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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">epilepsia-76</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>MODERN EPILEPTOLOGY. PROBLEMS AND SOLUTIONS</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННАЯ ЭПИЛЕПТОЛОГИЯ. ПРОБЛЕМЫ И РЕШЕНИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авакян</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Avakyan</surname><given-names>G. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2016</year></pub-date><volume>6</volume><issue>4</issue><fpage>46</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Avakyan G.N., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Авакян Г.Н.</copyright-holder><copyright-holder xml:lang="en">Avakyan G.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/76">https://www.epilepsia.su/jour/article/view/76</self-uri><abstract><p>Abstract: the primary tasks of the current stage in the therapy of epilepsies and epileptic syndromes are: the widespread introduction of new antiepileptic drugs with innovative mechanisms of action on the "target" pathological epileptic systems; the use of new AEDs, not only as additional therapy of drug-resistant epilepsies, but possibly more rapid transition to new forms of drugs at the early stages of ineffective treatment baseline probes.</p></abstract><trans-abstract xml:lang="ru"><p>Первоочередными задачами современного этапа терапии эпилепсий и эпилептических синдромов являются: повсеместное внедрение новых противоэпилептических препаратов с инновационными механизмами действия на «мишени» патологической эпилептической системы; применение новых ПЭП не только в качестве дополнительной терапии фармакорезистентных эпилепсий, но, возможно, более быстрый переход на новые формы препаратов на самых ранних этапах неэффективного лечения базисными ПЭП.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>противоэпилептические препараты</kwd><kwd>инновационные механизмы действия</kwd><kwd>патологическая эпилептическая система</kwd><kwd>фармакорезистентная эпилепсия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antiepileptic drugs</kwd><kwd>innovative mechanisms of action</kwd><kwd>pathological epileptic system</kwd><kwd>drug-resistant epilepsy</kwd><kwd>epilepsy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Авакян Г.Н., Воронина Т.А., Хромых Е.А. 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