epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333.2016.8.4.074-083epilepsia-320Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИNONCONVULSIVE STATUS EPILEPTICUS IN PATIENTS WITH LIMBIC ENCEPHALITISБЕССУДОРОЖНЫЙ ЭПИЛЕПТИЧЕСКИЙ СТАТУС ПРИ ЛИМБИЧЕСКОМ ЭНЦЕФАЛИТЕШерманМ. А.ShermanM. A.

д.м.н., куратор неврологической службы клиники,

ул. Карла Маркса, 112, г. Киров, 610027

PhD, the curator of the neurological clinic service,

ul. Karla Marksa, 112, Kirov, 610027

sherman@list.ruАрдашевИ. В.ArdashevI. V.

врач, неврологическое отделение,

ул. Ивана Попова, 41, г. Киров, 610014

physician, neurology department,

ul. Popova, 41, Kirov, 610014

ardnokgb1@rambler.ruПономареваИ. В.PonomarevaI. V.

к.м.н., заведующая неврологической службой

просп. Победы, 376в, г. Челябинск, 354000

PhD, head of the Department of neurology,

prosp. Pobedy, 376v, Chelyabinsk, 354000

irina_victorovna@mail.ruШерманХ.ShermanH.

врач, отделение ортопедии,

Медицинский Факультет им. Саклера, 

ул. Вейцмана, 6, Тель-Авив, 642396

MD, physician at Orthopedic Department,

affiliated to Sackler School of Medicine,

6 Weizmann St., Tel-Aviv, 642396

sheralmi@gmail.comФГБОУ ВО «Кировский государственный медицинский университет» Минздрава РоссииРоссияKirov State Medical UniversityRussian FederationКОГБУЗ «Кировская городская клиническая больница №1»РоссияKirov City Clinical Hospital №1Russian FederationГБУЗ «Областная клиническая больница №4»РоссияRegional Clinical Hospital №4Russian FederationМедицинский центр им. Сораски, Тель-Авивский УниверситетИзраильSourasky Medical Center, Tel-Aviv UniversityIsrael201612032017847483Copyright © Sherman M.A., Ardashev I.V., Ponomareva I.V., Sherman H., 20172017Шерман М.А., Ардашев И.В., Пономарева И.В., Шерман Х.Sherman M.A., Ardashev I.V., Ponomareva I.V., Sherman H.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/320

Limbic encephalitis (LE) may be manifested by non-convulsive status epilepticus (NCSE). Two clinical cases of LE presenting with NCSE, one of them with a background ovarian theratoma, and the value of electroencephalographic triphasic and delta-beta waves in diagnosis of LE, are discussed in this paper. Course of glucocorticoid pulse-therapy, complimented by long-term regiment of valproic acid, is shown as a successful treatment modality for LE with NCSV.

Бессудорожный эпилептический статус (БЭС) рассмотрен в качестве одного из вариантов манифестации лимбического энцефалита (ЛЭ), оценено значение в диагностике БЭС таких электроэнцефалографических паттернов, как трехфазные волны и бета-дельта щетки. Представлены клинические случаи ЛЭ, при которых БЭС занимал ведущее место в клинике заболевания, один из них – ассоциированный с тератомой яичников. Описан вариант успешной терапии лимбического симптомокомплекса в сочетании с БЭС комбинацией глюкокортикостероидной пульс-терапии и длительного применения вальпроевой кислоты.

лимбический энцефалитпаранеопластическийаутоиммунныйиммуномедиаторные расстройства центральной нервной системы (ЦНС)бессудорожный эпилептический статустрехфазные волныбета-дельта щеткииммуно-супрессивная терапиявальпроевая кислотаlimbic encephalitisparaneoplasticautoimmuneimmune-mediated central nervous system disordersnon-convulsive status epilepticustriphasic wavesbeta-delta wavesimmunosuppressive therapyvalproic acidReferencesКарлов В.А. Эпилептический статус бессудорожных припадков. Журнал неврологии и психиатрии им. С.С. Корсакова. 2008; 5: 92-98.Karlov V.A. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2008; 5: 92-98.Лебедева А.В., Хомутов В. Е., Ершов А.В., Гузь Д.В. Неконвульсивные приступы и неконвульсивный эпилептический статус. Новые возможности терапии. Эпилепсия и пароксизмальные состояния. 2012; 4(2): 28-33.Lebedeva A.V., Khomutov V. E., Ershov A.V., Guz’ D.V. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions. 2012; 4(2): 28-33.Ahmad A., Ramakrishna S., Meara J., Doran M. Autoimmune limbic encephalitis: a reversible form of rapidly progressive amnesia and seizures. J R Coll Physicians Edinb. 2010; 40: 123-5.Ahmad A., Ramakrishna S., Meara J., Doran M. Autoimmune limbic encephalitis: a reversible form of rapidly progressive amnesia and seizures. J R Coll Physicians Edinb. 2010; 40: 123-5.Anderson N. E., Barber P.A. Limbic encephalitis – a review. J Clin Neurosci. 2008; 15 (9): 961-71.Anderson N. E., Barber P.A. Limbic encephalitis – a review. J Clin Neurosci. 2008; 15 (9): 961-71.Andrade D.M., Tai P., Dalmau J., Wennberg R. Tonic seizures: a diagnostic clue of anti-LGI1 encephalitis. Neurology. 2011 Apr 12; 76 (15): 1355-7.Andrade D.M., Tai P., Dalmau J., Wennberg R. Tonic seizures: a diagnostic clue of anti-LGI1 encephalitis. Neurology. 2011 Apr 12; 76 (15): 1355-7.Armangue T., Petit-Pedrol M., Dalmau J. Autoimmune Encephalitis in Children. J Child Neurol. 2012; 27: 1460-1469.Armangue T., Petit-Pedrol M., Dalmau J. Autoimmune Encephalitis in Children. J Child Neurol. 2012; 27: 1460-1469.Bataller L., Galiano R., Garcia-Escrig M. et al. Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptor. Neurology. 2010; 74: 265-7.Bataller L., Galiano R., Garcia-Escrig M. et al. Reversible paraneoplastic limbic encephalitis associated with antibodies to the AMPA receptor. Neurology. 2010; 74: 265-7.Boronat A., Sabater L., Saiz A., Dalmau J., Graus F. GABA(B) receptor antibodies in limbic encephalitis and anti-GAD associated neurological disorders. Neurology. 2011; 76 (9): 795-800.Boronat A., Sabater L., Saiz A., Dalmau J., Graus F. GABA(B) receptor antibodies in limbic encephalitis and anti-GAD associated neurological disorders. Neurology. 2011; 76 (9): 795-800.Breese E.H., Dalmau J., Lennon V.A., Apiwattanakul M., Sokol D.K. Anti-Nmethyl-D-aspartate receptor encephalitis: early treatment is beneficial. Pediatr Neurol. 2010; 42: 213-4.Breese E.H., Dalmau J., Lennon V.A., Apiwattanakul M., Sokol D.K. Anti-Nmethyl-D-aspartate receptor encephalitis: early treatment is beneficial. Pediatr Neurol. 2010; 42: 213-4.Breese E.H., Dalmau J., Lennon V.A., Apiwattanakul M., Sokol D.K. Anti-Nmethyl-D-aspartate receptor encephalitis: early treatment is beneficial. Pediatr Neurol. 2010; 42: 213-4.Breese E.H., Dalmau J., Lennon V.A., Apiwattanakul M., Sokol D.K. Anti-Nmethyl-D- aspartate receptor encephalitis: early treatment is beneficial. Pediatr Neurol. 2010; 42: 213-4.Buckley C., Oger J., Clover L. et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann. Neurol. 2001; 50: 73-8.Buckley C., Oger J., Clover L. et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann. Neurol. 2001; 50: 73-8.Chandra S.R., Seshadri R., Chikabasaviah Y., Issac T.G. Progressive limbic encephalopathy: Problems and prospects. Ann Indian Acad Neurol. 2014; 17 (2): 166-170.Chandra S.R., Seshadri R., Chikabasaviah Y., Issac T.G. Progressive limbic encephalopathy: Problems and prospects. Ann Indian Acad Neurol. 2014; 17 (2): 166-170.Dalmau J., Gleichman A. J., Hughes E.G. et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008; 7: 1091-98.Dalmau J., Gleichman A. J., Hughes E.G. et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008; 7: 1091-98.Dalmau J., Lancaster E., MartinezHernandez E., Rosenfeld M.R., BaliceGordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. Jan 2011; 10 (1): 63-74.Dalmau J., Lancaster E., MartinezHernandez E., Rosenfeld M.R., BaliceGordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. Jan 2011; 10 (1): 63-74.Dalmau J., Tüzün E., Wu H.Y. et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007; 61: 25-36.Dalmau J., Tüzün E., Wu H.Y. et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007; 61: 25-36.Dalmau J., Graus F., Villarejo A. et al. Clinical analysis of anti-Ma2-associated encephalitis. Brain. 2004; 127: 1831-44.Dalmau J., Graus F., Villarejo A. et al. Clinical analysis of anti-Ma2-associated encephalitis. Brain. 2004; 127: 1831-44.Granerod J., Ambrose H. E., Davies N.W. et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010 Dec; 10 (12): 835-44.Granerod J., Ambrose H. E., Davies N.W. et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010 Dec; 10 (12): 835-44.Gu W., Brodtkorb E., Steinlein O.K. LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. Ann Neurol. 2002; 52: 364-7.Gu W., Brodtkorb E., Steinlein O.K. LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. Ann Neurol. 2002; 52: 364-7.Guletkin H.S., Rosenfeld M.R., Voltz R., Eichen J., Posner J., Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunologic findings and tumor association in 50 patients. Brain. 2000; 123: 1481-1494.Guletkin H.S., Rosenfeld M.R., Voltz R., Eichen J., Posner J., Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunologic findings and tumor association in 50 patients. Brain. 2000; 123: 1481-1494.Hainsworth J.B., Shishido A., Theeler B. J., Carroll C.G., Fasano R. E. Treatment responsive GABA(B)-receptor limbic encephalitis presenting as new-onset superrefractory status epilepticus (NORSE) in a deployed U.S. soldier. Epileptic Disord. 2014; 16 (4): 486-93.Hainsworth J.B., Shishido A., Theeler B. J., Carroll C.G., Fasano R. E. Treatment responsive GABA(B)-receptor limbic encephalitis presenting as new-onset superrefractory status epilepticus (NORSE) in a deployed U.S. soldier. Epileptic Disord. 2014; 16 (4): 486-93.Henry C., Husson H., de Broucker T. Autoimmune limbic encephalitis with antiNMDA receptor antibodies and ovarian teratoma: a treatable form of paraneoplastic limbic encephalitis. Rev Neurol. 2009; 165 (1): 70-5.Henry C., Husson H., de Broucker T. Autoimmune limbic encephalitis with antiNMDA receptor antibodies and ovarian teratoma: a treatable form of paraneoplastic limbic encephalitis. Rev Neurol. 2009; 165 (1): 70-5.Hurley K., Herron M., McDermott S., Farrell T., O’Riordan D. Squamous Cell Lung Carcinoma Presenting With Refractory Status Epilepticus: A Case Report of Paraneoplastic Limbic Encephalitis. Respir Care. 2015 Aug; 60 (8): e144-7.Hurley K., Herron M., McDermott S., Farrell T., O’Riordan D. Squamous Cell Lung Carcinoma Presenting With Refractory Status Epilepticus: A Case Report of Paraneoplastic Limbic Encephalitis. Respir Care. 2015 Aug; 60 (8): e144-7.Ide Т., Iizuka Т., Suzuki N. Limbic encephalitis associated with autoimmune diseases. Neurol Med. 2003; 59: 31-37.Ide T., Iizuka T., Suzuki N. Limbic encephalitis associated with autoimmune diseases. Neurol Med. 2003; 59: 31-37.Iizuka T., Sakai F., Ide T. et al. Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal. Neurology. 2008; 70: 504-11.Iizuka T., Sakai F., Ide T. et al. Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal. Neurology. 2008; 70: 504-11.Ishiura H., Matsuda S., Higashihara M. et al. Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology.2008; 71: 1921-23.Ishiura H., Matsuda S., Higashihara M. et al. Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology.2008; 71: 1921-23.Janati A.B., AlGhasab N., Umair M. Focal triphasic sharp waves and spikes in the electroencephalogram. Neurol Sci. 2015 Feb; 36 (2): 221-6.Janati A.B., AlGhasab N., Umair M. Focal triphasic sharp waves and spikes in the electroencephalogram. Neurol Sci. 2015 Feb; 36 (2): 221-6.Johnson N., Henry J.C., Fessler A. J., Dalmau J. Prolonged non-convulsive status epilepticus in anti-NMDAR encephalitis with ovarian teratoma. Neurology. 2010; 75: 1480-82.Johnson N., Henry J.C., Fessler A. J., Dalmau J. Prolonged non-convulsive status epilepticus in anti-NMDAR encephalitis with ovarian teratoma. Neurology. 2010; 75: 1480-82.Kaplan P.W., Sutter R. Affair With Triphasic Waves-Their Striking Presence, Mysterious Significance, and Cryptic Origins: What are They? J Clin Neurophysiol. 2015 Oct. 32 (5): 401-5.Kaplan P.W., Sutter R. Affair With Triphasic Waves-Their Striking Presence, Mysterious Significance, and Cryptic Origins: What are They? J Clin Neurophysiol. 2015 Oct. 32 (5): 401-5.Kaplan P.W., Rossetti A.O., Kaplan E.H., Wieser H.G. Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. Epilepsy Behav. 2012 May; 24 (1): 1-6.Kaplan P.W., Rossetti A.O., Kaplan E.H., Wieser H.G. Proposition: limbic encephalitis may represent limbic status epilepticus. A review of clinical and EEG characteristics. Epilepsy Behav. 2012 May; 24 (1): 1-6.Kaya D., Bingol C.A. Significance of atypical triphasic waves for diagnosing nonconvulsive status epilepticus. Epilepsy Behav. 2007 Dec; 11 (4): 567-77.Kaya D., Bingol C.A. Significance of atypical triphasic waves for diagnosing nonconvulsive status epilepticus. Epilepsy Behav. 2007 Dec; 11 (4): 567-77.Kirkpatrick McNeill P., Clarke C.D., Sonmezturk H.H., Abou-Khalil B. Rhythmic delta activity represents a form of nonconvulsive status epilepticus in antiNMDA receptor antibody encephalitis. Epilepsy Behav. 2011 Feb; 20 (2): 392-4.Kirkpatrick McNeill P., Clarke C.D., Sonmezturk H.H., Abou-Khalil B. Rhythmic delta activity represents a form of nonconvulsive status epilepticus in antiNMDA receptor antibody encephalitis. Epilepsy Behav. 2011 Feb; 20 (2): 392-4.Lai M, Hughes EG, Peng X et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009; 65: 424-34.Lai M, Hughes EG, Peng X et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009; 65: 424-34.Lai M., Huijbers M.G., Lancaster E. et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol. 2010; 9: 776-85.Lai M., Huijbers M.G., Lancaster E. et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol. 2010; 9: 776-85.Lancaster E., Lai M., Peng X. et al. Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol. 2010; 9: 67-76.Lancaster E., Lai M., Peng X. et al. Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol. 2010; 9: 67-76.Lawn N.D., Westmoreland B.F., Kiely M.J., Lennon V.A., Vernino S. Clinical, magnetic resonance imaging, and electroencephalographic findings in paraneoplastic limbic encephalitis. Mayo Clinic Proceedings, 2003; 78 (11): 1363-1368.Lawn N.D., Westmoreland B. F., Kiely M. J., Lennon V.A., Vernino S. Clinical, magnetic resonance imaging, and electroencephalographic findings in paraneoplastic limbic encephalitis. Mayo Clinic Proceedings. 2003; 78 (11): 1363-1368.Momoo T., Johkura K., Kuroiwa Y. Spikewave stupor in a patient with metabolic disorder. J Clin Neurosci. 2006 Feb; 13 (2): 301-3.Momoo T., Johkura K., Kuroiwa Y. Spikewave stupor in a patient with metabolic disorder. J Clin Neurosci. 2006 Feb; 13 (2): 301-3.Mundiyanapurath S., Jarius S., Probst C., Stöcker W., Wildemann B., Bösel J. GABAB-receptor antibodies in paraneoplastic brainstem encephalitis. J Neuroimmunol. 2013; 259 (1-2): 88-91.Mundiyanapurath S., Jarius S., Probst C., Stöcker W., Wildemann B., Bösel J. GABAB- receptor antibodies in paraneoplastic brainstem encephalitis. J Neuroimmunol. 2013; 259 (1-2): 88-91.Mut M., Schiff D., Dalmau J. Paraneoplastic recurrent multifocal encephalitis presenting with epilepsia partialis continua. J Neurooncol. 2005 Mar; 72 (1): 63-6.Mut M., Schiff D., Dalmau J. Paraneoplastic recurrent multifocal encephalitis presenting with epilepsia partialis continua. J Neurooncol. 2005 Mar; 72 (1): 63-6.Nokura K., Yamamoto H., Okawara Y., Koga H., Osawa H., Sakai K. Reversible limbic encephalitis caused by ovarian teratoma. Acta Neurol Scand. 1997; 95: 367-73.Nokura K., Yamamoto H., Okawara Y., Koga H., Osawa H., Sakai K. Reversible limbic encephalitis caused by ovarian teratoma. Acta Neurol Scand. 1997; 95: 367-73.Okamura H., Oomori N., Uchitomi Y. An acutely confused 15-year-old girl. Lancet. 1997; 350: 488.Okamura H., Oomori N., Uchitomi Y. An acutely confused 15-year-old girl. Lancet. 1997; 350: 488.Pranzatelli M.R. Paraneoplastic Syndromes: An Unsolved Murder. Seminars in Pediatric Neurology. 2000; 7 (2): 118-130.Pranzatelli M.R. Paraneoplastic Syndromes: An Unsolved Murder. Seminars in Pediatric Neurology. 2000; 7 (2): 118-130.Pruss H., Dalmau J., Arolt V., Wandinger K.P. Anti-NMDA-receptor encephalitis. An interdisciplinary clinical picture. Nervenarzt. 2010 Apr; 81 (4): 396, 398, 400, passim.Pruss H., Dalmau J., Arolt V., Wandinger K.P. Anti-NMDA-receptor encephalitis. An interdisciplinary clinical picture. Nervenarzt. 2010 Apr; 81 (4): 396, 398, 400, passim.Rosenfeld M.R., Dalmau J. Anti-NMDAReceptor Encephalitis and Other Synaptic Autoimmune Disorders. Curr Treat Options Neurol. Jun 2011; 13 (3): 324-332.Rosenfeld M.R., Dalmau J. Anti-NMDAReceptor Encephalitis and Other Synaptic Autoimmune Disorders. Curr Treat Options Neurol. Jun 2011; 13 (3): 324-332.Sabin T.D., Jednacz J.A., Staats P.N. Case records of the Massachusetts General Hospital. Case 26-2008. A 26-year-old woman with headache and behavioral changes. N Engl J Med. 2008; 359: 842-53.Sabin T.D., Jednacz J.A., Staats P.N. Case records of the Massachusetts General Hospital. Case 26-2008. A 26-year-old woman with headache and behavioral changes. N Engl J Med. 2008; 359: 842-53.Sarosh R., Alexander S., Waters P. et al. Antibodies to Kv1 potassium channelcomplex proteins leucine-rich, glioma inactivated 1 protein and contactinassociated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain. 2010; 133: 2734-48.Sarosh R., Alexander S., Waters P. et al. Antibodies to Kv1 potassium channelcomplex proteins leucine-rich, glioma inactivated 1 protein and contactinassociated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain. 2010; 133: 2734-48.Schmiedeskamp M., Cariga P., Ranta A. Anti-NMDA-receptor autoimmune encephalitis without neoplasm: a rare condition. NZMJ. 2010; 123 (1322): 67-68.Schmiedeskamp M., Cariga P., Ranta A. Anti-NMDA-receptor autoimmune encephalitis without neoplasm: a rare condition. NZMJ. 2010; 123 (1322): 67-68.Serban-Pereteanu A.S., Trasca D., Stefanescu V.C., Bustan M., Zurac S., Cojocaru I.M. Anti-NMDA-receptor encephalitis in a young women: a diagnostic challenge. RJN. 2014; XIII (4): 200-211.Serban-Pereteanu A.S., Trasca D., Stefanescu V.C., Bustan M., Zurac S., Cojocaru I.M. Anti-NMDA-receptor encephalitis in a young women: a diagnostic challenge. RJN. 2014; XIII (4): 200-211.Sethi N.K., Kim K.W., Sethi P.K. EEG and PET changes in Anti-Nmethyl-D-aspartic acid receptor encephalitis. Am J Psychiatry. 2014; 171 (8): 889-90.Sethi N.K., Kim K.W., Sethi P.K. EEG and PET changes in Anti-Nmethyl-D-aspartic acid receptor encephalitis. Am J Psychiatry. 2014; 171 (8): 889-90.Shoji H., Asaoka K., Ayabe M., Ichiyama T., Sakai K. Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis? Intern Med. 2004 Apr; 43 (4): 348.Shoji H., Asaoka K., Ayabe M., Ichiyama T., Sakai K. Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis? Intern Med. 2004 Apr; 43 (4): 348.Sonkaya A.R., Şenol M.G., Demir S., Kendirli M. T., Sivrioğlu A.K., Haholu H.M., Özdağ F. Limbic encephalitis association with tuberculosis: A case report. Dis Mol Med. 2014; 2: 73-76.Sonkaya A.R., Şenol M.G., Demir S., Kendirli M. T., Sivrioğlu A.K., Haholu H.M., Özdağ F. Limbic encephalitis association with tuberculosis: A case report. Dis Mol Med. 2014; 2: 73-76.Vedeler C.A., Storstein A. Autoimmune limbic encephalitis. Acta Neurol Scand. Suppl. 2009; (189): 63-7.Vedeler C.A., Storstein A. Autoimmune limbic encephalitis. Acta Neurol Scand. Suppl. 2009; (189): 63-7.Vitaliani R., Mason W., Ances B. et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005; 58: 594-604.Vitaliani R., Mason W., Ances B. et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005; 58: 594-604.Vitaliani R., Mason W., Ances B. et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005; 58: 594-604.Vitaliani R., Mason W., Ances B. et al. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005; 58: 594-604.Wingfield T., McHugh C., Vas A., Richardson A., Wilkins E., Bonington A., Varma A. Autoimmune encephalitis: a case series and comprehensive review of literature. Q J Med. 2011; 104: 921-931.Wingfield T., McHugh C., Vas A., Richardson A., Wilkins E., Bonington A., Varma A. Autoimmune encephalitis: a case series and comprehensive review of literature. Q J Med. 2011; 104: 921-931.Wong-Kisiel L.C., Ji T., Renaud D. L. et al. Response to immunotherapy in a 20-monthold boy with anti-NMDA receptor encephalitis. Neurology. 2010; 74: 1550-51.Wong-Kisiel L.C., Ji T., Renaud D. L. et al. Response to immunotherapy in a 20-monthold boy with anti-NMDA receptor encephalitis. Neurology. 2010; 74: 1550-51.Young G.B., Jordan K.G., Doig G.S. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology. 1996; 47: 83-89.Young G.B., Jordan K.G., Doig G.S. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology. 1996; 47: 83-89.Zhang J., Xanthopoulos P., Liu Chang-Chia, Bearden S., Uthman D.V., Pardalos P.M. Real-time differentiation of nonconvulsive status epilepticus from other encephalopathies using quantitative EEG analysis: A pilot study. Epilepsia. 2010; 51 (2): 243-250.Zhang J., Xanthopoulos P., Liu Chang-Chia, Bearden S., Uthman D.V., Pardalos P.M. Real-time differentiation of nonconvulsive status epilepticus from other encephalopathies using quantitative EEG analysis: A pilot study. Epilepsia. 2010; 51 (2): 243-250.

The authors declare that there are no conflicts of interest present.