epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333.2016.8.4.091-098epilepsia-322Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИTHE DIAGNOSTIC VALUE OF EEG AND BIOCHEMICAL MARKERS OF BRAIN INJURY IN HYPOXIC-ISCHEMIC ENCEPHALOPATHYДИАГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ ЭЭГ И БИОХИМИЧЕСКИХ МАРКЕРОВ ПОВРЕЖДЕНИЯ МОЗГА ПРИ ГИПОКСИЧЕСКИ-ИШЕМИЧЕСКОЙ ЭНЦЕФАЛОПАТИИБлиновД. В.BlinovD. V.

к.м.н.,

ул. Островитянова, д. 1, Москва, 117997

MD, PhD,

ul. Ostrovitianova, 1, Moscow, 117997

blinov2010@gmail.comФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава РоссииРоссияFSBE HE N. I. Pirogov RNRMU MOH RussiaRussian Federation201612032017849198Copyright © Blinov D.V., 20172017Блинов Д.В.Blinov D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/322

Perinatal hypoxic-ischemic encephalopathy (HIE) is a one of common cause of damage to neonatal CNS. Electroencephalography (EEG) has diagnostic value for choice of therapeutic interventions and predicting of outcomes. Sarnat classification is used EEG findings. EEG-monitoring and amplitude-integrated EEG could be used in Intensive Care Unit to provide information about the prognosis for the infant. Comprehensive assessment based on EEG data and serum determination of biochemical markers of brain damage could be feasible for identifying risk of subsequent brain damage that might benefit for treatment and predict of outcomes after HIE. Further studies in this area are clearly needed.

Перинатальная гипоксически-ишемическая энцефалопатия (ГИЭ) является одной из основных причин повреждения ЦНС у новорожденных. Электроэнцефалография (ЭЭГ) имеет диагностическое значение для выбора терапии и определения прогноза заболевания. Данные ЭЭГ используются в классификации Сарната, являющейся наиболее используемой в мире для определения тяжести ГИЭ. В условиях отделения интенсивной терапии может использоваться ЭЭГ-мониторинг и амплитудно-интегрированная ЭЭГ, с помощью которых можно получить необходимую для построения прогноза информацию о состоянии ЦНС. Комплексную оценку, основанную на данных ЭЭГ и определении концентрации биохимических маркеров повреждения мозга в сыворотке крови, возможно применять для определения риска отсроченного поражения мозга, что может иметь пользу при выборе тактики лечения и прогнозирования исходов ГИЭ. Необходимы дальнейшие исследования в этом направлении.

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The authors declare that there are no conflicts of interest present.