References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2021.049

epilepsia-657

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Acute symptomatic seizures during haematopoietic stem cell transplantation

Остро возникшие симптоматические эпилептические приступы при проведении трансплантации гемопоэтических стволовых клеток

https://orcid.org/0000-0003-1955-1032

Скиба

Я. Б.

Skiba

Ya. B.

Скиба Ярослав Богданович, к.м.н., врач-невролог Научно-исследовательского института детской онкологии, гематологии и трасплантологии им. Р.М. Горбачевой

Scopus Author ID: 57211950985

WoS ResearcherID: ABC-9723-2020

РИНЦ SPIN-код: 1273-0742

ул. Льва Толстого, д. 6-8, Санкт-Петербург 197022

Yaroslav B. Skiba, MD, PhD, Neurologist, Gorbacheva Research Institute of Pediatric Oncology, Hematology and TrasplantologyScopus Author ID: 57211950985

WoS ResearcherID: ABC-9723-2020

RSCI SPIN-code: 1273-0742

6-8 Lev Tolstoi Str., Saint Petersburg 197022

yaver-99@mail.ru

https://orcid.org/0000-0001-8699-2482

Полушин

А. Ю.

Polushin

A. Yu.

Полушин Алексей Юрьевич, к.м.н., ассистент кафедры неврологии, врач-невролог Научно-исследовательского института детской онкологии, гематологии и трасплантологии им. Р.М. Горбачевой

Scopus Author ID: 57195962540

РИНЦ SPIN-код: 8123-7779

ул. Льва Толстого, д. 6-8, Санкт-Петербург 197022

Aleksey Yu. Polushin, MD, PhD, Assistant Professor, Chair of Neurology, Neurologist, Gorbacheva Research Institute of PediatricOncology, Hematology and Trasplantology

Scopus Author ID: 57195962540

RSCI SPIN-code: 8123-7779

6-8 Lev Tolstoi Str., Saint Petersburg 197022

https://orcid.org/0000-0003-1545-8877

Прокудин

М. Ю.

Prokudin

M. Yu.

Прокудин Михаил Юрьевич, к.м.н., преподаватель кафедры нервных болезней им. М.И. Аствацатурова

РИНЦ SPIN-код: 4021-4432

ул. Льва Толстого, д. 6-8, Санкт-Петербург 197022

Mikhail Yu. Prokudin, MD, PhD, Astvatsaturov Chair of Nervous Diseases

RSCI SPIN-code: 4021-4432

6-8 Lev Tolstoi Str., Saint Petersburg 197022

https://orcid.org/0000-0002-0215-4623

Владовская

М. Д.

Vladovskaya

M. D.

Владовская Мария Давидовна, к.м.н., заведующая отделением госпитальных регистров Научно-исследовательского института детской онкологии, гематологии и трасплантологии им. Р.М. Горбачевой

Scopus Author ID: 57194451100

РИНЦ SPIN-код: 9257-2440

ул. Льва Толстого, д. 6-8, Санкт-Петербург 197022

Mariya D. Vladovskaya, MD, PhD, Head of the Department of Hospital Registers, Gorbacheva Research Institute of PediatricOncology, Hematology and Trasplantology

Scopus Author ID: 57194451100

RSCI SPIN-code: 9257-2440

6-8 Lev Tolstoi Str., Saint Petersburg 197022

https://orcid.org/0000-0002-9589-4136

Кулагин

А. Д.

Kulagin

A. D.

Кулагин Александр Дмитриевич – д.м.н., и.о. директора Научно-исследовательского института детской онкологии, гематологии и трасплантологии им. Р.М. Горбачевой

Scopus Author ID: 7003340367

WoS ResearcherID: L-9795-2014

РИНЦ SPIN-код: 2667-4966

ул. Льва Толстого, д. 6-8, Санкт-Петербург 197022

Aleksandr D. Kulagin, Dr. Med. Sc., Acting Director, Gorbacheva Research Institute of Pediatric Oncology, Hematology andTrasplantology

Scopus Author ID: 7003340367

WoS ResearcherID: L-9795-2014

RSCI SPIN-code: 2667-4966

6-8 Lev Tolstoi Str., Saint Petersburg 197022

Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияPavlov First Saint Petersburg State Medical UniversityRussian Federation

2021

23042021

1316582

2021

Скиба Я.Б., Полушин А.Ю., Прокудин М.Ю., Владовская М.Д., Кулагин А.Д.

Skiba Y.B., Polushin A.Y., Prokudin M.Y., Vladovskaya M.D., Kulagin A.D.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/657

Acute symptomatic epileptic seizures are one of the complications of hematopoietic stem cell transplantation. The etiological factors leading to the development of this complication differ from those in the general population, while the significance of each of them is different depending on the time after transplantation. We analyze the literature data on the role of drugs, metabolic disorders and infectious complications, as well as the structural pathology of the brain substance in the development of acute symptomatic seizures in patients with oncohematological pathology. We also consider the clinical features of symptomatic epileptic seizures and the possible prognostic significance of their development in patients who underwent hematopoietic stem cell transplantation.

Одним из осложнений трансплантации гемопоэтических стволовых клеток у пациентов онкогематологического профиля являются остро возникшие симптоматические эпилептические приступы. Этиологические факторы, приводящие к развитию данного осложнения, отличаются от таковых в общей популяции, при этом значимость каждого из них различна в зависимости от сроков после трансплантации. В статье проанализированы данные литературы, посвященной роли лекарственных препаратов, метаболических нарушений и инфекционных осложнений, а также структурной патологии вещества головного мозга в развитии симптоматических эпилептических приступов у больных онкогематологического профиля. Рассмотрены их клинические особенности и возможное прогностическое значение их развития у пациентов, перенесших трансплантацию гемопоэтических стволовых клеток.

Эпилептический приступлейкозтрансплантациягемопоэтические стволовые клеткибусульфанонкологические заболеванияаллогенная трансплантация

Epileptic seizureleukemiatransplantationhematopoietic stem cellsbusulfancancerallogeneic transplantation.

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The authors declare that there are no conflicts of interest present.