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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">epilepsia-78</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>UNRESOLVED ISSUES OF INITIAL TREATMENT OF PARTIAL EPILEPSY</article-title><trans-title-group xml:lang="ru"><trans-title>НЕРЕШЕННЫЕ ВОПРОСЫ ИНИЦИАЛЬНОЙ ТЕРАПИИ ПАРЦИАЛЬНОЙ ЭПИЛЕПСИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Липатова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lipatova</surname><given-names>L. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский научно-исследовательский психоневрологический институт имени В. М. Бехтерева</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg V.M. Bekhterev Psychoneurological Research Institute</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2016</year></pub-date><volume>6</volume><issue>4</issue><fpage>55</fpage><lpage>61</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Lipatova L.V., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Липатова Л.В.</copyright-holder><copyright-holder xml:lang="en">Lipatova L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/78">https://www.epilepsia.su/jour/article/view/78</self-uri><abstract><p>Abstract: the selection principles for antiepileptic drugs choice for the initial treatment of partial seizures in epileptic patients with newly diagnosed or untreated epilepsy are discussed; evidence-based criteria and opportunities of the personalized therapy of AED therapy are argued in the review.</p></abstract><trans-abstract xml:lang="ru"><p>В статье обсуждаются критерии выбора антиэпилептических препаратов (АЭП) для инициальной терапии парциальных припадков у больных с впервые выявленной или нелеченой эпилепсией, рассматриваются критерии доказательности эффективности АЭП, возможности персонализированного подбора противоэпилептической терапии.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>парциальные припадки</kwd><kwd>инициальная терапия</kwd><kwd>эффективность</kwd><kwd>безопасность</kwd><kwd>персонифицированная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>partial seizures</kwd><kwd>initial treatment</kwd><kwd>effectiveness</kwd><kwd>safeness</kwd><kwd>personalized therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Власов П.Н., Орехова Н.В., Леонова М.В. 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