epilepsiaEpilepsy and paroxysmal conditionsЭпилепсия и пароксизмальные состояния2077-83332311-4088IRBIS LLCepilepsia-80Research ArticleORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИTHE BASIC REGULATOR OF THE CIRCADIAN SYSTEM IN EPILEPSYИЗУЧЕНИЕ ОСНОВНОГО РЕГУЛЯТОРА ЦИРКАДИАННОЙ СИСТЕМЫ ПРИ ЭПИЛЕПСИИАвакянГ. Н.AvakyanG. N.ОлейниковаО. М.OleinikovaO. M.КареваЕ. Н.KarevaE. N.БогомазоваМ. А.BogomazovaM. A.Российский национальный исследовательский медицинский университет имени Н. И. Пирогова, МоскваРоссияPirogov Russian National Research Medical University, MoscowRussian Federation201403062016646771Copyright © Avakyan G.N., Oleinikova O.M., Kareva E.N., Bogomazova M.A., 20162016Авакян Г.Н., Олейникова О.М., Карева Е.Н., Богомазова М.А.Avakyan G.N., Oleinikova O.M., Kareva E.N., Bogomazova M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.epilepsia.su/jour/article/view/80

Abstract: there were significant increase in the values of the evening melatonin excretion in the spring of the year compared to the autumn. In patients with epilepsy, nocturnal seizures, nocturnal melatonin excretion two times lower than in patients with daytime seizures. In the spring, the evening excretion increased COMT 6; concentration morning urinary 6-COMT higher with anticonvulsant therapy with valproic acid compared with carbamazepine.

Выявлен достоверный рост значений вечерней экскреции мелатонина в весеннее время года по сравнению с осенним. У пациентов с ночными эпилептическими припадками ночная экскреция мелатонина в два раза ниже, чем у пациентов с дневными припадками. В весеннее время года вечерняя экскреция 6 СОМТ увеличивается; концентрация утреннего уринарного 6-СОМТ выше на фоне противосудорожной терапии препаратами вальпроевой кислоты по сравнению с карбамазепином.

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The authors declare that there are no conflicts of interest present.