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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2077-8333.2019.11.1.88-96</article-id><article-id custom-type="elpub" pub-id-type="custom">epilepsia-461</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE SURVEY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group></article-categories><title-group><article-title>Association between migraine and vestibular disorders</article-title><trans-title-group xml:lang="ru"><trans-title>Взаимосвязь мигрени и вестибулярных расстройств</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0809-6126</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гассиева</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gassieva</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры нервных болезней и нейрохирургии</p><p>ул. Трубецкая, д. 8, стр. 2, Москва 119048, Россия</p></bio><bio xml:lang="en"><p>MD, PhD Student at the Department of Nervous Diseases and Neurosurgery</p><p>8-2 Trubetskaya Str., Moscow 119048, Russia</p></bio><email xlink:type="simple">dianagassievam@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Замерград</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zamergrad</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м.н., профессор кафедры неврологии, старший научный сотрудник лаборатории, врач</p><p>Баррикадная ул., д. 2/1 стр. 1, Москва 125993, Россия</p><p>ул. Островитянова, д. 1, Москва 117997, Россия</p><p>ул. Фадеева, д. 2, Москва 125047, Россия</p></bio><bio xml:lang="en"><p>MD, Professor at the Department of Neurology, Senior Researcher, Russian Research and Clinical Center of Gerontology, Neurologist</p><p>2/1-1 Barrikadnaja Str., Moscow 125993, Russia</p><p>1 Ostrovityanova Str., Moscow 117997, Russia</p><p>2 Fadeeva Str., Moscow 125047, Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3833-532X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Табеева</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Tabeeva</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м.н., профессор кафедры нервных болезней и нейрохирургии, президент Российского общества по изучению головной боли</p><p>ул. Трубецкая, д. 8, стр. 2, Москва 119048, Россия</p></bio><bio xml:lang="en"><p>MD, Professor at the Department of Nervous Diseases and Neurosurgery, President of the Russian Society for the Study of Headache</p><p>8-2 Trubetskaya Str., Moscow 119048, Russia</p><p> </p></bio><email xlink:type="simple">grtabeeva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="en" id="aff-1"><institution>Sechenov First Moscow State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования»&#13;
ФГБОУВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова»&#13;
Медицинский центр «Гута клиник»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Postgraduate Education&#13;
Pirogov Russian National Research Medical University &#13;
Medical Center “Guta Clinics”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2019</year></pub-date><volume>11</volume><issue>1</issue><fpage>88</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Gassieva D.M., Zamergrad M.V., Tabeeva G.R., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гассиева Д.М., Замерград М.В., Табеева Г.Р.</copyright-holder><copyright-holder xml:lang="en">Gassieva D.M., Zamergrad M.V., Tabeeva G.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/461">https://www.epilepsia.su/jour/article/view/461</self-uri><abstract><p>Dizziness (vertigo) and migraine headache are among the most common neurological disorders. The association of dizziness and migraine in the population occurs more often than these conditions diagnosed separately. The probability of their random coincidence is about 1% among the adult population, and the prevalence of migraines combined with dizziness is 3.2%, i. e. about 3 times higher than a mere coincidence. Epidemiological studies have found that the associations between migraine and vertigo is bi-directional. On the one hand, migraine is more common among patients with dizziness, and on the other hand, dizziness is more common among patients with migraine. Moreover, such comorbidity with dizziness is more typical for migraine, and not for other forms of headache. On this background, the term “migraine-associated dizziness”, or “vestibular migraine” (VM) has been introduced. In 2001, H. Neuhauser et al. proposed a list of diagnostic criteria for VM, and this condition has been recently included in the ICDB-3 beta version as a separate nosological unit. By now, the pathophysiology of the VM is not well understood; the current hypotheses are mainly based on the pathophysiology of migraine itself. Yet, a number of recent studies have made a significant contribution to the understanding of the neurophysiological processes involved in the development of VM. There is a hypothesis that dizziness in migraine represents a migraine aura; this mechanism is based on the phenomenon of spreading cortical depression, i. e., a wave of depolarization that originates in the occipital cortex and slowly moves to the ventrally located areas. Vestibular disorders are known to be caused by the release of neuropeptides (substance P, neurokinin A, calcitonin-like peptide); these peptides stimulate the impulse activity of the sensory epithelium in the inner ear and the vestibular nuclei of the brain stem. In addition to the existence of vestibular migraine, as an independent form of headache, other migraine-associated vestibular disorders have been identified. The most commonly seen are nonspecific symptoms, e. g., motion sickness (that occurs in about 50% of patients), peripheral vestibulopathies, and subclinical vestibular disorders detected in patients with migraine by an instrumental neurovestibular examination in the interictal period. The precise mechanisms of the association between migraine and vertigo are not well understood. Clarifying the clinical and pathophysiological details of the relationship between these conditions is very important for optimal management of patients with migraine. </p></abstract><trans-abstract xml:lang="ru"><p>Головокружение и мигренозная головная боль являются одними из самых распространенных расстройств. Ассоциация головокружения и мигрени встречается в популяции чаще, чем эти состояния в отдельности. Вероятность их случайного совпадения составляет около 1%, что позволяет сделать следующий вывод: среди взрослого населения наличие в анамнезе как мигрени, так и головокружения отмечается примерно в 3 раза чаще, чем это можно было бы наблюдать при простом совпадении, а именно у 3,2% людей в популяции. Эпидемиологические исследования ассоциаций мигрени и головокружения подчеркивают двунаправленный характер взаимоотношений между ними. С одной стороны, мигрень чаще встречается среди пациентов с головокружением, с другой – и головокружение чаще встречается среди пациентов с мигренозной головной болью. Причем такая коморбидность с головокружением характерна в большей степени именно для мигрени, а не для других форм головной боли. Эти данные послужили основанием анализа взаимосвязи между мигренью и головокружением, легли в основу представления о мигрень-ассоциированном головокружении, или о вестибулярной мигрени (ВМ). В 2001 г. H. Neuhauser с соавт. предложили диагностические критерии вестибулярной мигрени, благодаря которым ВМ совсем недавно была включена в МКГБ-3 бета-версии как самостоятельная нозологическая единица. Патофизиология ВМ на сегодняшний день недостаточно известна, текущие гипотезы основываются главным образом на знании патофизиологии самой мигрени. Тем не менее за последние несколько лет проведено множество исследований, которые вносят значительный вклад в понимание нейрофизиологических процессов, участвующих в развитии ВМ. Существует гипотеза, согласно которой головокружение при мигрени рассматривается как мигренозная аура, в основе которой лежит феномен распространяющейся корковой депрессии, представляющей собой волну деполяризации, которая зарождается в затылочной коре и медленно продвигается в более вентрально расположенные зоны. Вестибулярные нарушения также могут быть обусловлены высвобождением нейропептидов (субстанция Р, нейрокинин А, кальцитониноподобный пептид), которые обладают стимулирующим действием на импульсную активность сенсорного эпителия внутреннего уха и вестибулярных ядер ствола мозга. Помимо существования вестибулярной мигрени, как самостоятельной формы головной боли, можно выделить и другие мигрень-ассоциированные вестибулярные расстройства, наиболее частыми из которых являются такие неспецифические симптомы, как укачивание или болезнь движения, встречающиеся примерно у 50% пациентов, периферические вестибулопатии и субклинические вестибулярные нарушения, выявляемые у пациентов с мигренью только при специализированном инструментальном нейровестибулярном исследовании в межприступном периоде. Точные механизмы этих ассоциаций пока недостаточно изучены. Уточнение клинических и патофизиологических деталей взаимосвязи этих состояний представляется весьма важным для оптимального ведения больных с мигренью.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мигрень</kwd><kwd>головокружение</kwd><kwd>субклинические вестибулярные нарушения</kwd><kwd>болезнь движения</kwd><kwd>периферические вестибулопатии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Migraine</kwd><kwd>dizziness</kwd><kwd>subclinical vestibular disorders</kwd><kwd>motion sickness</kwd><kwd>peripheral vestibulopathy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lempert T., Neuhauser H. Epidemiology of vertigo, migraine and vestibular migraine. J Neurol. 2009; 256 (3): 333-338.</mixed-citation><mixed-citation xml:lang="en">Lempert T., Neuhauser H. Epidemiology of vertigo, migraine and vestibular migraine. 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