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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2077-8333.2018.10.1.014-024</article-id><article-id custom-type="elpub" pub-id-type="custom">epilepsia-389</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>CLINICAL, NEURO-PHYSIOLOGICAL AND NEURO-VISUAL ANALYSIS OF ADULT PATIENTS WITH FOCAL EPILEPSY AND ABNORMALITIES OF CARDIAC RHYTHM AND CONDUCTION IN THE ICTAL PERIOD</article-title><trans-title-group xml:lang="ru"><trans-title>КЛИНИКО-НЕЙРОФИЗИОЛОГИЧЕСКИЕ И НЕЙРОВИЗУАЛИЗАЦИОННЫЕ ХАРАКТЕРИСТИКИ ВЗРОСЛЫХ ПАЦИЕНТОВ С ФОКАЛЬНОЙ ЭПИЛЕПСИЕЙ С НАРУШЕНИЯМИ СЕРДЕЧНОГО РИТМА И ПРОВОДИМОСТИ В ИКТАЛЬНОМ ПЕРИОДЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рублева</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rubleva</surname><given-names>Y. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант,</p><p>ул. Островитянова, 1, Москва 117997</p></bio><bio xml:lang="en"><p>Postgraduate student,</p><p>1 Ostrovityanova Str., Moscow 117997</p></bio><email xlink:type="simple">julia2105@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терян</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Teryan</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, </p><p>Петроверигский переулок, 10-3, Москва 101100</p></bio><bio xml:lang="en"><p>Graduate student,</p><p>Petroverigskii pereulok, 10-3, Moscow 101100</p></bio><email xlink:type="simple">roziteryan@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авакян</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Avakyan</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры неврологии, нейрохирургии и медицинской генетики,</p><p>ул. Островитянова, 1, Москва 117997</p></bio><bio xml:lang="en"><p>MD, PhD, Associate Professor at the Department of Neurology, Neurosurgery and Medical Genetics,</p><p>1 Ostrovityanova Str., Moscow 117997</p></bio><email xlink:type="simple">avakyan_georgy@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савенков</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Savenkov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., заведующий межокружным отделением пароксизмальных состояний</p></bio><bio xml:lang="en"><p>MD, PhD, Head of the Inter-branch Department of Paroxysmal Conditions</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соломатин</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Solomatin</surname><given-names>Y. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>окружной специалист по пароксизмальным состояниям</p></bio><bio xml:lang="en"><p>MD, PhD, Expert in Paroxysmal Diseases</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олейникова</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Oleynikova</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры неврологии, нейрохирургии и медицинской генетики,</p><p>ул. Островитянова, 1, Москва 117997</p></bio><bio xml:lang="en"><p>MD, PhD, Associate Professor at the Department of Neurology, Neurosurgery and Medical Genetics,</p><p>1 Ostrovityanova Str., Moscow 117997</p></bio><email xlink:type="simple">ololeynikova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Теплышова</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Teplysheva</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., окружной специалист по пароксизмальным состояниям</p></bio><bio xml:lang="en"><p>MD, PhD, Expert in Paroxysmal Diseases</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронов</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironov</surname><given-names>M. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., заведующий лабораторией,</p><p>Проспект Андропова, 13/32, Москва 119021</p></bio><bio xml:lang="en"><p>PhD, Head of Laboratory at the Medical Center for Pediatric Neurology and Pediatrics,</p><p>13/32 Andropov Avenue, Moscow 101100</p></bio><email xlink:type="simple">mironovmb@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красильщикова</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasilshchikova</surname><given-names>T. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры неврологии, нейрохирургии и медицинской генетики педиатрического факультета,</p><p>ул. Островитянова, 1, Москва 117997</p></bio><bio xml:lang="en"><p>Assistant, Chair of Neurology, Neurosurgery and Medical Fenetics, Faculty of Pediatrics,</p><p>1 Ostrovityanova Str., Moscow 117997</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурд</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Burd</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета,</p><p>ул. Островитянова, 1, Москва 117997</p></bio><bio xml:lang="en"><p>MD, PhD, Professor at the Chair of Neurology, Neurosurgery and Medical Genetics, Faculty of Pediatrics,</p><p>1 Ostrovityanova Str., Moscow 117997</p></bio><email xlink:type="simple">burds@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр профилактической медицины» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National medical research center of preventive medicine of the Ministry of health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Государственная клиническая больница им. М. Е. Жадкевича ДЗ г. Москвы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Zhadkevich Clinical Hospital, Department of Health, the City of Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ «Диагностический клинический центр № 1 Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The District Healthcare Facility “Diagnostic clinical center No. 1 with the Department of Healthcare of Moscow”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ГБУЗ «Городская поликлиника №62 Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>The District Healthcare Facility “Diagnostic clinical center No. 62 with the Department of Healthcare of Moscow”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Детский медицинский центр неврологии и педиатрии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Medical Center for Pediatric Neurology and Pediatrics</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>05</month><year>2018</year></pub-date><volume>10</volume><issue>1</issue><fpage>14</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Rubleva Y.V., Teryan R.A., Avakyan G.G., Savenkov A.A., Solomatin Y.V., Oleynikova O.M., Teplysheva A.M., Mironov M.B., Krasilshchikova T.M., Burd S.G., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Рублева Ю.В., Терян Р.А., Авакян Г.Г., Савенков А.А., Соломатин Ю.В., Олейникова О.М., Теплышова А.М., Миронов М.Б., Красильщикова Т.М., Бурд С.Г.</copyright-holder><copyright-holder xml:lang="en">Rubleva Y.V., Teryan R.A., Avakyan G.G., Savenkov A.A., Solomatin Y.V., Oleynikova O.M., Teplysheva A.M., Mironov M.B., Krasilshchikova T.M., Burd S.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/389">https://www.epilepsia.su/jour/article/view/389</self-uri><abstract><sec><title>Objective</title><p>Objective. To conduct a survey of adult patients with focal epilepsy and ictal disturbances of cardiac rhythm and conduction, considering the disease classification, anamnesis, clinical, electroencephalographic and neuroimaging data.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. We selected 70 patients aged 18 to 51 years old with confirmed diagnoses of focal epilepsy with epileptic seizures persisting at the time of the study on the background of antiepileptic therapy without concomitant cardiac disorders but with confirmed ictal changes in the cardiac rhythm and conduction.</p></sec><sec><title>Results</title><p>Results. Among the examined patients, those with long lasting “structural focal epilepsy”, frequent epileptic attacks, temporal and frontal-temporal epileptogenic foci, taking several antiepileptic drugs, prevailed. Most of the heart rhythm and conduction abnormalities occurred in male patients with serial paroxysms, bilateral tonic-clonic seizures, or sleep seizures.</p></sec><sec><title>Сonclusion</title><p>Сonclusion. The timely detection and examination of patients with high risk of ictal arrhythmias is able to prevent disturbances of cardiac rhythm and heart conduction during epileptic seizures, including those with a life-threatening potential. </p></sec></abstract><trans-abstract xml:lang="ru"><p>Цель – изучение группы взрослых пациентов с фокальной эпилепсией и установленными иктальными нарушениями сердечного ритма и проводимости с учетом нозологических, анамнестических, клинических, электроэнцефалографических и нейровизуализационных особенностей.</p><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование было отобрано 70 пациентов в возрасте от 18 лет до 51 года с подтвержденным диагнозом фокальная эпилепсия с сохраняющимися на момент исследования эпилептическими приступами на фоне проводимой противоэпилептической терапии без сопутствующей кардиальной патологии с установленными иктальными изменениями сердечного ритма и проводимости.</p></sec><sec><title>Результаты</title><p>Результаты. Среди обследованных больных преобладали пациенты с диагнозом «структурная фокальная эпилепсия», длительным течением заболевания, с частыми эпилептическими приступами, с височной и лобно-височной локализацией эпилептогенного очага, принимающие несколько противоэпилептических препаратов. Наиболее часто нарушения сердечного ритма и проводимости возникали у мужчин, с серийным течением пароксизмов, с билатеральными тонико-клоническими приступами, с приступами, возникающими во время сна.</p></sec><sec><title>Заключение</title><p>Заключение. Своевременное выявление и обследование пациентов из групп высокого риска по иктальным аритмиям позволит предотвратить развитие нарушений ритма и проводимости сердца во время развития эпилептических приступов, в том числе жизнеугрожающего характера. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>фокальная эпилепсия</kwd><kwd>эпилептические приступы</kwd><kwd>видео-ЭЭГ-мониторинг</kwd><kwd>противоэпилептические препараты</kwd><kwd>нарушения сердечного ритма и проводимости</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Focal epilepsy</kwd><kwd>epileptic seizures</kwd><kwd>video EEG monitoring</kwd><kwd>antiepileptic drugs</kwd><kwd>cardiac rhythm and conduction disorders</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nashef L., Garner J.W., Sander D.R., Fish S.D. Shorvon Circumstances of death in sudden death in epilepsy: interviews of bereaved relatives. J. 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