epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333.2016.8.4.058-066epilepsia-318Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИEPILEPSY SYNDROMES WITH CONTINIUOS SPIKE AND WAVE ACTIVITY DURING SLEEPЭПИЛЕПТИЧЕСКИЕ СИНДРОМЫ С ПРОДОЛЖЕННОЙ СПАЙК-ВОЛНОВОЙ АКТИВНОСТЬЮ ВО СНЕШидловскаяО. А.ShidlovskayaO. A.

аспирант кафедры неврологии, нейрохирургии и медицинской генетики,

невролог Научно-исследовательского клинического института педиатрии,

ул. Островитянова, д. 1, Москва, 117997

postgraduates of the department Nevrology, Neurosurgery and Medical Genetics,

Neurologist of the Research Clinical Institute of Pediatrics,

ul. Ostrovityanova, 1, Moscow, 117997

shidlovsckaya.oa@yandex.ruБелоусоваЕ. Д.BelousovaE. D.

д.м.н., профессор, Заслуженный врач Российской Федерации, заведующая отделом психоневрологии и эпилептологии Научно-исследовательского клинического института педиатрии,

ул. Островитянова, д. 1, Москва, 117997 

MD, Professor, Honored Doctor of the Russian Federation, Department psychoneurology Epileptology and Research Clinical Institute,

ul. Ostrovityanova, 1, Moscow, 117997

ebelousova@inbox.ruФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава РоссииРоссияFSBE HEN. I. Pirogov RNRMU MOH RussiaRussian Federation201612032017845866Copyright © Shidlovskaya O.A., Belousova E.D., 20172017Шидловская О.А., Белоусова Е.Д.Shidlovskaya O.A., Belousova E.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/318

Syndromes with continuous spikes and waves during sleep (CSWS) are being actively studied now. Etiological factors include both genetic causes and structural brain disorders; frequently – the damage of the thalamus, and congenital malformations. In most cases, the persistence of CSWS pattern leads to a neurocognitive dysfunction. Two mechanisms of the intellectual regression are supposed: a violation of brain maturation processes and the effect of the remote inhibition. The most effective treatment is considered to be a combination of hormones and antiepileptic drugs. It is often possible to restore a normal level of child development in case of the early diagnosis and rational therapeutic tactics. However, if more than 18 months has passed since the onset of seizures, as a rule, intellectual functions can’t be improved.

В настоящий момент синдромы с продолженной спайк-волновой активностью во сне (CSWS) активно изучаются во всем мире. Этиология синдромов может быть как генетической, так и связанной со структурными поражениями головного мозга (особенно таламуса) и пороками развития коры. В большинстве случаев персистирование паттерна продолженной спайк-волновой активности во сне приводит к нейрокогнитивной дисфункции. Рассматриваются два механизма интеллектуального регресса: нарушение процессов созревания мозга и эффект «дистанционного торможения». Наиболее эффективным методом лечения считается сочетание гормональной терапии с антиэпилептическими препаратами. При своевременной диагностике и рациональной терапевтической тактике возможно восстановление нормального уровня развития ребенка. Но если с момента дебюта приступов прошло более 18 месяцев, как правило, улучшить интеллектуальные функции не удается.

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The authors declare that there are no conflicts of interest present.