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CLINICAL AND ELECTROENCEPHALOGRAPHIC SEMIOLOGY OF MYOCLONIC-ATONIC SEIZURES

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Abstract

Abstract: myoclonic-atonic seizures (MAS) – short epileptic generalized seizures in the form of sudden falling spells (or drop attacks). Inour study were vealed MAS in 1.3% of all cases of epilepsy with onset of seizures before 18 years old (n=1261). Predominance of man among the patients was revealed (76.5% men versus 23.5% woman). The most often in the patients with MAS myoclonic-astatic epilepsy (MAE) was diagnosed – 41,2% of cases. Symptomatic and cryptogenic forms of focal epilepsy were diagnosed in 35.2% of the patients. Lennox-Gastaut syndrome was revealed in 23.6% of cases. Onset of epilepsy with MAS varied widely – from 9 month to 6 year soflife; middle age of onset was 3.4 years±1.28 years. In all the cases MAS occurred in combination with other types of seizures: there can be any of 9 differenttypes of seizures. The most often myoclonic seizures (70.6% of cases), generalized convulsive seizures (47.1%) and absences (47.1%) were registered. Remission was achieved in 64.7% cases of epilepsy, associated with MAS. Reduction of seizure frequency ≥50% on antiepileptic treatment was achieved in 29.4% of the patients. Only in one patient (5.9%) the therapy was not effective. Our study demonstrated different efficacyof antiepileptic drugs in the treatment of different epileptic syndromes, associated with MAS.

About the Authors

M. B. Mironov
Институт детской неврологии и эпилепсии имени Святителя Луки, Москва
Russian Federation


K. Yu. Mukhin
Институт детской неврологии и эпилепсии имени Святителя Луки, Москва
Russian Federation


T. M. Krasilschikova
Pirogov Russian National Research Medical University, Moscow
Russian Federation


A. F. Dolinina
Областная клиническая детская больница, Челябинск
Russian Federation


A. S. Petrukhin
Pirogov Russian National Research Medical University, Moscow
Russian Federation


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For citation:


Mironov M.B., Mukhin K.Yu., Krasilschikova T.M., Dolinina A.F., Petrukhin A.S. CLINICAL AND ELECTROENCEPHALOGRAPHIC SEMIOLOGY OF MYOCLONIC-ATONIC SEIZURES. Epilepsy and paroxysmal conditions. 2013;5(3):24-33. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)