References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2021.100

epilepsia-752

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Posttraumatic epilepsy: clinical, diagnostic and therapeutic features

Посттравматическая эпилепсия: клинические, диагностические и терапевтические особенности

https://orcid.org/0000-0001-6098-9146

Маслов

Н. Е.

Maslov

N. E.

Маслов Никита Евгеньевич – ординатор кафедры лучевой диагностики и медицинской визуализации

РИНЦ SPIN-код: 1422-8694

ул. Аккуратова, д. 2, Санкт-Петербург 197341

Nikita E. Maslov – Resident, Chair of Radiology and Medical Imaging

RSCI SPIN-code: 1422-8694

2 Akkuratov Str., Saint Petersburg 197341

https://orcid.org/0000-0003-2845-9983

Литвинова

А. А.

Litvinova

A. A.

Литвинова Александра Алексеевна – студентка 5-го курса лечебного факультета

Scopus Author ID: 57226671098; РИНЦ SPIN-код: 2234-7591

ул. Крупской, д. 28, Смоленск 214019

Aleksandra A. Litvinova – 5th Year Medical Student, Faculty of General Medicine

Scopus Author ID: 57226671098; RSCI SPIN-code: 2234-7591

28 Krupskaya Str., Smolensk 214019

https://orcid.org/0000-0002-1223-8812

Ковалев

П. С.

Kovalev

P. S.

Ковалев Павел Сергеевич – ассистент кафедры неврологии и нейрохирургии

РИНЦ SPIN-код: 5550-8970

ул. Крупской, д. 28, Смоленск 214019

Pavel S. Kovalev – Assistant Professor, Chair of Neurology and Neurosurgery

RSCI SPIN-code: 5550-8970

28 Krupskaya Str., Smolensk 214019

https://orcid.org/0000-0003-0183-5643

Маслова

Н. Н.

Maslova

N. N.

Маслова Наталья Николаевна – д.м.н., профессор, заведующая кафедрой неврологии и нейрохирургии

Scopus Author ID: 7005487934; РИНЦ SPIN-код: 3051-4884

ул. Крупской, д. 28, Смоленск 214019

Natalia N. Maslova – Dr. Med. Sc., Professor, Chief of Chair of Neurology and Neurosurgery

Scopus Author ID: 7005487934; RSCI SPIN-code: 3051-4884

28 Krupskaya Str., Smolensk 214019

maslovasm@yahoo.com

https://orcid.org/0000-0001-9419-3533

Юрьева

Н. В.

Yuryeva

N. V.

Юрьева Наталья Вячеславовна – к.м.н., доцент кафедры неврологии и нейрохирургии

РИНЦ SPIN-код: 4193-3595

ул. Крупской, д. 28, Смоленск 214019

Natalia V. Yuryeva – MD, PhD, Associate Professor, Chair of Neurology and Neurosurgery

RSCI SPIN-code: 4193-3595

28 Krupskaya Str., Smolensk 214019

https://orcid.org/0000-0002-1986-4621

Хамцова

Е. И.

Khamtsova

E. I.

Хамцова Елена Игоревна – к.м.н., доцент кафедры неврологии и нейрохирургии

РИНЦ SPIN-код: 4091-5210

ул. Крупской, д. 28, Смоленск 214019

Elena I. Khamtsova – MD, PhD, Associate Professor, Chair of Neurology and Neurosurgery

RSCI SPIN-code: 4091-5210

28 Krupskaya Str., Smolensk 214019

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation

Федеральное государственное бюджетное образовательное учреждение высшего образования «Смоленский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSmolensk State Medical UniversityRussian Federation

2021

18012022

134377392

2022

Маслов Н.Е., Литвинова А.А., Ковалев П.С., Маслова Н.Н., Юрьева Н.В., Хамцова Е.И.

Maslov N.E., Litvinova A.A., Kovalev P.S., Maslova N.N., Yuryeva N.V., Khamtsova E.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/752

According to 2019 statistics records, traumatic brain injuries (TBI) are the most common type of injuries and one of the main causes for disability in Russia. Every year 200 people per 10,000 subjects around the world suffer from serious brain injuries. Severe TBI can result in long-term disability. Posttraumatic epilepsy (PTE) is one of the most dramatic consequences of TBI with an estimated incidence rate ranging from 2% to 50% based on severity of injury. Conducting studies on PTE poses numerous challenges because epilepsy never develops in many patients with TBI or it may occur more than 10 years after TBI.

In this review, which includes data from studies conducted by Russian researchers, including us, and foreign colleagues over the last few years (mainly 2017–2022), we analyzed and generalized currently known risk factors, clinical and diagnostic features of PTE in order to increase the awareness about modern methods of laboratory and instrumental diagnostics related to this disease (including electroencephalography and routine/special neuroimaging techniques that allow to identify PTE biomarkers). We also aimed to promote development of preventive strategies for patient management. It has been proved that no clear algorithms for PTE diagnostics and treatment are currently available, which often leads to insufficient patient care.

Согласно статистике на начало 2019 г. черепно-мозговые травмы (ЧМТ) являются наиболее распространенным видом травм и одной из главных причин инвалидизации в России. Ежегодно во всем в мире 200 человек из 10 тыс. получают серьезные травмы головного мозга. Тяжелая ЧМТ может приводить к длительной инвалидности. Посттравматическая эпилепсия (ПТЭ) является одним из наиболее драматичных последствий ЧМТ, частота которого по различным оценкам колеблется от 2% до 50% в зависимости от тяжести травмы. Исследование ПТЭ затруднительно ввиду того, что в ряде случаев может пройти более 10 лет после повреждения, прежде чем начнутся приступы, а у многих пациентов с ЧМТ в анамнезе эпилепсия не развивается вовсе.

В данном обзоре, включающем результаты наших исследований, а также исследований, проведенных российскими и зарубежными коллегами в течение последних лет (приоритетными являлись научные публикации за период 2017– 2021 гг.), осуществлен анализ и обобщение известных на сегодняшний день факторов риска, клинических и диагностических особенностей ПТЭ с целью повышения осведомленности врачей о современных методах лабораторной и инструментальной диагностики данного заболевания (включая электроэнцефалографию и рутинные/специальные методики нейровизуализации, с помощью которых возможна идентификация биомаркеров ПТЭ), а также данных о потенциальных разработке и внедрении в практику профилактических стратегий ведения пациентов. Доказано, что в настоящее время не существует четких алгоритмов превентивной диагностики и лечения ПТЭ, что зачастую приводит к недостаточной помощи пострадавшим.

черепно-мозговая травмапосттравматическая эпилепсиянейровизуализациябиомаркеры

traumatic brain injuryposttraumatic epilepsyneuroimagingbiomarkers

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The authors declare that there are no conflicts of interest present.