title>ЭПИЛЕПСИЯ У ДЕТЕЙ С ОСТРЫМИ НАРУШЕНИЯМИ МОЗГОВОГО КРОВООБРАЩЕНИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халилова</surname><given-names>А. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalilova</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры неврологии, детской неврологии и медицинской генетики, заведующая отделением детской неврологии клиники,</p><p>ул. Богишамол 223, Юнусабадский район, Ташкент, 100140</p></bio><bio xml:lang="en"><p>MD, PhD, assistant professor of neurology, pediatric neurology and medical genetics TashPMI, Head of the Division of Pediatric Neurology Clinic,</p><p>ul. Bogishamol, 223, Yunusabadskii raion, Tashkent, 100140</p></bio><email xlink:type="simple">halilova_alie@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маджидова</surname><given-names>Ё. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Madjidova</surname><given-names>Yo. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., заведующая кафедрой неврологии, детской неврологии и медицинской генетики, профессор, зам. председателя ассоциации неврологов Узбекистана, ул. Богишамол 223, Юнусабадский район, Ташкент, 100140</p></bio><bio xml:lang="en"><p>Ph.D., Head of the Department of Neurology, Pediatric Neurology and Medical Genetics TashPMI, professor, vice-chairman of the Association of Neurologists of Uzbekistan,</p><p>ul. Bogishamol, 223, Yunusabadskii raion, Tashkent, 100140</p></bio><email xlink:type="simple">madjidova1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ташкентский Педиатрический медицинский институт</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Tashkent Pediatric Medical Institute</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>11</day><month>03</month><year>2017</year></pub-date><volume>8</volume><issue>4</issue><fpage>34</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Khalilova A.E., Madjidova Y.N., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Халилова А.Э., Маджидова Ё.Н.</copyright-holder><copyright-holder xml:lang="en">Khalilova A.E., Madjidova Y.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/315">https://www.epilepsia.su/jour/article/view/315</self-uri><abstract><p>Often, stroke, regardless of their type, are complicated by epileptic seizures, in different periods of the disease – both in the acute period, and in the late period of the disease.</p><p>Objective – to identify the characteristics of symptomatic epilepsy, occurred against the backdrop of stroke in children.</p><sec><title>Materials and Methods</title><p>Materials and Methods. The study involved 94 children aged from 3 months to 18 years with the effects of stroke and 21 children with acute stroke. A brain MRI, routine EEG, clinical tests.</p></sec><sec><title>Results</title><p>Results. Among infants prevailed hemorrhagic stroke, in most cases due to the DIC syndrome. Among older children, prevailed children with ischemic stroke, the most common cause of which were congenital and acquired heart defects. In 80.9% of cases were noted early seizures in the acute phase of stroke, more common in children with hemorrhagic stroke. In the acute phase of the disease seizures were mostly secondary generalized to partial component (68; 73.1%). On brain MRI in patients with ischemic stroke lesions localized cortical and subcortical. Late seizures were observed in 48 (41.7%) patients in the MRI of the brain of these patients had cystic atrophic changes in the brain in patients with primary generalized seizures subcortical structures of the brain were involved in the process.</p></sec><sec><title>Conclusions</title><p>Conclusions. Hemorrhagic strokes are more common in children under 1 year of age in subsequent periods prevalent ischemic strokes and nature of seizures depends on the location and massive fireplace.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Зачастую инсульты, вне зависимости от их типа, осложняются эпилептическими припадками, в различных периодах заболевания – как в остром, так и в отдаленном.</p><p>Цель исследования – выявить особенности симптоматической эпилепсии, возникшей на фоне острого нарушения мозгового кровообращения (ОНМК) у детей.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Обследовано 94 детей в возрасте от 3 месяцев до 18 лет с последствиями ОНМК и 21 ребенок с острыми инсультами. Проведено МРТ головного мозга, рутинная ЭЭГ, общеклинические исследования.</p></sec><sec><title>Результаты</title><p>Результаты. Среди детей грудного возраста превалировал геморрагический инсульт, в большинстве случаев обусловленный ДВС-синдромом. Среди детей постарше превалировали пациенты с ишемическим инсультом, самой частой причиной которых стали врожденные и приобретенные пороки сердца. В 80,9% случаях отмечались ранние эпилептические припадки в остром периоде инсультов, чаще у детей с геморрагическим инсультом. В остром периоде заболевания эпилептические припадки преимущественно носили вторично-генерализованный характер с парциальным компонентом (68; 73,1%). На МРТ головного мозга у больных с ишемическим инсультом очаги локализовались кортикально и субкортикально. Поздние эпилептические припадки отмечались у 48 (41,7%) больных, на МРТ головного мозга у этих больных отмечались кистозно-атрофические изменения головного мозга, у больных с первично-генерализованными эпилептическими припадками в процесс были вовлечены подкорковые образования головного мозга.</p></sec><sec><title>Заключение</title><p>Заключение. Геморрагические инсульты чаще встречаются у детей до 1 года, в последующих возрастных периодах превалируют ишемические инсульты и характер эпилептических припадков зависит от локализации и массивности очага.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>геморрагический инсульт</kwd><kwd>ишемический инсульт</kwd><kwd>постинсультная эпилепсия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hemorrhagic stroke</kwd><kwd>ischemic stroke</kwd><kwd>post-stroke epilepsy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бурд Г.С., Гехт А.Б., Лебедева А.В. и соавт. Эпилепсия у больных ишемической болезнью головного мозга. Журн. неврол. и психиатрии. 1998; 2: 4-8.</mixed-citation><mixed-citation xml:lang="en">Burd G.S., Geht A.B., Lebedeva A.V. i soavt. Zhurn. nevrol. i psihiatrii. 1998; 2: 4-8.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гехт А.Б., Лебедева А.В., Полетаев А.Б. и соавт. Постинсультная эпилепсия. Инсульт. 2003; 9: 195.</mixed-citation><mixed-citation xml:lang="en">Geht A.B., Lebedeva A.V., Poletaev A.B. i soavt. Insul’t. 2003; 9: 195.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Покровский А.В., Шубин А.А. Расслоение артерий (обзор литературы и клинические наблюдения). Ангиология и сосудистая хирургия. 2005; 12: 4: 27-38.</mixed-citation><mixed-citation xml:lang="en">Pokrovskij A.V., Shubin A.A. Angiologija i sosudistaja hirurgija. 2005; 12: 4: 27-38.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Прохорова Э.С. Эпилептические припадки при нарушениях мозгового кровообращения у больных ишемической болезнью и атеросклерозом: Автореф. Дис. …докт. мед. наук. М. 1981; 42.</mixed-citation><mixed-citation xml:lang="en">Prokhorova E.S. Epileptic seizures in violation of cerebral circulation in patients with coronary artery disease and atherosclerosis [Epilepticheskie pripadki pri narusheniyakh mozgovogo krovoobrashcheniya u bol’nykh ishemicheskoi bolezn’yu i aterosklerozom: Avtoref. dis… dokt. med. Nauk (in Russian)]. Moscow. 1981; 42.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Школьникова М.А., Абдулатипова И.В. Основные тенденции заболеваний и смертности от сердечно-сосудистых заболеваний детей и подростков в Российской Федерации. Рос. вестник перинатологии и педиатрии. 2008; 4: 4-10.</mixed-citation><mixed-citation xml:lang="en">Shkol’nikova M.A., Abdulatipova I.V. Ros. vestnik perinatologii i pediatrii. 2008; 4: 4-10.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Barolin G.S., Sherzer E. Epilleptische Anafalle bei Apoplektikern. Wein Narvenh. 1962; 20: 35-47.</mixed-citation><mixed-citation xml:lang="en">Barolin G.S., Sherzer E. Epilleptische Anafalle bei Apoplektikern. Wein Narvenh. 1962; 20: 35-47.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Camilo O., Golgstein L.B. Seizures and epilepsy after ischemic stroke. Stroke. 2004; 35 (7): 1769-1775.</mixed-citation><mixed-citation xml:lang="en">Camilo O., Golgstein L.B. Seizures and epilepsy after ischemic stroke. Stroke. 2004; 35 (7): 1769-1775.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Carvalho K.S., Garg B.P. Arterial stroke in children. Neurol. Clin. 2002; 20: 1079-10100.</mixed-citation><mixed-citation xml:lang="en">Carvalho K.S., Garg B.P. Arterial stroke in children. Neurol. Clin. 2002; 20: 1079-10100.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gabis L.V., Yangola R., Lenn N. J. Time lag to diagnosis of stroke in children. Pediatrics. 2002; 110: 924-928.</mixed-citation><mixed-citation xml:lang="en">Gabis L.V., Yangola R., Lenn N. J. Time lag to diagnosis of stroke in children. Pediatrics. 2002; 110: 924-928.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ganesan V., Chong W.K., Cox T.C. et al. Posterior circulation stroke in childhood: risk factors and recurrence. Neurology. 2002; 9: 1552-1556.</mixed-citation><mixed-citation xml:lang="en">Ganesan V., Chong W.K., Cox T.C. et al. Posterior circulation stroke in childhood: risk factors and recurrence. Neurology. 2002; 9: 1552-1556.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Fullerton H. J., Johnston S.C., Smith W.S. Arterial dissection and stroke in children. Neurology. 2001; 57: 7 (October): 96-111.</mixed-citation><mixed-citation xml:lang="en">Fullerton H. J., Johnston S.C., Smith W.S. Arterial dissection and stroke in children. Neurology. 2001; 57: 7 (October): 96-111.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lamy C., Domigo V., Semah F. et al. Early and late seizures after cryptogenic ischemic stroke in young adults. Neurology. 2003; 60 (3): 365-366.</mixed-citation><mixed-citation xml:lang="en">Lamy C., Domigo V., Semah F. et al. Early and late seizures after cryptogenic ischemic stroke in young adults. Neurology. 2003; 60 (3): 365-366.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lancman M. E., Golimstok A., Norscini J. et al. Risk factors for developing seizures after stroke. Epilepsia. 1993; 34: 141-3.</mixed-citation><mixed-citation xml:lang="en">Lancman M. E., Golimstok A., Norscini J. et al. Risk factors for developing seizures after stroke. Epilepsia. 1993; 34: 141-3.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lossius M. I., Ronning O.M., Slapo G.D. et al. Poststroke epilepsy: occurrence and predictors-a long-term prospective controlled study Akershus Stroke Study. Epilepsia. 2005; 46 (8): 1246-1251.</mixed-citation><mixed-citation xml:lang="en">Lossius M. I., Ronning O.M., Slapo G.D. et al. Poststroke epilepsy: occurrence and predictors-a long-term prospective controlled study Akershus Stroke Study. Epilepsia. 2005; 46 (8): 1246-1251.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ramsay R. E., Rowan A. J., Pryor F.M. Special considerations in treating the elderly patient with epilepsy. Neurology. 2004; 62: 24-29.</mixed-citation><mixed-citation xml:lang="en">Ramsay R. E., Rowan A. J., Pryor F.M. Special considerations in treating the elderly patient with epilepsy. Neurology. 2004; 62: 24-29.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Roach E.S. Etiology of stroke in children. Semin. Radial. Neurol. 2000; 7: 244-260.</mixed-citation><mixed-citation xml:lang="en">Roach E.S. Etiology of stroke in children. Semin. Radial. Neurol. 2000; 7: 244-260.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Rumbach L., Sablot D., Berger E. et al. Status Epilepticus in stroke: report on a hospital-based stroke cohort. Neurology. 2000; 54 (2): 350-354.</mixed-citation><mixed-citation xml:lang="en">Rumbach L., Sablot D., Berger E. et al. Status Epilepticus in stroke: report on a hospital-based stroke cohort. Neurology. 2000; 54 (2): 350-354.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
