References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2020.054

epilepsia-626

Research Article

EVENTS

СОБЫТИЯ

Results of the expert forum on the use of perampanel in adolescents with epilepsy in everyday clinical practice

Итоги форума экспертов по вопросам применения перампанела у подростков с эпилепсией в условиях повседневной клинической практики

Редакционная

статья

Editorial

Article

2020

24022021

124248261

2021

Редакционная с.

Editorial a.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/626

In June 2020, an online forum of experts on the use of perampanel in adolescents with epilepsy in everyday clinical practice was held. The main goal was to discuss the features of juvenile epilepsy, its diagnosis, the possibilities of using perampanel in this category of patients, and the effectiveness of using the drug in everyday clinical practice. The forum was attended by leading experts in neurology and epileptology. Current data on the epidemiology of epilepsy in the child and juvenile population were presented; the issues of difficulties and diagnostic errors were considered, as well as features of managing adolescents with epilepsy, adverse events of antiepileptic therapy, results of studies on the effectiveness of perampanel, and many social aspects of the life of patients in this category.

В июне 2020 г. в онлайн-формате состоялся форум экспертов по вопросам применения лекарственного препарата перампанел у подростков с эпилепсией в повседневной клинической практике. Основной целью было обсуждение особенностей эпилепсии у подростков, ее диагностики, возможности применения перампанела у данной категории пациентов и эффективности использования препарата в условиях повседневной клинической практики. В работе форума приняли участие ведущие эксперты в области неврологии и эпилептологии. Были представлены актуальные данные по эпидемиологии эпилепсии в детской и подростковой популяции, рассмотрены вопросы сложностей и ошибок диагностики, особенности ведения подростков с эпилепсией, нежелательные явления противоэпилептической терапии, результаты исследований эффективности перампанела, а также множество социальных аспектов жизни пациентов данной категории.

эпилепсияподросткиособенности веденияошибки диагностикиперампанелклиническая практикакогнитивные нарушениякомплаентностьсоциальные аспектыкачество жизни

epilepsyadolescentsmanagement featuresdiagnostic errorsperampanelclinical practicecognitive disorderscompliancesocial aspectsquality of life

Статья выпущена при финансовой поддержке компании «Эйсай». Авторы несут полную ответственность за содержание статьи и редакционные решения.

This article was published with the financial support of Eisai. The authors are fully responsible for the content of the article and editorial decisions.

References1

Wheless J.W., Kim H.L. Adolescent seizures and epilepsy syndromes. Epilepsia. 2002; 43 (Suppl 3): 33–52. https://doi.org/10.1046/j.1528-1157.43.s.3.12.x.

Мухин К.Ю., Петрухин А.С. Идиопатические формы эпилепсии: систематика, диагностика, терапия. М.: Арт-Бизнес-Центр; 2000: 176–88.

Mukhin К.Yu., Petrukhin А.S. Idiopathic forms of epilepsy: taxonomy, diagnosis, and therapy. Мoscow: Art-Biznes-Tsentr; 2000: 176–88 (in Russ.).

Temkin O. The falling sickness: a history of epilepsy from the Greeks to the beginnings of modern neurology. Baltimore: Johns Hopkins Press; 1945. https://doi.org/10.1002/1097-4679(194607)2:3<301::AIDJCLP2270020319>3.0.CO;2-7.

Bandler B., Dykens J.W., Kaufman I.C., et al. Seizures and the menstrual cycle. Am J Psychiatry. 1957; 113 (8): 704–8. https://doi.org/10.1176/ajp.113.8.704.

Logothetis J., Harner R., Morrell F., Torres F. The role of estrogens in catamenial exacerbation of epilepsy. Neurology. 1959; 9 (5): 352–60. https://doi.org/10.1212/wnl.9.5.352.

Delgado-Escueta A.V., Medina M.T., Serratosa J.M., et al. Mapping and positional cloning of common idiopathic generalized epilepsies: juvenile myoclonic epilepsy and childhood absence epilepsy. Adv Neurol. 1999; 79: 351–74.

Reutens D.C., Berkovic S.F. Idiopathic generalized epilepsy of adolescence: are the syndrome sclinically distinct? Neurology. 1995; 45 (8): 1469–76. https://doi.org/10.1212/wnl.45.8.1469.

Janz D. The idiopathic generalized epilepsies of adolescence with childhood and juvenile age of onset. Epilepsia. 1997; 38 (1): 4–11. https://doi.org/10.1111/j.1528-1157.1997.tb01073.x.

Montalenti E., Imperiale D., Rovera A., et al. Clinical features, EEG findings and diagnostic pitfalls in juvenile myoclonic epilepsy: a series of 63 patients. J Neurol Sci. 2001; 184 (1): 65–70. https://doi.org/10.1016/s0022-510x(00)00496-2.

Currie S., Heathfield K.W., Henson R.A., Scott D.F. Clinical course and prognosis of temporal lobe epilepsy. A survey of 666 patients. Brain. 1971; 94 (1): 173–90. https://doi.org/10.1093/brain/94.1.173.

Ramos-Lizana J., Cassinello-García E., Carrasco-Marina L., et al. Remission of epilepsy after onset of antiepileptic treatment: a prospective study in childhood. Rev Neurol. 2001; 33 (11): 1021–6 (in Spanish).

Kotsopoulos I.A., van Merode T., Kessels F.G., et al. Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia. 2002; 43 (11): 1402–9. https://doi.org/10.1046/j.1528-1157.2002.t01-1-26901.x.

Cloyd J., Hauser W., Towne A., et al. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Res. 2006; 68 (Suppl 1): S39–48. https://doi.org/10.1016/j.eplepsyres.2005.07.016.

Engel J., Pedley T.A. Epilepsy: a comprehensive textbook. 2nd ed. Lippincott Williams & Wilkins; 2008.

Annegers J.F., Hauser W.A., Lee J.R., Rocca W.A. Incidence of acute symptomatic seizures in Rochester, Minnesota, 1935–1984. Epilepsia. 1995; 36 (4): 327–33. https://doi.org/10.1111/j.1528-1157.1995.tb01005.x.

Гузева В.В. Клинико-эпидемиологическая характеристика эпилепсии у детей Ленинградской области. В кн.: Гузева В.В., Гузева О.В. (ред.) Материалы студенческой научной конференции. 28–29 апреля 2005 г. Ч. 1. СПб.: СПб ГПМА; 2005: 18–9.

Guzeva V.V. Clinical and epidemiological characteristics of epilepsy in children of the Leningrad region. In: Guzeva V.V., Guzeva О.V. (Eds.) Materials of the Student Scientific Conference. April 28–29, 2005. P. 1. Saint-Petersburg: SPb GPMA; 2005: 18–9 (in Russ.).

Fisher R.S., Acevedo C., Arzimanoglou A., et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014; 55 (4): 475–82. https://doi.org/10.1111/epi.12550.

Noachtar S., Carreno M., Foldvary N., Lüders H.O. Seizures and pseudoseizures. Suppl Clin Neurophysiol. 2000; 53: 259–70.

Uldall P., Alving J., Hansen L.K., et al. The misdiagnosis of epilepsy in children admitted to a tertiary epilepsy center with paroxysmal events. Arch Dis Child. 2006; 91 (3): 219–21. https://doi.org/10.1136/adc.2004.064477.

International League Against Epilepsy. Diagnostic manual. Epilepsy imitators. Available at: https://www.epilepsydiagnosis.org/epilepsyimitators.html (accessed December 23, 2020).

Айвазян С.О. Неэпилептические пароксизмальные состояния, имитирующие эпилепсию у детей. Эпилепсия и пароксизмальные состояния. 2016; 8 (4): 23–33. https://doi.org/10.17749/2077-8333.2016.8.4.023-033.

Aivazyan S.O. Non epileptic paroxysmal events imitating epilepsy in children. Epilepsy and Paroxysmal Conditions. 2016; 8 (4): 23–33 (in Russ.). https://doi.org/10.17749/2077-8333.2016.8.4.023-033.

Smith P.E. The teenager with epilepsy: has special needs. BMJ. 1998; 317 (7164): 960–1. https://doi.org/10.1136/bmj.317.7164.960.

Lerner R.M., Steinberg L. The scientific study of adolescent development. In: Lerner R.M., Steinberg L. (Eds.) Handbook of adolescent psychology. 3rd ed. Hoboken: Wiley; 2009.

Casey B.J., Jones R.M., Hare T.A. The adolescent brain. Ann N Y Acad Sci. 2008; 1124: 111–26. https://doi.org/10.1196/annals.1440.010.

Sørensen K., Mouritsen A., Aksglaede L., et al. Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty. Horm Res Paediatr. 2012; 77 (3): 137–45. https://doi.org/10.1159/000336325.

Lossius M.I., Alfstad K.Å., Van Roy B., et al. Early sexual debut in Norwegian youth with epilepsy: a population-based study. Epilepsy Behav. 2016; 56: 1–4. https://doi.org/10.1016/j.yebeh.2015.12.014.

Camfield P., Camfield C., Busiah K., et al. The transition from pediatric to adult care for youth with epilepsy: basic biological, sociological, and psychological issues. Epilepsy Behav. 2017; 69: 170–6. https://doi.org/10.1016/j.yebeh.2016.11.009.

Baker G., Spector S., McGrath Y., Soteriou H. Impact of epilepsy in adolescence: a UK controlled study. Epilepsy Behav. 2005; 6 (4): 556–62. https://doi.org/10.1016/j.yebeh.2005.03.011.

Asato M.R., Manjunath R., Sheth R.D., et al. Adolescent and caregiver experiences with epilepsy. J Child Neurol. 2009; 24 (5): 562–71. https://doi.org/10.1177/0883073809332396.

Camfield P.R., Andrade D., Camfield C.S., et al. How can transition to adult care be best orchestrated for adolescents with epilepsy? Epilepsy Behav. 2019; 93: 138–47. https://doi.org/10.1016/j.yebeh.2018.12.015.

Leppik I.E. Сompliance during treatment of epilepsy. Epilepsia. 1988; 29 (Suppl 2): S79–84. https://doi.org/10.1111/j.1528-1157.1988.tb05801.x.

Jin J., Sklar G.E., Oh M.N., Li S.C. Factors affecting therapeuticcompliance: a review from the patient’s perspective. Ther Clin Risk Manag. 2008; 4 (1): 269–86.

Bond W.S., Hussar D.A. Detection methods and strategies for improving medication compliance. Am J Hosp Pharm. 1991; 48 (9): 1978–88.

Семенова О.Н., Наумова Е.А. Факторы, влияющие на приверженность к терапии: параметры ВОЗ и мнение пациентов кардиологического отделения. Бюллетень медицинских интернет-конференций. 2013; 3 (3): 507–11.

Semenova О.N., Naumova Е.А. Factors influencing adherence to therapy: WHO parameters and opinion of patients in the cardiology department. Bulletin of Medical Internet Conferences. 2013; 3 (3): 507–11 (in Russ.).

Trostle J. Doctors’ orders and patients’ self–interest: two views of medication usage. In: Schmidt D., Leppik I.E. (Eds.) Compliance in epilepsy. NY: Elsevier Science Publishers BV (Biomedical Division); 1988: 57–69.

Mitchell W.G., Scheier L.M., Baker S.A. Adherence to treatment in children with epilepsy: who follows “doctor's orders”? Epilepsia. 2000; 41 (12): 1616–25. https://doi.org/10.1111/j.1499-1654.2000.001616.x.

Cramer J.A. The Titanic impact of medication compliance–adherence on epilepsy. Available at: https://www.epilepsy.com/article/2014/3/titanic-impact-medication-compliance-epilepsy (accessed December 23, 2020).

Buck D., Jacoby A., Baker G.A., Chadwick D.W. Factors influencing compliance with antiepileptic drug regimes. Seizure. 1997; 6 (2); 87–93. https://doi.org/10.1016/s1059-1311(97)80060-x.

Ермоленко Н.А., Бучнева И.А. Выбор первичной антиэпилептической терапии у подростков. Эпилепсия.Меди.ру. 2013; 2 (10): 3–8.

Ermolenko N.А., Buchneva I.А. The choice of the initial antiepileptic therapy in adolescents. Epilepsiya.Medi.ru. 2013; 2 (10): 3–8 (in Russ.).

Kyngäs H. Predictors of good compliance in adolescents with epilepsy. Seizure. 2001; 10 (8); 549–53. https://doi.org/10.1053/seiz.2001.0557.

Faught E., Duh M.S., Weiner J.R., et al. Nonadherence to antiepileptic drugs and increased mortality: findings from the RANSOM Study. Neurology. 2008; 71 (20): 1572–8. https://doi.org/10.1212/01.wnl.0000319693.10338.b9.

Paschal A.M., Hawley S.R., Romain T.S., Ablah E. Measures of adherence to epilepsy treatment: review of present practices and recommendations for future directions. Epilepsia. 2008; 49 (7): 1115–22. https://doi.org/10.1111/j.1528-1167.2008.01645.x.

Койчуев А.А. Приверженность в лечении: методики оценки, технологии коррекции недостаточной приверженности терапии. Медицинский вестник Северного Кавказа. 2013; 8 (3): 65–9.

Koychuev А.А. Adherence to treatment: assessment methods, technologies for correcting insufficient adherence to therapy. Medical News of North Caucasus. 2013; 8 (3): 65–9 (in Russ.).

Meador K.J., Yang H., Pina-Garza J.E., et al. Cognitive effects of adjunctive perampanel for partial-onset seizures: a randomized trial. Epilepsia. 2016; 57 (2): 243–51. https://doi.org/10.1111/epi.13279.

Piña-Garza J.E., Rosenfeld W., Saeki K., et al. Efficacy and safety of adjunctive perampanel in adolescent patients with epilepsy: post hoc analysis of six randomized studies. Epilepsy Behav. 2020; 104 (Pt A): 106876. https://doi.org/10.1016/j.yebeh.2019.106876.

Kim H.D., Chi C.S., Desudchit T., et al. Review of clinical studies of perampanel in adolescent patients. Brain Behav. 2016; 6 (9): e00505. https://doi.org/10.1002/brb3.505.

Nikanorova M., Olofsson K., Ehrenreich K., et al. Perampanel in children with focal epilepsy: which factors may influence its efficacy? Epilepsia. 2019; 60 (S2): 106–7.

Kim E.H., Ko T.S. Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes. Korean J Pediatr. 2016; 59 (4): 155–64. https://doi.org/10.3345/kjp.2016.59.4.155.

Fastenau P.S., Johnson C.S., Perkins S.M., et al. Neuropsychological status at seizure onset in children: risk factors for early cognitive deficits. Neurology. 2009; 73 (7): 526–34. https://doi.org/10.1212/WNL.0b013e3181b23551.

Nicolai J., Ebus S., Biemans D.P., et al. The cognitive effects of interictal epileptiform EEG discharges and short nonconvulsive epileptic seizures. Epilepsia. 2012; 53 (6): 1051–9. https://doi.org/10.1111/j.1528-1167.2012.03491.x.

Witt J.A., Alpherts W., Helmstaedter C. Computerized neuropsychological testing in epilepsy: overview of available tools. Seizure. 2013; 22 (6): 416–23. https://doi.org/10.1016/j.seizure.2013.04.004.

Witt J.A., Helmstaedter C. Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients. J Neurol. 2012; 259 (8): 1727–31. https://doi.org/10.1007/s00415-012-6526-2.

Helmstaedter C., Witt J.A. Clinical neuropsychology in epilepsy: theoretical and practical issues. Handb Clin Neurol. 2012; 107: 437–59. https://doi.org/10.1016/B978-0-444-52898-8.00036-7.

Whooley M.A., Avins A.L., Miranda J., Browner W.S. Case-finding instruments for depression: Two questions are as good as many. J Gen Intern Med. 1997; 12 (7): 439–45. https://doi.org/10.1046/j.1525-1497.1997.00076.x.

Hanaya R., Arita K. The new antiepileptic drugs: their neuropharmacology and clinical indications. Neurol Med Chir (Tokyo). 2016; 56 (5): 205–20. https://doi.org/10.2176/nmc.ra.2015-0344.

Trinka E.,Carreno M. Reflections on the use of perampanel in epilepsy – lessons from the clinic and real-world evidence. Eur Neurol Rev. 2017; 12 (1): 17–23. https://doi.org/10.17925/ENR.2017.12.01.17.

Gaitatzis A., Carroll K., Majeed A., Sander J.W. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia. 2004; 45 (12): 1613–22. https://doi.org/10.1111/j.0013-9580.2004.17504.x.

Kanner A.M., Patten A., Malhotra M. Perampanel in patients with a history of psychiatric illness: post hoc analysis of four randomized phase III studies (304, 305, 306, and 335) and their open-label extensions (307 and 335 OLEx) (1850). Presentation. Available at: https://cslide-us.ctimeetingtech.com/aan2020/attendee/eposter/poster/3201 (accessed December 23, 2020).

Саржина М.Н., Бурд C.Г., Миронов М.Б. и др. Преемственность оказания специализированной помощи при переводе подростков с эпилепсией из педиатрической службы во взрослую амбулаторную сеть. Эпилепсия и пароксизмальные состояния. 2019; 11 (4): 348–56. https://doi.org/10.17749/2077-8333.2019.11.4.348-356.

Sarzhina M.N., Burd S.G., Mironov M.B., Gunchenko M.M., Batysheva T.T. Continuity of specialized care upon transfer of adolescents with epilepsy from a pediatric to adult outpatient service. Epilepsy and Paroxysmal Conditions. 2019; 11 (4): 348–56 (in Russ.). https://doi.org/10.17749/2077-8333.2019.11.4.348-356.

Rea R., Traini E., Renna R., et al. Efficacy and impact on cognitive functions and quality of life of perampanel as first add-on therapy in patients with epilepsy: a retrospective study. Epilepsy Behav. 2019; 98 (Pt A): 139–44. https://doi.org/10.1016/j.yebeh.2019.07.005.

The authors declare that there are no conflicts of interest present.