References

epilepsia

Epilepsy and paroxysmal conditions

Эпилепсия и пароксизмальные состояния

2077-83332311-4088

IRBIS LLC

10.17749/2077-8333/epi.par.con.2024.176

epilepsia-997

Research Article

SCIENTIFIC SURVEYS

НАУЧНЫЕ ОБЗОРЫ

Cognitive impairment in childhood-onset epilepsy

Когнитивные нарушения при эпилепсии с дебютом в детском возрасте

https://orcid.org/0000-0002-9394-2413

Парамонова

А. И.

Paramonova

A. I.

Парамонова Анастасия Ивановна – аспирант кафедры медицинской генетики и клинической нейрофизиологии Института последипломного образования

ул. Партизана Железняка, д. 1, Красноярск 660022, Россия

WoS ResearcherID: HMP-3496-2023

Anastasia I. Paramonova – Postgraduate, Chair of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education

1 Partizan Zheleznyak Str., Krasnoyarsk 660022, Russia

WoS ResearcherID: HMP-3496-2023

korolek_xd@bk.ru

https://orcid.org/0000-0002-2728-5830

Лысова

К. Д.

Lysova

K. D.

Лысова Кристина Дмитриевна – ассистент кафедры медицинской генетики и клинической нейрофизиологии Института последипломного образования

ул. Партизана Железняка, д. 1, Красноярск 660022, Россия

Kristina D. Lysova – Assistant Professor, Chair of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education

1 Partizan Zheleznyak Str., Krasnoyarsk 660022, Russia

https://orcid.org/0000-0002-4555-7457

Тимечко

Е. Е.

Timechko

E. E.

Тимечко Елена Евгеньевна – младший научный сотрудник лаборатории медицинской генетики центра коллективного пользования «Молекулярные и клеточные технологии»

ул. Партизана Железняка, д. 1, Красноярск 660022, Россия

WoS ResearcherID: CAF-2677-2022

Elena E. Timechko – Junior Researcher, Laboratory of Medical Genetics, Center for Collective Use “Molecular and Cellular Technologies”

1 Partizan Zheleznyak Str., Krasnoyarsk 660022, Russia

WoS ResearcherID: CAF-2677-2022

https://orcid.org/0000-0002-1920-0710

Сенченко

Г. В.

Senchenko

G. V.

Сенченко Галина Васильевна – старший преподаватель кафедры клинической психологии и педагогики с курсом последипломного образования

ул. Партизана Железняка, д. 1, Красноярск 660022, Россия

WoS ResearcherID: AAO-2210-2020

Galina V. Senchenko – Senior Lecturer, Chair of Clinical Psychology and Pedagogy with a Course of Postgraduate Education

1 Partizan Zheleznyak Str., Krasnoyarsk 660022, Russia

WoS ResearcherID: AAO-2210-2020

https://orcid.org/0000-0003-4406-1780

Сапронова

М. Р.

Sapronova

M. R.

Сапронова Маргарита Рафаильевна – к.м.н., доцент кафедры медицинской генетики и клинической нейрофизиологии Института последипломного образования

ул. Партизана Железняка, д. 1, Красноярск 660022, Россия

WoS ResearcherID: AAJ-2507-2020

Margarita R. Sapronova – MD, PhD, Associate Professor, Chair of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education

1 Partizan Zheleznyak Str., Krasnoyarsk 660022, Russia

WoS ResearcherID: AAJ-2507-2020

https://orcid.org/0000-0003-4639-6365

Дмитренко

Д. В.

Dmitrenko

D. V.

Дмитренко Диана Викторовна – д.м.н., заведующая кафедрой медицинской генетики и клинической нейрофизиологии Института последипломного образования

ул. Партизана Железняка, д. 1, Красноярск 660022, Россия

WoS ResearcherID: H-7787-2016

Diana V. Dmitrenko – Dr. Med. Sc., Chief of Chair of Medical Genetics and Clinical Neurophysiology, Institute of Postgraduate Education

1 Partizan Zheleznyak Str., Krasnoyarsk 660022, Russia

WoS ResearcherID: H-7787-2016

Федеральное государственное бюджетное образовательное учреждение высшего образования «Красноярский государственный медицинский университет им. профессора В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской ФедерацииРоссияVoino-Yasenetsky Krasnoyarsk State Medical UniversityRussian Federation

2024

16042024

1615468

2024

Парамонова А.И., Лысова К.Д., Тимечко Е.Е., Сенченко Г.В., Сапронова М.Р., Дмитренко Д.В.

Paramonova A.I., Lysova K.D., Timechko E.E., Senchenko G.V., Sapronova M.R., Dmitrenko D.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.epilepsia.su/jour/article/view/997

In pediatric practice, epilepsy holds one of the leading places among neurological pathologies. Along with seizures, a child's intellectual impairment lowering quality of life plays a crucial role in social disintegration. Cognitive impairments occuring in idiopathic generalized epilepsies (IGE) and self-limited epilepsy with centrotemporal spikes (SeLECTS) considered benign have been widely investigated. However, available data suggest that such disorders result in multiple persistent alterations in the cognitive sphere. In this case, features of the epilepsy etiopathogenesis account for disease early onset and profoundly remodeled structures involved in the implementation of cognitive functions. Current review is aimed to summarizing data regarding developmental mechanisms and range of cognitive impairment in IGE and SeLECTS.

Эпилепсия занимает одну из лидирующих позиций в структуре детской неврологической патологии. Наряду с приступами значительную роль в социальной дезинтеграции играют нарушения различных составляющих интеллекта ребенка. Широко исследуются когнитивные дисфункции, возникающие при идиопатических генерализованных эпилепсиях (ИГЭ) и самокупирующейся эпилепсии с центротемпоральными спайками (англ. self-limited epilepsy with centrotemporal spikes, SeLECTS). Эти формы позиционируются как доброкачественные, однако данные литературы указывают на стойкие множественные изменения когнитивной сферы у таких пациентов. Особенности этиопатогенеза эпилепсии в подобных случаях обусловливают раннее начало и глубокие перестройки структур, участвующих в реализации когнитивных функций. Представленный обзор посвящен обобщению информации о механизмах развития и спектре когнитивных нарушений при ИГЭ и SeLECTS.

Эпилепсия детского возрастаидиопатическая генерализованная эпилепсияИГЭсамокупирующаяся эпилепсия с центротемпоральными спайкамиSeLECTSкогнитивные нарушениякогнитивные функции

Сhildhood epilepsyidiopathic generalized epilepsyIGEself-limited epilepsy with centrotemporal spikesSeLECTScognitive impairmentcognitive functions

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The authors declare that there are no conflicts of interest present.