References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2023.130

epilepsia-906

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Diagnosis and treatment-related issues of autoimmune epilepsy

Проблемы диагностики и лечения аутоиммунной эпилепсии

https://orcid.org/0000-0003-3149-507X

Шилкина

О. С.

Shilkina

O. S.

Шилкина Ольга Сергеевна – к.м.н., невролог Неврологического центра эпилептологии, нейрогенетики и исследований мозга Университетской клиники

ул. Партизана Железняка, д. 1, Красноярск, 660022

Olga S. Shilkina – MD, PhD, Neurologist, Neurological Center of Epileptology, Neurogenetics and Brain Research, University Clinic

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0000-0002-4555-7457

Тимечко

Е. Е.

Timechko

E. E.

Тимечко Елена Евгеньевна – младший научный сотрудник лаборатории медицинской генетики центра коллективного пользования «Молекулярные и клеточные технологии»

WoS ResearcherID: CAF-2677-2022

ул. Партизана Железняка, д. 1, Красноярск, 660022

Elena E. Timechko – Junior Researcher, Laboratory of Medical Genetics, Center of Collective Usage “Molecular and Cellular Technologies”

WoS ResearcherID: CAF-2677-2022

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

https://orcid.org/0000-0003-4639-6365

Дмитренко

Д. В.

Dmitrenko

D. V.

Дмитренко Диана Викторовна – д.м.н., заведующая кафедрой медицинской генетики и клинической нейрофизиологии Института профессионального образования

WoS ResearcherID: H-7787-2016

ул. Партизана Железняка, д. 1, Красноярск, 660022

Diana V. Dmitrenko – Dr. Med. Sc., Chief of Chair of Medical Genetics and Clinical Neurophysiology, Institute of Professional Education

WoS ResearcherID: H-7787-2016

1 Partizan Zheleznyak Str., Krasnoyarsk 660022

mart2802@yandex.ru

Федеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияVoino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation

2023

09072023

152

135–147

2023

Шилкина О.С., Тимечко Е.Е., Дмитренко Д.В.

Shilkina O.S., Timechko E.E., Dmitrenko D.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/906

Due to elevated frequency of autoimmune epilepsy cases, the issues related to reliable clinical and laboratory-instrumental criteria for establishing the disease etiology become relevant. Differentiated assessment of autoantibody markers allows to choose the most effective tactics for managing patients. The article presents the criteria for assessing autoimmune epilepsy as well as diagnostic scales, features related to clinical picture and response to therapy based on the type of synthesized autoantibodies. Therapeutic lines and targets for immunomodulatory and antiepileptic drugs used in autoimmune epilepsy are detailed, the knowledge of which along with clinical and laboratory data collectively allow to determine effective and safe therapy algorithm.

В связи с ростом частоты случаев аутоиммунной эпилепсии актуальным становится вопрос о достоверных клинических и лабораторно-инструментальных критериях, позволяющих установить этиологию заболевания. Дифференцированное определение маркеров-аутоантител дает возможность выбрать наиболее эффективную тактику ведения пациентов. В статье приведены критерии заболевания и диагностические шкалы, представлены особенности клинической картины и ответа на терапию в зависимости от типа синтезируемых аутоантител. Подробно рассматриваются терапевтические линии и точки приложения иммуномодулирующих и противоэпилептических препаратов, применяемых при аутоиммунной эпилепсии, знание которых в совокупности с клинико-лабораторными данными позволяет определить эффективный и безопасный алгоритм терапии.

Аутоиммунная эпилепсиянейрональные антителавысокодозные иммуноглобулиныкортикостероидымоноклональные антитела

Autoimmune epilepsyantineuronal antibodieshigh-dose immunoglobulinscorticosteroidsmonoclonal antibodies

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The authors declare that there are no conflicts of interest present.