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AGE-DEPENDING EFFICIENCY AND SAFETY OF TOPIRAMATE IN PATIENTS WITH DIFFERENT FORMS OF EPILEPSY

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Abstract

Abstract: the aim of the study was to analyst the efficiency and safety of topiramate in children and adult epileptic populations depending on the patient’s age and forms of epilepsy. 597 epileptic patients receiving topiramate (302 males, 295 females) aged from 2 up 57 years were followed with video-EEG control during the period of 2002-2012. Topiramate was effective at 66,2% of patients (n=395). Low efficiency was seen at 26,8% (n=160) patients. The aggravation effect has been noted at 7% (n=42) of patients. Drug compliance (for >1 year) was 61,8% (n=369). High efficiency in group 2-3 year (n=134) was 53,8% (n=72), low efficiency in 34,3% (n=46), aggravation – in 11,9% cases (n=16); in group >3-7 years (n=253) high efficiency 59,7% (n=151), low 32% (n=81), aggravation in 8,3% (n=21); in pediatric population >7 years (n=132) high efficiency 81,8% (n=108), low effect in 15,2% (n=20), and 3% aggravation (n=4); in adult population >18 years (n=78) the efficiency was 82,1% (n=64), low effect 16,6% (n=13) and aggravation in 1,3% (n=1). So, topiramate is highly effective medication in the therapy of idiopathic generalized epilepsies without absences and in symptomatic/cryptogenic focal forms of epilepsy. Topiramate could also be useful additional drug in the therapy of epileptic encephalopathies. With the increasing of patients’ age the efficiency of topiramate raised, while the aggravation risks decreased. Peak of aggravation potential was seen in early childhood population and maximal effectiveness – in children up 7 years and adult population.

About the Authors

A. A. Kholin
Pirogov Russian National Research Medical University, Moscow; Russian Children’s Clinical Hospital of the Ministry of Health, Moscow
Russian Federation


N. N. Zavadenko
Pirogov Russian National Research Medical University, Moscow
Russian Federation


E. S. Il'ina
Russian Children’s Clinical Hospital of the Ministry of Health, Moscow
Russian Federation


I. D. Fedonyuk
Russian Children’s Clinical Hospital of the Ministry of Health, Moscow
Russian Federation


L. M. Kolpakchi
Russian Children’s Clinical Hospital of the Ministry of Health, Moscow
Russian Federation


V. S. Khalilov
Pirogov Russian National Research Medical University, Moscow
Russian Federation


E. S. Kosyakova
Pirogov Russian National Research Medical University, Moscow
Russian Federation


References

1. Балакирева Е.А., Неретина А.Ф., Иващенко О.В. Опыт применения топамакса в лечении эпилепсии у детей раннего возраста. Русский журнал детской неврологии. 2008; III (4): 3-7.

2. Бурд С.Г. Роль топирамата в лечении эпилепсии. Эпилепсия и пароксизмальные состояния. 2012; 1: 34-39.

3. Гехт А.Б., Мильчакова Л.Е., Гусев Е.И. Опыт применения Топамакса: клинические и фармакоэкономические аспекты. Журнал неврологии и психиатрии им. С.С. Корсакова. 2005; 107 (12): 40-44.

4. Дорофеева М.Ю., Ермаков А.Ю., Белоусова Е.Д. Эффективность топирамата (топамакса) в лечении резистентной эпилепсии у детей. Журнал неврологии и психиатрии им. С.С. Корсакова. 2005; 105 (11): 21-23.

5. Карлов В.А., Фрейдкова Н.В., Русанова Л.В., Жидкова И.А., Поленова Ю.М. Оценка эффективности Топамакса (Топирамата) при длительной терапии фокальных эпилепсий. Эпилепсия и пароксизмальные состояния. 2011; 4: 54-55.

6. Мухин К.Ю., Глухова Л.Ю., Петрухин А.С., Миронов М.Б., Соборнова А.М. Топамакс при монотерапии эпилепсии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2004; 104 (8): 35-40.

7. Мухин К.Ю., Тысячина М.Д., Мухина Л.Н., Петрухин А.С. Сравнительная эффективность и переносимость топирамата, вальпроатов и карбамазепина в монотерапии эпилепсии у детей и молодых взрослых. Русский журнал детской неврологии. 2008; III (2): 3-48.

8. Сивкова С.Н., Прусаков В.Ф., Зайкова Ф.М. Топирамат в лечении эпилепсии у детей раннего возраста. Русский журнал детской неврологии. 2008; III (4): 7-16.

9. Фрейдкова Н.В. Опыт применение топирамата в капсулах у детей. Эпилепсия и пароксизмальные состояния. 2010; 2: 39-41.

10. Glauser T.A., Dlugos D.J., Dodson W.E., Grinspan A., Wang S., Wu S.C.; EPMN-106/INT-28 Investigators. Topiramate monotherapy in newly diagnosed epilepsy in children and adolescents. J. Child Neurol. 2007; 22 (6): 693-9.

11. Guerrini R., Carpay J., Groselj J., van Oene J., Schreiner A., Lahaye M., Schwalen S.; TOP-INT-51 Investigators Group. Topiramate monotherapy as broad-spectrum antiepileptic drug in a naturalistic clinical setting. Seizure. 2005; 14 (6): 371-80.

12. Labate A., Siniscalchi A., Mumoli L., Aguglia U., Quattrone A., Gambardella A. Topiramate and temporal lobe epilepsy: an open-label study. Epileptic Disord. 2012; 14 (2): 163-6.

13. Puri V., Ness S., Sattaluri S.J., Wang S., Todd M., Yuen E., Eerdekens M., Nye J.S., Manitpisitkul P., Shalayda K., Ford L. Long-term open-label study of adjunctive topiramate in infants with refractory partial-onset seizures. J. Child Neurol. 2011; 26 (10): 1271-83.

14. Valencia I., Fons C., Kothare S.V., Khurana D.S., Yum S., Hardison H.H., Legido A. Efficacy and tolerability of topiramate in children younger than 2 years old. J. Child Neurol. 2005; 20 (8): 667-9.


For citation:


Kholin A.A., Zavadenko N.N., Il'ina E.S., Fedonyuk I.D., Kolpakchi L.M., Khalilov V.S., Kosyakova E.S. AGE-DEPENDING EFFICIENCY AND SAFETY OF TOPIRAMATE IN PATIENTS WITH DIFFERENT FORMS OF EPILEPSY. Epilepsy and paroxysmal conditions. 2013;5(3):34-40. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)