epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLC10.17749/2077-8333/epi.par.con.2021.094epilepsia-750Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИMetabolic disorders in patients with vestibular migraineМетаболические нарушения у пациентов с вестибулярной мигреньюhttps://orcid.org/0000-0003-1570-6607БеденкоА. С.BedenkoA. S.

Беденко Анна Сергеевна – аспирант кафедры нервных болезней и нейрохирургии

РИНЦ SPIN-код: 1533-6140

ул. Трубецкая, д. 8, стр. 2, Москва 119048

Anna S. Bedenko – Postgraduate, Chair of Nervous Diseases and Neurosurgery

RSCI SPIN-code: 1533-6140

8 bld. 2 Trubetskaya Str., Moscow 119991

mailanna91@yandex.ruhttps://orcid.org/0000-0002-4400-8632АнтоненкоЛ. М.AntonenkoL. M.

Антоненко Людмила Михайловна – д.м.н., профессор кафедры нервных болезней и нейрохирургии

Scopus Author ID: 57220812877; РИНЦ SPIN-код: 2700-0886

ул. Трубецкая, д. 8, стр. 2, Москва 119048

Lyudmila M. Antonenko – Dr. Med. Sc., Professor, Chair of Nervous Diseases and Neurosurgery

Scopus Author ID: 57220812877; RSCI SPIN-code: 2700-0886

8 bld. 2 Trubetskaya Str., Moscow 119991

Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет им. И. М. Сеченова» Министерства здравоохранения Российской ФедерацииРоссияSechenov UniversityRussian Federation202118012022134359366Copyright © Bedenko A.S., Antonenko L.M., 20222022Беденко А.С., Антоненко Л.М.Bedenko A.S., Antonenko L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/750Objective

Objective: to assess vitamin D deficiency and hyperhomocysteinemia along with psychoemotional status in patients with vestibular migraine.

Material and methods

Material and methods. The neurovestibular examination of 23 patients was performed. All patients were diagnosed with vestibular migraine in accordance with the international criteria. The levels of 25-hydroxyvitamin D and homocysteine were assessed by enzyme-linked immunosorbent assay (ELISA). The effect of dizziness on everyday life was assessed according to the Dizziness Handicap Inventory (DHI). Psychoemotional status was investigated for all patients by using the following scales: Beck depression scale, Spilber–Hanin Scale, Toronto Alexithymia Scale (TAS-26).

Results

Results. The mean level of 25-hydroxyvitamin D was 23±15 ng/ml, homocysteine – 11±3.4 μmol/L. The mean levels of situational and personal anxiety were 48.8±9 and 50.4±10.8, respectively. A correlation analysis revealed a significant positive correlation for Beck's depression parameters and DHI score (Spearman's criterion value 0.64, p=0.0016).

Conclusion

Conclusion. The data obtained evidence about a rather frequent detection of 25-hydroxyvitamin D insufficiency and deficit among patients with vestibular migraine that requires further evaluation, including expanding patients sample and/or comparison with other groups of patients. Of significance was to find an elevated level of anxiety and a correlation between the severity of dizziness (according to DHI score) and the level of depression (based on the Beck Scale).

Цель

Цель: оценка уровней 25-гидроксивитамина D, гомоцистеина в плазме крови и психоэмоционального статуса у пациентов с вестибулярной мигренью.

Материал и методы

Материал и методы. Проведено нейровестибулярное обследование 23 пациентов, по результатам которого всем больным установлен диагноз вестибулярной мигрени в соответствии с международными критериями. Уровень 25-гидроксивитамина D и гомоцистеина оценивали методом иммуноферментного анализа. Влияние головокружения на повседневную жизнь определяли по данным шкалы оценки тяжести головокружения (англ. Dizziness Handicap Inventory, DHI). Пациентам проведено исследование психоэмоционального статуса в следующем объеме: шкала депрессии Бека, шкала Спилбергера–Ханина, Торонтская шкала алекситимии (англ. Toronto Alexithymia Scale, TAS-26).

Результаты

Результаты. Средний уровень 25-гидроксивитамина D в плазме крови пациентов составил 23±15 нг/мл, cредний уровень гомоцистеина – 11±3,4 мкмоль/л. Средние уровни ситуативной и личностной тревожности оценены в 48,8±9 баллов и 50,4±10,8 балла соответственно. При проведении корреляционного анализа статистически значимая положительная корреляция была выявлена для показателей оценки по шкале депрессии Бека и шкале DHI (значение критерия Спирмена 0,64, р=0,0016).

Заключение

Заключение. Получены результаты, свидетельствующие о достаточно частом выявлении недостаточности и дефицита 25-гидроксивитамина D в плазме крови у пациентов с вестибулярной мигренью, что требует дальнейшей оценки, в т.ч. раширения выборки и/или сопоставления с другими группами больных. Значимым результатом исследования стало определение повышенного уровня тревоги и корреляции между тяжестью головокружения по данным DHI с уровнем депрессии по шкале Бека.

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The authors declare that there are no conflicts of interest present.