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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2077-8333.2017.9.4.041-049</article-id><article-id custom-type="elpub" pub-id-type="custom">epilepsia-370</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC SURVEYS</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group></article-categories><title-group><article-title>MICROSTRUCTURAL AND FUNCTIONAL ABNORMALITIES IN THE BRAIN OF PATIENTS WITH TEMPORAL LOBE EPILEPSY AS REVEALED WITH MR IMAGING</article-title><trans-title-group xml:lang="ru"><trans-title>НЕКОТОРЫЕ ВОПРОСЫ МР-ДИАГНОСТИКИ МИКРОСТРУКТУРНЫХ И ФУНКЦИОНАЛЬНЫХ НАРУШЕНИЙ ГОЛОВНОГО МОЗГА У ПАЦИЕНТОВ С ВИСОЧНОЙ ЭПИЛЕПСИЕЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перепелова</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Perepelova</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Перепелова Елена Михайловна – кандидат медицинских наук, заведующая отделением лучевой диагностики.</p><p>Ул. Трубецкая, 8, стр. 2, Москва, 119048</p></bio><bio xml:lang="en"><p>Perepelova Elena Mikhailovna – MD, PhD, Head of the Department of Radiology.</p><p>Ul. Trubetskaya, 8-2, Moscow, 119048</p></bio><email xlink:type="simple">elena_perepelova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перепелов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Perepelov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Перепелов Всеволод Андреевич – врач-ординатор.</p><p>Ул. Баррикадная, д. 2/1, Москва, 125993</p></bio><bio xml:lang="en"><p>Perepelov Vsevolod Andreevich – MD, Medical Resident.</p><p>Ul. Barrikadnaya, 2/1, Moscow, 125993</p></bio><email xlink:type="simple">sevash84@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Меркулова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Merkulova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Меркулова Мария Сергеевна – врач-ординатор.</p><p>Ул. Баррикадная, д. 2/1, Москва, 125993</p></bio><bio xml:lang="en"><p>Merkulova Mariya Sergeevna – MD, Medical Resident.</p><p>Ul. Barrikadnaya, 2/1, Moscow, 125993</p></bio><email xlink:type="simple">maria_merkulova@yahoo.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)»; Государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия последипломного образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; Russian Medical Academy of Postgraduate Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия последипломного образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Postgraduate Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>22</day><month>02</month><year>2018</year></pub-date><volume>9</volume><issue>4</issue><fpage>41</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Perepelova E.M., Perepelov V.A., Merkulova M.S., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Перепелова Е.М., Перепелов В.А., Меркулова М.С.</copyright-holder><copyright-holder xml:lang="en">Perepelova E.M., Perepelov V.A., Merkulova M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/370">https://www.epilepsia.su/jour/article/view/370</self-uri><abstract><p>Diagnosis of epilepsy remains a challenging task facing physicians of various specialties. When epilepsy is suspected, neuroimaging is one of the major diagnostic tests able to localize the epileptic site and identify the underlying pathology; this information is indispensable in making the diagnosis and predicting the prognosis of the disease. Magnetic resonance imaging (MRI) is the most common modality widely used due to its high sensitivity and specificity in detecting of subtle abnormalities in the brain structure. In addition to the structural pulse sequences, the epilepsy-specific MRIprotocol incorporates a number of recently introduced techniques for the assessment of local functional abnormalities. In this report, the epilepsy-specific protocol that includes the updated pulse sequences technique was used in patients suspected of having temporal lobe epilepsy. Using this technique, characteristic changes in the structure and function of local brain segments in temporal epilepsy were demonstrated.</p></abstract><trans-abstract xml:lang="ru"><p>Диагностика эпилепсии остается одной из актуальных задач, стоящей перед врачами различных специальностей. При обследовании пациентов с подозрением на эпилепсию роль нейровизуализации заключается в локализации и определении характера основной патологии, помощи в формулировании диагноза, а также прогноза течения болезни. Среди нейровизуализационных методик для решения поставленной задачи наибольшее распространение приобрела магнитно-резонансная томография (МРТ), что вызвано ее высокой чувствительностью и специфичностью в отношении локализации мелких нарушений структуры головного мозга. Помимо структурных импульсных последовательностей, эпилептологический МР-протокол включает ряд современных методик, позволяющих оценивать функциональное состояние головного мозга, в том числе и при височной эпилепсии. В настоящей статье представлен протокол с применением современных импульсных последовательностей при обследовании пациента с подозрением на височную эпилепсию, а также рассмотрены наиболее типичные изменения структурного и функционального состояния вещества головного мозга при данной нозологии.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эпилепсия</kwd><kwd>мезиальный темпоральный склероз</kwd><kwd>эпилептологический МР-протокол</kwd><kwd>магнитно-резонансная томография</kwd><kwd>височная эпилепсия</kwd><kwd>повреждение гиппокампа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>epilepsy</kwd><kwd>mesial temporal sclerosis</kwd><kwd>MRI epilepsy protocol</kwd><kwd>temporal epilepsy</kwd><kwd>hippocampal lesion</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Авакян Г.Н., Блинов Д.В., Лебедева А.В., Бурд С. Г., Авакян Г. Г. Классификация эпилепсии Международной противоэпилептической лиги: пересмотр и обновление 2017 года. Эпилепсия и пароксизмальные состояния. 2017; 1: 6-25.</mixed-citation><mixed-citation xml:lang="en">Avakyan G.N., Blinov D.V., Lebedeva A.V., Burd S.G., Avakyan G.G. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2017; 1: 6-25.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Авакян Г.Н. Вопросы современной эпилептологии. Эпилепсия и пароксизмальные состояния. 2015; 7 (4): 16-21.</mixed-citation><mixed-citation xml:lang="en">Avakyan G.N. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2015; 7 (4): 16-21.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин К.Ю. Определение и классификация эпилепсии. Проект классификации эпилептических приступов 2016 года. Русский журнал детской неврологии. 2017; 1: 8-20.</mixed-citation><mixed-citation xml:lang="en">Mukhin K.Yu. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2017; 1: 8-20.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">About ILAE – International League Against Epilepsy. URL: http://www.ilae.org/Visitors/About_ILAE/Index.cfm. Дата обращения: 12.11.2017.</mixed-citation><mixed-citation xml:lang="en">About ILAE – International League Against Epilepsy. URL: http://www.ilae.org/Visitors/About_ILAE/Index.cfm. Accessed: 12.11.2017.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Rodionov R., Bartlett P.A., He C. et al. T2 mapping outperforms normalised FLAIR in identifying hippocampal sclerosis. Neuroimage Clin. 2015; 7: 788-791.</mixed-citation><mixed-citation xml:lang="en">Rodionov R., Bartlett P.A., He C. et al. T2 mapping outperforms normalised FLAIR in identifying hippocampal sclerosis. Neuroimage Clin. 2015; 7: 788-791.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pitkänen A., Sutula T.P. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol. 2002; 1 (3): 173-181.</mixed-citation><mixed-citation xml:lang="en">Pitkänen A., Sutula T.P. Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy. Lancet Neurol. 2002; 1 (3): 173-181.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Blumcke I., Thom M., Aronica E. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a task force report from the ILAE Commission on Diagnostic Methods. Epilepsia. 2013; 54: 1315-1329.</mixed-citation><mixed-citation xml:lang="en">Blumcke I., Thom M., Aronica E. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a task force report from the ILAE Commission on Diagnostic Methods. Epilepsia. 2013; 54: 1315-1329.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mitsueda-Ono T., Ikeda A., Sawamoto N., Aso T., Hanakawa T., Kinoshita M. et al. Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy. Intern Med. 2013. 52 (8): 877-85.</mixed-citation><mixed-citation xml:lang="en">Mitsueda-Ono T., Ikeda A., Sawamoto N., Aso T., Hanakawa T., Kinoshita M. et al. Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy. Intern Med. 2013. 52 (8): 877-85.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Winston G.P., Vos S.B., Burdett J. L., Cardoso M. J., Ourselin S. and Duncan J.S. Automated T2 relaxometry of the hippocampus for temporal lobe epilepsy. Epilepsia. 2017; 58: 1645-1652. doi:10.1111/epi.13843.</mixed-citation><mixed-citation xml:lang="en">Winston G.P., Vos S.B., Burdett J. L., Cardoso M. J., Ourselin S. and Duncan J.S. Automated T2 relaxometry of the hippocampus for temporal lobe epilepsy. Epilepsia. 2017; 58: 1645-1652. doi:10.1111/epi.13843.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Scanlon C., Mueller S.G., Cheong I., Hartig M., Weiner M.W., Laxer K.D. Grey and white matter abnormalities in temporal lobe epilepsy with and without mesial temporal sclerosis. J. Neurol. 2013; 260: 2320-2329.</mixed-citation><mixed-citation xml:lang="en">Scanlon C., Mueller S.G., Cheong I., Hartig M., Weiner M.W., Laxer K.D. Grey and white matter abnormalities in temporal lobe epilepsy with and without mesial temporal sclerosis. J. Neurol. 2013; 260: 2320-2329.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Никитина М.А., Мухин К.Ю., Глухова Л.Ю., Чадаев В.А., Барлетова Е.И. Клинические латерализационные признаки при симптоматической височной эпилепсии. Эпилепсия и пароксизмальные состояния. 2015; 2: 59-64.</mixed-citation><mixed-citation xml:lang="en">Nikitina M.A., Mukhin K.Yu., Glukhova L.Yu., Chadaev V.A., Barletova E. I. Epilepsiya i paroksizmal’nye sostoyaniya / Epilepsy and paroxysmal conditions (in Russian). 2015; 2: 59-64.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Pustina D., Doucet G., Sperling M., Sharan A., Tracy J. Increased microstructural white matter correlations in left, but not right, temporal lobe epilepsy. Hum Brain Mapp. 2015; 36: 85-98.</mixed-citation><mixed-citation xml:lang="en">Pustina D., Doucet G., Sperling M., Sharan A., Tracy J. Increased microstructural white matter correlations in left, but not right, temporal lobe epilepsy. Hum Brain Mapp. 2015; 36: 85-98.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Otte W.M., van Eijsden P., Sander J.W., Duncan J.S., Dijkhuizen R.M., Braun K.P. A meta-analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging. Epilepsia. 2012; 53: 659-667.</mixed-citation><mixed-citation xml:lang="en">Otte W.M., van Eijsden P., Sander J.W., Duncan J.S., Dijkhuizen R.M., Braun K.P. A meta-analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging. Epilepsia. 2012; 53: 659-667.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Concha L., Kim H., Bernasconi A., Bernhardt B.C., Bernasconi N. Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy. Neurology. 2012; 79: 455-462.</mixed-citation><mixed-citation xml:lang="en">Concha L., Kim H., Bernasconi A., Bernhardt B.C., Bernasconi N. Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy. Neurology. 2012; 79: 455-462.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sierra A., Laitinen T., Grohn O., Pitkanen A. Diffusion tensor imaging of hippocampal network plasticity. Brain Struct Funct. 2015; 220 (2): 781-801.</mixed-citation><mixed-citation xml:lang="en">Sierra A., Laitinen T., Grohn O., Pitkanen A. Diffusion tensor imaging of hippocampal network plasticity. Brain Struct Funct. 2015; 220 (2): 781-801.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sagi Y., Tavor I., Hofstetter S., TzurMoryosef S., Blumenfeld-Katzir T., Assaf Y. Learning in the fast lane: new insights into neuroplasticity. Neuron. 2012; 73 (6): 1195-1203.</mixed-citation><mixed-citation xml:lang="en">Sagi Y., Tavor I., Hofstetter S., TzurMoryosef S., Blumenfeld-Katzir T., Assaf Y. Learning in the fast lane: new insights into neuroplasticity. Neuron. 2012; 73 (6): 1195-1203.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sierra A., Grohn O., Pitkanen A. Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis. Neuroscience. 2015; 309: 162-172.</mixed-citation><mixed-citation xml:lang="en">Sierra A., Grohn O., Pitkanen A. Imaging microstructural damage and plasticity in the hippocampus during epileptogenesis. Neuroscience. 2015; 309: 162-172.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lee C.Y., Tabesh A., Benitez A., Helpern J.A., Jensen J.H., Bonilha L. Microstructural integrity of early- versus late-myelinating white matter tracts in medial temporal lobe epilepsy. Epilepsia. 2013; 54: 1801-1809.</mixed-citation><mixed-citation xml:lang="en">Lee C.Y., Tabesh A., Benitez A., Helpern J.A., Jensen J.H., Bonilha L. Microstructural integrity of early- versus late-myelinating white matter tracts in medial temporal lobe epilepsy. Epilepsia. 2013; 54: 1801-1809.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Budde M.D., Janes L., Gold E., Turtzo L.C., Frank J.A. The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections. Brain. 2011; 134 (8): 2248-2260.</mixed-citation><mixed-citation xml:lang="en">Budde M.D., Janes L., Gold E., Turtzo L.C., Frank J.A. The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections. Brain. 2011; 134 (8): 2248-2260.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Slinger G., Sinke M.R.T., Braun K.P.J., Otte W.M. White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis. NeuroImage. 2016; 12:902-909.</mixed-citation><mixed-citation xml:lang="en">Slinger G., Sinke M.R.T., Braun K.P.J., Otte W.M. White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis. NeuroImage. 2016; 12: 902-909.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Diao L., Yu H., Zheng J., Chen Z., Huang D., Yu L. Abnormalities of the uncinate fasciculus correlate with executive dysfunction in patients with left temporal lobe epilepsy. Magn. Reson. Imaging. 2015; 33: 544-550.</mixed-citation><mixed-citation xml:lang="en">Diao L., Yu H., Zheng J., Chen Z., Huang D., Yu L. Abnormalities of the uncinate fasciculus correlate with executive dysfunction in patients with left temporal lobe epilepsy. Magn. Reson. Imaging. 2015; 33: 544-550.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Concha L., Beaulieu C., Collins D. L., Gross D.W. White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis. J. Neurol. Neurosurg. Psychiatry. 2009; 80: 312-319.</mixed-citation><mixed-citation xml:lang="en">Concha L., Beaulieu C., Collins D. L., Gross D.W. White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis. J. Neurol. Neurosurg. Psychiatry. 2009; 80: 312-319.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">McDonald C.R., Ahmadi M. E., Hagler D. J., Tecoma E.S., Iragui V. J., Gharapetian L., Dale A.M., Halgren E. Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy. Neurology. 2008; 71: 1869-1876.</mixed-citation><mixed-citation xml:lang="en">McDonald C.R., Ahmadi M. E., Hagler D. J., Tecoma E.S., Iragui V. J., Gharapetian L., Dale A.M., Halgren E. Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy. Neurology. 2008; 71: 1869-1876.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Riley J.D., Franklin D. L., Choi V., Kim R.C., Binder D.K., Cramer S.C., Lin J. J. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia. 2010; 51: 536-545.</mixed-citation><mixed-citation xml:lang="en">Riley J.D., Franklin D. L., Choi V., Kim R.C., Binder D.K., Cramer S.C., Lin J. J. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia. 2010; 51: 536-545.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Sone D., Matsuda H., Ota M., Maikusa N., Kimura Y., Sumida K., Yokoyama K., Imabayashi E., Watanabe M., Watanabe Y., Okazaki M., Sato N. Impaired cerebral blood flow networks in temporal lobe epilepsy with hippocampal sclerosis: A graph theoretical approach. Epilepsy Behav. 2016 Sep; 62: 239-45. doi: 10.1016/j.yebeh.2016.07.016.</mixed-citation><mixed-citation xml:lang="en">Sone D., Matsuda H., Ota M., Maikusa N., Kimura Y., Sumida K., Yokoyama K., Imabayashi E., Watanabe M., Watanabe Y., Okazaki M., Sato N. Impaired cerebral blood flow networks in temporal lobe epilepsy with hippocampal sclerosis: A graph theoretical approach. Epilepsy Behav. 2016 Sep; 62: 239-45. doi: 10.1016/j.yebeh.2016.07.016.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lim Y.M., Cho Y.W., Shamim S., Solomon J., Birn R., Luh W.M., Gaillard W.D., Ritzl E.K., Theodore W.H. Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy. Epilepsy Res. 2008 Dec; 82 (2-3): 183-9.</mixed-citation><mixed-citation xml:lang="en">Lim Y.M., Cho Y.W., Shamim S., Solomon J., Birn R., Luh W.M., Gaillard W.D., Ritzl E.K., Theodore W.H. Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy. Epilepsy Res. 2008 Dec; 82 (2-3): 183-9.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Sone D., Ota M., Yokoyama K., Sumida K., Kimura Y., Imabayashi E., Matsuda H., Sato N. Noninvasive evaluation of the correlation between regional cerebral blood flow and intraventricular brain temperature in temporal lobe epilepsy. Magn Reson Imaging. 2016 May 18; 34 (4): 451-4.</mixed-citation><mixed-citation xml:lang="en">Sone D., Ota M., Yokoyama K., Sumida K., Kimura Y., Imabayashi E., Matsuda H., Sato N. Noninvasive evaluation of the correlation between regional cerebral blood flow and intraventricular brain temperature in temporal lobe epilepsy. Magn Reson Imaging. 2016 May 18; 34 (4): 451-4.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Guo X., Xu S., Wang G., Zhang Y., Guo L., Zhao B. Asymmetry of cerebral blood flow measured with three-dimensional pseudocontinuous arterial spin-labeling mr imaging in temporal lobe epilepsy with and without mesial temporal sclerosis. J Magn Reson Imaging. 2015; 42 (5): 1386-97.</mixed-citation><mixed-citation xml:lang="en">Guo X., Xu S., Wang G., Zhang Y., Guo L., Zhao B. Asymmetry of cerebral blood flow measured with three-dimensional pseudocontinuous arterial spin-labeling mr imaging in temporal lobe epilepsy with and without mesial temporal sclerosis. J Magn Reson Imaging. 2015; 42 (5): 1386-97.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf R. L., Alsop D.C., Levy-Reis I., Meyer P. T., Maldjian J.A., GonzalezAtavales J., French J.A., Alavi A., Detre J.A. Detection of Mesial Temporal Lobe Hypoperfusion in Patients with Temporal Lobe Epilepsy by Use of Arterial Spin Labeled Perfusion MR Imaging. AJNR Am J Neuroradiol. 2001 Aug; 22 (7): 1334-41.</mixed-citation><mixed-citation xml:lang="en">Wolf R. L., Alsop D.C., Levy-Reis I., Meyer P. T., Maldjian J.A., GonzalezAtavales J., French J.A., Alavi A., Detre J.A. Detection of Mesial Temporal Lobe Hypoperfusion in Patients with Temporal Lobe Epilepsy by Use of Arterial Spin Labeled Perfusion MR Imaging. AJNR Am J Neuroradiol. 2001 Aug; 22 (7): 1334-41.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Yusuf Oner A., Bulent Eryurt, Murat Ucar, Irem Capraz, Gokhan Kurt, Erhan Bilir, Turgut Tali. pASL versus DSC perfusion MRI in lateralizing temporal lobe epilepsy. Acta Radiologica. 2015; 56 (4): 477-81.</mixed-citation><mixed-citation xml:lang="en">Yusuf Oner A., Bulent Eryurt, Murat Ucar, Irem Capraz, Gokhan Kurt, Erhan Bilir, Turgut Tali. pASL versus DSC perfusion MRI in lateralizing temporal lobe epilepsy. Acta Radiologica. 2015; 56 (4): 477-81.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Xu M.Y., Ergene E., Zagardo M., Tracy P. T., Wang H., Liu W., Machens N.A., Proton MR Spectroscopy in Patients with Structural MRI-Negative Temporal Lobe Epilepsy. J Neuroimaging. 2015; 25: 1030-1037. doi: 10.1111/jon.12263.</mixed-citation><mixed-citation xml:lang="en">Xu M.Y., Ergene E., Zagardo M., Tracy P. T., Wang H., Liu W., Machens N.A., Proton MR Spectroscopy in Patients with Structural MRI-Negative Temporal Lobe Epilepsy. J Neuroimaging. 2015; 25: 1030-1037. doi: 10.1111/jon.12263.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Willmann O., Wennberg R., May T. et al. The role of 1H magnetic resonance spectroscopy in pre-operative evaluation for epilepsy surgery. A meta-analysis. Epilepsy Res. 2006; 71: 149-158.</mixed-citation><mixed-citation xml:lang="en">Willmann O., Wennberg R., May T. et al. The role of 1H magnetic resonance spectroscopy in pre-operative evaluation for epilepsy surgery. A meta-analysis. Epilepsy Res. 2006; 71: 149-158.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">McLean M.A., Koepp M., Woermann F.G. Magnetic resonance spectroscopy in patients with epilepsy. In: Luders H (ed) Textbook of epilepsy Surgery. Informa Healthcare. 2008; London.</mixed-citation><mixed-citation xml:lang="en">McLean M.A., Koepp M., Woermann F.G. Magnetic resonance spectroscopy in patients with epilepsy. In: Luders H (ed) Textbook of epilepsy Surgery. Informa Healthcare. 2008; London.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
