References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2021.051

epilepsia-696

Research Article

LECTURES

ЛЕКЦИИ

Pharmacological predictors of heart rate and conductivity disorders in juvenile myoclonic epilepsy

Фармакологические предикторы нарушения сердечного ритма и проводимости при юношеской миоклонической эпилепсии

https://orcid.org/0000-0002-2840-837X

Шнайдер

Н. А.

Shnayder

N. A.

Шнайдер Наталья Алексеевна – д.м.н., профессор, ведущий научный сотрудник отделения персонализированной психиатрии и неврологии ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии им. В. М. Бехтерева» Минздрава России; ведущий научный сотрудник центра коллективного пользования «Молекулярные и клеточные технологии» ФГБОУ ВО «Красноярский государственный медицинский университет им. профессора В. Ф. Войно-Ясенецкого» Минздрава России

WoS ResearcherID: M-7084-2014; РИНЦ SPIN-код: 1952-3043

ул. Партизана Железняка, д. 1, Красноярск 660022

ул. Бехтерева, д. 3, Санкт-Петербург 192019

Natalia A. Shnayder – Dr. Med. Sc., Professor, Leading Researcher, Department of Personalized Psychiatry and Neurology, Bekhterev National Medical Research Centre for Psychiatry and Neurology; Leading Researcher, Center of Collective Usage “Molecular and Cellular Technologies”, Krasnoyarsk State Medical University

WoS ResearcherID: M-7084-2014; RSCI SPIN-code: 1952-304

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

3 Bekhterev Str., Saint Petersburg 192019

naschnaider@yandex.ru

https://orcid.org/0000-0002-8493-0058

Петрова

М. М.

Petrova

M. M.

Петрова Марина Михайловна – д.м.н., профессор, заведующая кафедрой поликлинической терапии и семейной медицины с курсом последипломного образования

Scopus Author ID: 23987271200; WoS ResearcherID: L-5623-2014; РИНЦ SPIN-код: 5563-1009

ул. Партизана Железняка, д. 1, Красноярск 660022

Marina M. Petrova – Dr. Med. Sc., Professor, Chief of Chair of Outpatient Therapy and General Practice with the Course of Postgraduate Education

Scopus Author ID: 23987271200; WoS ResearcherID: L-5623-2014; RSCI SPIN-code: 5563-1009

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0000-0002-6116-1292

Петров

К. В.

Petrov

K. V.

Петров Кирилл Владимирович – врач-ординатор кафедры нервных болезней с курсом последипломного образования

РИНЦ SPIN-код: 5830-0594

ул. Партизана Железняка, д. 1, Красноярск 660022

Kirill V. Petrov – Resident Physician, Chair of Neurological Diseases with the Course of Postgraduate Education

RSCI SPIN-code: 5830-0594

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0000-0003-1874-9434

Насырова

Р. Ф.

Nasyrova

R. F.

Насырова Регина Фаритовна – д.м.н., главный научный сотрудник, руководитель отделения персонализированной психиатрии и неврологии

РИНЦ SPIN-код: 1952-3043

ул. Бехтерева, д. 3, Санкт-Петербург 192019

Regina F. Nasyrova – Dr. Med. Sc., Senior Researcher, Head of the Department of Personalized Psychiatry and Neurology

RSCI SPIN-code: 1952-3043

3 Bekhterev Str., Saint Petersburg 192019

Федеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет им. профессора В. Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр психиатрии и неврологии им. В. М. Бехтерева» Министерства здравоохранения Российской ФедерацииРоссияKrasnoyarsk State Medical University; Bekhterev National Medical Research Centre for Psychiatry and NeurologyRussian Federation

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр психиатрии и неврологии им. В. М. Бехтерева» Министерства здравоохранения Российской ФедерацииРоссияBekhterev National Medical Research Centre for Psychiatry and NeurologyRussian Federation

2021

21072021

132168179

2021

Шнайдер Н.А., Петрова М.М., Петров К.В., Насырова Р.Ф.

Shnayder N.A., Petrova M.M., Petrov K.V., Nasyrova R.F.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/696

Juvenile myoclonic epilepsy (JME) is the most common form of genetic generalized epilepsy. Patients with JME are at risk of life-threatening heart rhythm and conduction disorders as well as sudden death syndrome due to several potential mechanisms: genetic, clinical, neuroanatomical, pharmacological, psychological, comorbid. This lecture reviews important elements of knowledge about the pharmacological predictors of cerebral-cardiac syndrome and sudden unexpected death in epilepsy. The arrhythmogenic potential of antiepileptic drugs most often used in JME (valproic acid, levetiracetam, lamotrigine, topiramate and zonisamide) is considered, none of which can be classified as class A (drug without risk of QT interval prolongation or TdP) regarding a risk of QT interval prolongation and cardiac arrhythmias. Patients with JME require dynamic video-electroencephalographic monitoring and 24-hour electrocardiographic monitoring to reduce a risk of life-threatening cardiac arrhythmias.

Юношеская миоклоническая эпилепсия (ЮМЭ) является наиболее распространенной формой генетической генерализованной эпилепсии. Пациенты с ЮМЭ имеют риск жизнеугрожающих нарушений сердечного ритма и проводимости, а также синдрома внезапной смерти, обусловленных несколькими потенциальными механизмами: генетическими, клиническими, нейроанатомическими, фармакологическими, психологическими, коморбидными. В лекции рассмотрены важные элементы знаний о фармакологических предикторах цереброкардиального синдрома и синдрома внезапной смерти при эпилепсии. Показан аритмогенный потенциал противоэпилептических препаратов, наиболее часто применяющихся при ЮМЭ: вальпроевой кислоты, леветирацетама, ламотриджина, топирамата и зонисамида. Ни один из них по риску удлинения интервала QT и сердечных аритмий нельзя отнести к классу А (препараты без риска удлинения интервала QT или TdP). Пациенты с ЮМЭ нуждаются как в динамическом видеоэлектроэнцефалографическом мониторинге, так и в суточном электрокардиографическом мониторинге для снижения риска жизнеугрожающих сердечных аритмий.

цереброкардиальный синдромсердечный ритмэпилепсияюношеская миоклоническая эпилепсиявнезапная сердечная смертьсиндром внезапной смерти при эпилепсиипротивоэпилептические препаратывальпроевая кислоталеветирацетамламотриджинтопираматзонисамид

cerebral-cardiac syndromeheart rhythmepilepsyjuvenile myoclonic epilepsysudden cardiac deathsudden unexpected death in epilepsyantiepileptic drugsvalproic acidlevetiracetamlamotriginetopiramatezonisamide

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The authors declare that there are no conflicts of interest present.