References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2022.108

epilepsia-777

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Autoimmune epilepsy

Аутоиммунная эпилепсия

https://orcid.org/0000-0003-3149-507X

Шилкина

О. С.

Shilkina

О. S.

Шилкина Ольга Сергеевна – кандидат медицинских наук, невролог.

ул. Карла Маркса, д. 124, Красноярск 660021.

РИНЦ SPIN-код: 1150-7413.

Olga S. Shilkina – MD, PhD, Neurologist, Neurological Center of Epileptology, Neurogenetics and Brain Research, University Clinic, Voino-Yasenetsky Krasnoyarsk State Medical University.

124 Karl Marx Str., Krasnoyarsk 660021.

RSCI SPIN-code: 1150-7413

https://orcid.org/0000-0002-1294-3116

Кантимирова

Е. А.

Kantimirova

E. A.

Кантимирова Елена Анатольевна – кандидат медицинских наук, доцент кафедры медицинской генетики и клинической нейрофизиологии Института профессионального образования.

ул. Партизана Железняка, д. 1, Красноярск 660022.

WoS ResearcherID: AAJ-2986-2020

РИНЦ SPIN-код: 9429-2288

Elena A. Kantimirova – MD, PhD, Associate Professor, Chair of Medical Genetics and Clinical Neurophysiology, Institute of Professional Education, Voino-Yasenetsky Krasnoyarsk State Medical University.

1 Partizan Zheleznyak Str., Krasnoyarsk 660022.

WoS ResearcherID: AAJ-2986-2020

RSCI SPIN-code: 9429-2288

https://orcid.org/0000-0002-9678-6719

Усольцева

А. А.

Usoltseva

A. A.

Усольцева Анна Александровна – аспирант кафедры медицинской генетики и клинической нейрофизиологии Института профессионального образования.

ул. Партизана Железняка, д. 1, Красноярск 660022.

Scopus Author ID: 57210425243

WoS ResearcherID: AAM-9334-2021

РИНЦ SPIN-код: 9163-0862

Anna A. Usoltseva – Postgraduate, Chair of Medical Genetics and Clinical Neurophysiology, Institute of Professional Education, Voino-Yasenetsky Krasnoyarsk State Medical University.

1 Partizan Zheleznyak Str., Krasnoyarsk 660022.

Scopus Author ID: 57210425243

WoS ResearcherID: AAM-9334-2021

RSCI SPIN-code: 9163-0862

a.usoltseva@list.ru

https://orcid.org/0000-0001-8844-0622

Прусова

Т. И.

Prusova

Т. I.

Прусова Татьяна Игоревна – студентка.

ул. Партизана Железняка, д. 1, Красноярск 660022.

Tatiana I. Prusova – Student, Voino-Yasenetsky Krasnoyarsk State Medical University.

1 Partizan Zheleznyak Str., Krasnoyarsk 660022.

https://orcid.org/0000-0003-4639-6365

Дмитренко

Д. В.

Dmitrenko

D. V.

Дмитренко Диана Викторовна – доктор медицинских наук, заведующая кафедрой медицинской генетики и клинической нейрофизиологии Института профессионального образования.

ул. Партизана Железняка, д. 1, Красноярск 660022.

WoS ResearcherID: H-7787-2016

РИНЦ SPIN-код: 9180-6623

Diana V. Dmitrenko – Dr. Med. Sc., Chief of Chair of Medical Genetics and Clinical Neurophysiology, Institute of Professional Education, Voino-Yasenetsky Krasnoyarsk State Medical University.

1 Partizan Zheleznyak Str., Krasnoyarsk 660022.

WoS ResearcherID: H-7787-2016

RSCI SPIN-code: 9180-6623

Неврологический центр эпилептологии, нейрогенетики и исследований мозга Университетской клиники федерального государственного бюджетного образовательного учреждения высшего образования «Красноярский государственный медицинский университет им. Профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияNeurological Center of Epileptology, Neurogenetics and Brain ResearchRussian Federation

Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого Министерства здравоохранения Российской ФедерацииРоссияVoino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation

2022

17042022

1417490

2022

Шилкина О.С., Кантимирова Е.А., Усольцева А.А., Прусова Т.И., Дмитренко Д.В.

Shilkina О.S., Kantimirova E.A., Usoltseva A.A., Prusova Т.I., Dmitrenko D.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/777

Investigation of autoimmune epilepsy (AIE) has been attracting increasingly more attention due to discovery of neuronal antibodies and improved understanding of the mechanisms related to such immune-mediated syndromes. The review is aimed at autoimmune epilepsy taking into account up-to-date advances in exploring its pathophysiology. Definitions related to this issue are outlined, and pathogenetic mechanisms, features of antineuronal antibodies as well as AIE clinical picture based on type of autoantibodies, are considered. The necessity of regular monitoring patients with AIE is indicated, preferably by an epileptologist together with a neuroimmunologist. With prolonged follow-up, chronic pharmacoresistant epilepsy persists in some patients, despite aggressive immunotherapy and antiepileptic drugs. With a deeper understanding of the mechanisms of antibody-mediated and autoantigen-specific T-cell-mediated AIE syndromes, the use of antiepileptic drugs and immunotherapy can be further optimized.

В связи с открытием нейрональных антител и улучшением понимания механизмов этих иммуноопосредованных синдромов все больше внимания уделяется изучению аутоиммунной эпилепсии (АИЭ). Данный обзор посвящен аутоиммунной эпилепсии с учетом последних достижений в области изучения патофизиологии заболевания. Приведены определения, рассмотрены патогенетические механизмы, особенности нейрональных антител и клинической картины АИЭ в зависимости от типа аутоантител. Обоснована необходимость регулярного наблюдения пациентов с АИЭ, предпочтительно эпилептологом совместно с нейроиммунологом. При длительном наблюдении у некоторых больных сохраняется хроническая фармакорезистентная эпилепсия, несмотря на агрессивную иммунотерапию и прием противоэпилептических препаратов. При более глубоком понимании механизмов антителоопосредованных и аутоантигенспецифических Т-клеточно-опосредованных синдромов АИЭ использование противоэпилептических препаратов и иммунотерапии может быть дополнительно оптимизировано.

Аутоиммунная эпилепсиядефиницияпатофизиологиянейрональные антителаклиническая картина

Autoimmune epilepsydefinitionpathophysiologyantineuronal antibodiesclinical picture

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The authors declare that there are no conflicts of interest present.