epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333.2017.9.1.051-061epilepsia-334Research ArticleSCIENTIFIC SURVEYSНАУЧНЫЕ ОБЗОРЫADVERSE EFFECTS OF ANTIEPILEPTIC DRUGSПОБОЧНЫЕ ЭФФЕКТЫ АНТИЭПИЛЕПТИЧЕСКОЙ ТЕРАПИИКовалеваИ. Ю.KovalevaI. Yu.

Ковалева Ирина Юрьевна – кандидат медицинских наук, профессор кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета.

Ул. Островитянова, д. 1, Москва, 117997, Тел.: +7(495)4343690

Kovaleva Irina Jur’evna – MD, PhD, Professor  in the Department of Neurology, Neurosurgery and Medical Genetics at Medical Faculty.

1 Ostrovityanova str., Moscow, 117997

irinakov@inbox.ruФГБОУ ВО «РНИМУ им. Н. И. Пирогова» Минздрава РоссииРоссияN. I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation201724052017915161Copyright © Kovaleva I.Y., 20172017Ковалева И.Ю.Kovaleva I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/334

Antiepileptic drugs are frequently associated with a risk of adverse effects,  which have an impact on the tolerability and success of treatment. Patients who develop intolerable adverse effects have to discontinue treatment early after initiation or to switch to another antiepileptic drug. A long-term management  strategy for the patients with such a long-lasting chronic disease  as epilepsy should include both effective  seizure control and early detection  of adverse drug events, ensuring prognosis, prevention and minimizing side effects,  which is quite important. All these measures  are expected to improve adherence to treatment, quality of patients’ life and control of epilepsy.

Зачастую использование антиэпилептических препаратов ассоциируется с риском развития нежелательных явлений,  непосредственно влияющих на переносимость и успех лечения  в целом.  Пациенты с выраженными нежелательными явлениями вынуждены преждевременно прекращать лечение  или менять лекарственный препарат. Долговременная стратегия ведения  пациентов с таким длительно текущим заболеванием, как эпилепсия, должна включать не только достижение контроля над приступами, но и максимально  раннее выявление нежелательных явлений, предупреждение, прогнозирование и минимизацию проявлений побочных  эффектов. Это позволит улучшить приверженность к лечению,  качество жизни пациентов и достигнуть контроля над эпилепсией.

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The authors declare that there are no conflicts of interest present.