epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333.2017.9.3.047-053epilepsia-356Research ArticleLITERATURE SURVEYОБЗОР ЛИТЕРАТУРЫDEPRESSIONS IN EPILEPSIA: PREVALENCE, RISK FACTORS, SYMPTOMS AND THERAPYДЕПРЕССИИ ПРИ ЭПИЛЕПСИИ: РАСПРОСТРАНЕННОСТЬ, ФАКТОРЫ РИСКА, СИМПТОМАТИКА И ТЕРАПИЯКалининВ. В.KalininV. V.

д. м.н., профессор, руководитель отделения экзогенно-органических расстройств и эпилепсии ФГБУ «МНИИП» Минздрава России – филиала ФГБУ «ФМИЦПН им. В. П. Сербского» Минздрава России. Адрес: ул. Потешная, д. 3, Москва, Россия, 107076

MD, Professor, Head of the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076

doct.kalinin@mail.ruЖелезноваЕ. В.ZheleznovaE. V.

д. м.н., ведущий научный сотрудник отделения экзогенно-органических расстройств и эпилепсии ФГБУ «МНИИП» Минздрава России – филиала ФГБУ «ФМИЦПН им. В. П. Сербского» Минздрава России. Адрес: ул. Потешная, д. 3, Москва, Россия, 107076

MD, Leading Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076

e_zheleznova@mail.ruЗемлянаяА. А.ZemlyanayaA. A.

к. м.н., старший научный сотрудник отделения экзогенно-органических расстройств и эпилепсии ФГБУ «МНИИП» Минздрава России – филиала ФГБУ «ФМИЦПН им. В. П. Сербского» Минздрава России. Адрес: ул. Потешная, д. 3, Москва, Россия, 107076

PhD, Senior Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076

a_zemlyanaya@mail.ruСоколоваЛ. В.SokolovaL. V.

к. м.н., старший научный сотрудник отделения экзогенно-органических расстройств и эпилепсии ФГБУ «МНИИП» Минздрава России – филиала ФГБУ «ФМИЦПН им. В. П. Сербского» Минздрава России. Адрес: ул. Потешная, д. 3, Москва, Россия, 107076

PhD, Senior Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076

СубботинК. Ю.SubbotinK. Yu.

младший научный сотрудник отделения экзогенно-органических расстройств и эпилепсии ФГБУ «МНИИП» Минздрава России – филиала ФГБУ «ФМИЦПН им. В. П. Сербского» Минздрава России. Адрес: ул. Потешная, д. 3, Москва, Россия, 107076

Junior Researcher at the Department of exogenous-organic disorders and epilepsy, the Federal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky. Address: ul. Poteshnaya, 3, Moscow, Russia, 107076

a_zemlyanaya@mail.ruФГБУ «ФМИЦПН им. В. П. Сербского» Минздрава РоссииРоссияFederal Medical Research Centre for Psychiatry and Narcology named after V. P. Serbsky, Health Ministry of Russian FederationRussian Federation201709112017934753Copyright © Kalinin V.V., Zheleznova E.V., Zemlyanaya A.A., Sokolova L.V., Subbotin K.Y., 20172017Калинин В.В., Железнова Е.В., Земляная А.А., Соколова Л.В., Субботин К.Ю.Kalinin V.V., Zheleznova E.V., Zemlyanaya A.A., Sokolova L.V., Subbotin K.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/356

The paper reviews the current data on the risk factors, pathogenesis, psychopathological symptoms and therapy of depression in patients with epilepsy. Depression predominantly occurs in patients with temporal epilepsy. The lateralization of the focus cannot be readily interpreted, although the literature indicates that depression occurs more often with left-sided foci. In their external manifestations, the episodes of depression in epilepsy can be fully the same as in any affective disorder. Treatment of depression is carried out without canceling therapy with antiepileptic drugs; the latter may have different impacts on the course of depression. In this respect, valproate, carbamazepine, oxcarbazepine, and lamotrigine do not exacerbate depression. All of them, despite the differences in their mechanisms of action, have a common component – an increase in the serotonin level in the central nervous system. Among the drugs listed above, valproate is especially beneficial.

В работе излагаются современные данные по факторам риска, патогенезу, психопатологической симптоматике и терапии депрессий у больных эпилепсией. Депрессии преимущественно возникают у больных височной эпилепсией. Латерализация фокуса не имеет однозначного значения, хотя литературные данные говорят, что депрессия чаще возникает при левосторонних фокусах. Депрессивные эпизоды при эпилепсии по своим внешним проявлениям могут быть совершенно аналогичны любому аффективному расстройству. Лечение депрессии проводят, не отменяя терапии противоэпилептическими препаратами, которые различаются между собой влиянием на течение депрессии. При этом вальпроаты, карбамазепин, окскарбазапеин и ламотрижин не усугубляют депрессии. Все они, несмотря на различия в механизмах действия, имеют общий компонент – в виде повышения концентрации серотонина в ЦНС. Особыми преимуществами среди перечисленных выше препаратов обладают вальпроаты.

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The authors declare that there are no conflicts of interest present.