epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLCepilepsia-33Research ArticleLITERATURE SURVEYОБЗОР ЛИТЕРАТУРЫZONEGRAN. NEW IN EVIDENTIAL PHARMACOTHERAPY OF EPILEPSY: OPPORTUNITIES AND EXPECTATIONSЗОНЕГРАН®. НОВОЕ В ДОКАЗАТЕЛЬНОЙ ФАРМАКОТЕРАПИИ ЭПИЛЕПСИИ: ВОЗМОЖНОСТИ И ОЖИДАНИЯРудаковаИ. Г.RudakovaI. G.Московский областной клинический научно-исследовательский институт имени М. Ф. ВладимирскогоРоссияMoscov regional scientific researth clinical institute names M.F. VladimirskiyRussian Federation201401062016616469Copyright © Rudakova I.G., 20162016Рудакова И.Г.Rudakova I.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/33

Abstract: this article represents review of literature devoted to a new antiepileptic drug Zonegran (zonisamide, ZNS). History of successful clinical use of ZNS in world practice lasts for 25 years. Zonisamide is on the Russian market from 2014 and is approved for monotherapy and adjunctive therapy of partial seizures with or without secondary generalization. This review is based on principles of evidence based medicine. Data of ZNS mechanism of action and pharmacokinetics are considered. Results of the most significant studies of ZNS efficacy and tolerability in drug-resistant focal epilepsy in adults and children in adjunctive and monotherapy regimes are presented. Possibilities of clinical use of ZNS in treatment of concomitant diseases are considered.

В статье представлен обзор литературы, посвященный новому антиэпилептическому препарату Зонегран® (зонисамид, ЗНС). История успешного применения ЗНС в мировой практике насчитывает 25 лет. В России препарат появился в 2014 г. и зарегистрирован для применения в режимах монотерапии и дополнительной терапии фокальных эпилептических приступов с вторичной генерализацией или без у взрослых. Обзор построен на основе принципов доказательной медицины. Рассматриваются данные о механизме действия и фармакокинетике ЗНС. Изложены результаты наиболее значимых исследований эффективности и переносимости ЗНС при фармакорезистентной парциальной эпилепсии у взрослых и детей при применении в режимах политерапии и монотерапии. Рассмотрены возможности применения ЗНС при лечении коморбидных состояний.

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The authors declare that there are no conflicts of interest present.