MELATONIN AND EPILEPSY: ANALYSIS OF INFLUENCE OF PLANETARY GEOMAGNETIC FACTORS
Abstract
Objective. Influence of a solar eclipse known as "Russian", phases of the moon (full moons-new moons) on the maintenance of urinary 6 Sulfatoximelatonine (SOM) in patients with focal epilepsy and healthy is studied.
Materials and Methods. 20 patients with focal epilepsy are examined: 10 during the periods of full moons and new moons – the 1st group; 10 patients with focal epilepsy (the 2nd group) and 12 healthy (the 3rd group) in the period of a solar eclipse. Concentration of the main metabolite of melatonin – a 6-Sulfatoksimelatonin (6-COM) was studied in evening and night time by an immunofermental method by means of Buhlmann 6-Sulfatoxymelatonin ELISA test system (Switzerland).
Results. The night urinary excretion 6-СОМ was higher during the new moon compared to full moon 10006.5+1272 and 6421.8 +2421.7 ng, respectively. Received reliable effect of solar Eclipse on excretion night 6 SOM. During the Eclipse, compared to the next day, evening 6 SOM excretion was lower in healthy – 1.46, patients with epilepsy – in 2.47 times. Changes in morning excretion of 6 SOM were the opposite in nature: increased in the period of the Eclipse compared to the next day in healthy (28%) and epilepsy patients (27%).
Conclusion. Obtained data open perspective correction of disorders melatonin status to eliminate the negative influence of the planetary geomagnetic factors.
About the Authors
O. M. Oleinikova
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
Oleinikova Ol'ga Mikhailovna – PhD, associate Professor of Department Neurology, Neurosurgery and Medical Genetics.
Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997.
E. N. Kareva
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
Kareva Elena Nikolayevna – MD, Professor of Department Pharmacology and molecular radiobiology MBF.
Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997.
G. G. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
Avakyan George Gagikovich – PhD, assistant Professor of Department Neurology, Neurosurgery and Medical Genetics.
Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997.
M. A. Bogomazova
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
Bogomazov, Maria Alexandrovna – senior laboratory assistant of Department Neurology, neurosurgery and medical genetics.
Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997.
G. N. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
Avakyan Gagik Norairovich – MD, Honored Scientist of Russia, Professor of Department Neurology, Neurosurgery and Medical Genetics.
Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997.
References
1. Avakyan G.N., Oleinikova O.M., Kareva E.N., Bogomazova M.A. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2014; 4: 67-71.
2. Avakyan G.N., Oleinikova O.M., Kareva E.N., Bogomazova M.A., Avakyan G.G., Lagutin Yu.V., Sarkisyan K.V., Delger L.B. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2013; 4: 39-40.
3. Vodolazhskaya M.G., Beier E.V. Fiziol. zhurn. 2001; 87 (2): 70-81.
4. Galizdra S.V., Zen'kov M.L., Ganzin I.V. Vestnik Ukrainy. 2009; 13 (3): 48.
5. Dubrov A.P. Lunar rhythms in humans [Lunnye ritmy u cheloveka (in Russian)]. Moscow. 1990; 160 s.
6. Oleinikova O. M., Kareva E.N., Bogomazova M.A., Avakyan G.G., Lagutin Yu.V., Avakyan G.N. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2011; 4: 22-27.
7. Romanov Yu.A. Chronobiology as one of the most important areas of modern theoretical biology. Chronobiology and chronomedicine [Khronobiologiya kak odno iz vazhneishikh napravlenii sovremennoi teoreticheskoi biologii. Khronobiologiya i khronomeditsina (in Russian)]. Moscow. 2000; 488 s.
8. Tananakina E.N. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2014; 3: 31-38.
9. Chizhevskii A.A. Earth echo of solar storms [Zemnoe ekho solnechnykh bur' (in Russian)]. Moscow. 1976; 398 s.
10. Ulashchik V.S. Meditsinskie novosti. 1996; 2: 2-8.
11. Anisimov V.N. Effect of melatonin on life span and longevity. In: Melatonin: Biological Basis of Its Function in Health and Disease / S.R. Pandi-Perumal, D.P. Cardinali, eds. Georgetown, TX: Landes Bioscience. 2006; 45-59.
12. Bhattacharjee Sh., Bradley P., Smith M., Scally A.J., Wilson B.J. Do animals bite more during a full moon? Retrospective observational analysis. Br. Med. J. 2000; 23: 15591561.
13. Cunningham D. The Moon in Your Life: Being a Lunar Type in a Solar World. Weiser Books. Newburyport. 1996; 384.
14. Lieber A.L. How the Moon Affects You. Hastings House. Mamaroneck. NY. 1996; 191.
15. Locher W., Faedler M. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs.VI Seasonal influences on maximal electrochock and PTZ seizure thresholds. Epilepsy Res. 1996; 25 (1): 3-10.
16. Quigg.M. Sircadian rhythms: interactions with seizure and epilepsy. Epilepsy Res. 2000; 42: 43-55.
17. Quigg M., Fowler A.M., Herzog A.G. Circalunar and ultralunar periodicities in women with partial seizures. Epilepsia. 2008; 49 (6): 1081-1085.
18. Rajaram M., Mitra S. Correlation between convulsive seizure and geomagnetic activity. Neurosci Lett. 1981; 24 (2): 187-91.
19. Ribeiro A.S., Felgueira R.M., Guilhoto L.M.F. Seasonal presentation of epileptic seizures in a community. Epilepsia. 2005; 4 (6): 244.
20. Torshin V.I., Vlasova I.G. Biorhythmologic aspects of seizure activity. Bull Exp Biol Med. 2001; 132 (50): 1025-1028.
21. Waterhouse E. Status epilepticus in acute setting. Epilepsy Curr. 2002; 2 (2): 43-44.
Review
For citations:
Oleinikova O.M., Kareva E.N., Avakyan G.G., Bogomazova M.A., Avakyan G.N. MELATONIN AND EPILEPSY: ANALYSIS OF INFLUENCE OF PLANETARY GEOMAGNETIC FACTORS. Epilepsy and paroxysmal conditions. 2015;7(4):29-34. (In Russ.)
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