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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">epilepsia</journal-id><journal-title-group><journal-title xml:lang="en">Epilepsy and paroxysmal conditions</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпилепсия и пароксизмальные состояния</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2077-8333</issn><issn pub-type="epub">2311-4088</issn><publisher><publisher-name>IRBIS LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">epilepsia-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group></article-categories><title-group><article-title>QUESTIONS MODERN EPILEPTOLOGY</article-title><trans-title-group xml:lang="ru"><trans-title>ВОПРОСЫ СОВРЕМЕННОЙ ЭПИЛЕПТОЛОГИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авакян</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Avakyan</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Авакян Гагик Норайрович – доктор медицинских наук, заслуженный деятель науки РФ, профессор кафедры неврологии, нейрохирургии и медицинской генетики ГБОУ ВПО РНИМУ им. Н.И. Пирогова.</p><p>Адрес: ул. Островитянова, д. 1, Москва, Россия, 117997</p></bio><bio xml:lang="en"><p>Avakyan Gagik Norairovich – MD, Honored Scientist of Russia, Professor of Neurology, Neurosurgery and Medical Genetics.  </p><p>Address: ul. Ostrovityanova 1, Moscow, Russia, 117997.</p></bio><email xlink:type="simple">gavakyan@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>30</day><month>05</month><year>2016</year></pub-date><volume>7</volume><issue>4</issue><fpage>16</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Avakyan G.N., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Авакян Г.Н.</copyright-holder><copyright-holder xml:lang="en">Avakyan G.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.epilepsia.su/jour/article/view/9">https://www.epilepsia.su/jour/article/view/9</self-uri><abstract/><trans-abstract xml:lang="ru"><p>Последние эпидемиологические исследования в 16 субъектах Российской Федерации показали, что приступы у больных эпилепсией отсутствовали только у 14,93% пациентов. Менее 5% пациентов получали «новые» противоэпилептические препараты (ПЭП). Во многих случаях препараты назначались в дозах, ниже терапевтических. Отсюда необходимость оптимизации лечения, поиска новых технологий и ПЭП для лечения фармакорезистентных эпилепсий. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>эпидемиологические исследования</kwd><kwd>противоэпилептические препараты</kwd><kwd>фармакорезистентные эпилепсии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>epidemiological studies</kwd><kwd>antiepileptic drugs</kwd><kwd>drug-resistant epilepsy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Авакян Г.Н., Воронина Т.А., Хромых Е.А. Эпилепсии. Патогенез. Патогенетическая терапия. Пособие для врачей. М. 2007; 148 с.</mixed-citation><mixed-citation xml:lang="en">Avakyan G.N., Voronina T.A., Khromykh E.A. Epilepsy. Pathogenesis. Pathogenetic therapy. 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