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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17749/2077-8333/epi.par.con.2022.109</article-id><article-id custom-type="elpub" pub-id-type="custom">epilepsia-773</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group></article-categories><title-group><article-title>The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech</article-title><trans-title-group xml:lang="ru"><trans-title>Доброкачественные эпилептиформные паттерны детства и их влияние на когнитивные функции, поведение и речь</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3794-215X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозова Елена Александровна – доктор медицинских наук, профессор, заведующая кафедрой детской неврологии.</p><p>ул. Муштари, д. 11, Казань 420012.</p><p>РИНЦ SPIN - код: 7945-2498</p></bio><bio xml:lang="en"><p>Elena А. Morozova – Dr. Med. Sc., Professor, Chief of Chair of Pediatric Neurology, Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional Education.</p><p>11 Mushtari Str., Kazan 420012.</p><p>RSCI SPIN-code: 7945-2498</p></bio><email xlink:type="simple">ratner@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8804-8118</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоусова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belousova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белоусова Марина Владимировна – кандидат медицинских наук, доцент кафедры детской неврологии, доцент кафедры психотерапии и наркологии.</p><p>ул. Муштари, д. 11, Казань 420012.</p><p>РИНЦ SPIN-код: 5883-6113</p></bio><bio xml:lang="en"><p>Marina V. Belousova – MD, PhD, Accociate Professor, Chair of Pediatric Neurology, Accociate Professor, Chair of Psychotherapy and Narcology, Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional Education.</p><p>11 Mushtari Str., Kazan 420012.</p><p>RSCI SPIN-code: 5883-6113</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4389-9143</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозов</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозов Дмитрий Валерьевич – кандидат медицинских наук, доцент кафедры детской неврологии.</p><p>ул. Муштари, д. 11, Казань 420012.</p><p>РИНЦ SPIN-код: 7196-6546</p></bio><bio xml:lang="en"><p>Dmitry V. Morozov – MD, PhD, Accociate Professor, Chair of Pediatric Neurology,  Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional Education.</p><p>11 Mushtari Str., Kazan 420012.</p><p>RSCI SPIN-code: 7196-6546</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7804-372X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уткузова</surname><given-names>М. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Utkuzova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уткузова Марина Анатольевна – кандидат медицинских наук, доцент кафедры детской неврологии.</p><p>ул. Муштари, д. 11, Казань 420012.</p><p>РИНЦ SPIN-код: 9811-0447</p></bio><bio xml:lang="en"><p>Marina A. Utkuzova – MD, PhD, Accociate Professor, Chair of Pediatric Neurology, Kazan State Medical Academy  – branch of Russian Medical Academy of Continuing Professional Education.</p><p>11 Mushtari Str., Kazan 420012.</p><p>RSCI SPIN-code: 9811-0447</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Казанская государственная медицинская академия – филиал федерального государственного бюджетного образовательного учреждения дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical Academy – branch of Russian Medical Academy of Continuing Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>17</day><month>04</month><year>2022</year></pub-date><volume>14</volume><issue>1</issue><fpage>37</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Morozova E.A., Belousova M.V., Morozov D.V., Utkuzova M.A., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Морозова Е.А., Белоусова М.В., Морозов Д.В., Уткузова М.A.</copyright-holder><copyright-holder xml:lang="en">Morozova E.A., Belousova M.V., Morozov D.V., Utkuzova M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/773">https://www.epilepsia.su/jour/article/view/773</self-uri><abstract><p>The article presents a case  report, and a literature review on benign epileptiform  discharges of childhood (BEDC) as well as effect of this type of epileptiform activity on speech, behavior and communication skills are analyzed. The incidence of BEDC comprises 5% in pediatric population.  Examining children with autistic spectrum disorder, BEDC is revealed  in 20% cases, whereas  in those with attention deficit and hyperactivity disorder  (ADHD) or speech  disorder  – in 25% and 18% cases, respectively.  Many studies  considering BEDC as  a  genetic marker of  brain immaturity highlighted by  different level of expressiveness and penetrance are discussed. It is highly probable that cognitive and speech disorders as well as ADHD in children with BEDC may be genetically determined. However, pediatric BEDC may be asymptomatic or become  manifested by diverse psychoneurological symptoms accounted for by developed epileptic encephalopathy and continuous spike and waves during slow wave sleep (CSWS)  requiring specialized long-term treatment. Markedly elevated  CSWS with morphological BEDC affects interneuron connections, which, in turn, alters memory consolidation in mesial temporal regions. The literature analysis  revealed  that children  with BEDC-like epileptic activity require obligatory periodic sleep electroencephalographic control  and dynamic  neuropsychological  evaluation due to  high incidence  of speech, mnestic  and behavioral disorders. Seizure-free BEDC-like epileptic activity should be corrected pharmaceutically only in case  of established  causative link with progressive cognitive impairments.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен  клинический случай, а также проанализированы  литературные данные, касающиеся  доброкачественных эпилептиформных  паттернов детства (ДЭПД) и их влияния на когнитивное и речевое  развитие ребенка, на его поведение и коммуникативную активность. ДЭПД встречаются  у 5% детей в популяции. При обследовании  детей с расстройством  аутистического спектра они выявляются в 20% случаев, при синдроме  дефицита внимания и гиперактивности  (СДВГ) – в 25%, при нарушениях речи – в 18%. Приведены результаты исследований, в которых ДЭПД рассматриваются в качестве генетических маркеров незрелости мозга и различаются по степени экспрессивности и пенетрантности. Когнитивные, речевые расстройства  и СДВГ у детей  с ДЭПД с высокой степенью вероятности генетически детерминированы. При этом клинические проявления могут полностью  отсутствовать  или, наоборот,  дебютировать разнообразной  психоневрологической  симптоматикой, обусловленной  формированием  эпилептической энцефалопатии с продолженной спайк-волновой активностью, которая требует специфического  и длительного лечения. Значительное нарастание индекса эпилептиформной  активности с морфологией ДЭПД во сне приводит к повреждению межнейрональных связей, что, в свою очередь, нарушает процессы  консолидации памяти в структурах мезиальных отделов височной доли. Проведенный анализ показал, что дети с эпилептиформной активностью типа ДЭПД требуют обязательного динамического электроэнцефалографического контроля с включением фрагмента записи во сне и проведением патопсихологического  тестирования в связи с высокой частотой речевых, мнестических и поведенческих расстройств.  Эпилептиформная активность типа ДЭПД, не ассоциированная с приступами, требует медикаментозной коррекции только в случае каузативной связи с прогрессирующими  когнитивными нарушениями пациента.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Доброкачественные эпилептиформные  паттерны детства</kwd><kwd>ДЭПД</kwd><kwd>когнитивные  нарушения</kwd><kwd>синдром дефицита внимания и гиперактивности</kwd><kwd>СДВГ</kwd><kwd>речевые нарушения</kwd><kwd>расстройства  аутистического спектра</kwd><kwd>РАС</kwd><kwd>эпилептическая энцефалопатия</kwd><kwd>врожденное нарушение созревания мозга</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Benign epileptiform discharges of childhood</kwd><kwd>BEDC</kwd><kwd>cognitive impairment</kwd><kwd>attention deficit and hyperactivity disorder</kwd><kwd>ADHD</kwd><kwd>speech disorders</kwd><kwd>autistic spectrum disorders</kwd><kwd>ASD</kwd><kwd>epileptic encephalopathy</kwd><kwd>hereditary impairment of brain maturation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин К.Ю. 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