Epilepsy and paroxysmal conditions

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Hypoglycemia in congenital hyperinsulinism (WGI) in children increases the risk of brain damage, seizures and development delay. The aim of our study was to evaluate the clinical manifestations in children with CHI. Hypoglycemia is often manifests with seizures, which are sometimes in the future may lead to the development of epilepsy. Seizures in CHI do not always require a diagnosis of epilepsy and prescription of anticonvulsants. EEG changes in these children may be observed in the absence of epileptic seizures. Developmental delay was more common in children with neurological abnormalities and MRI changes. Children with ABCC8 gene mutations have more complicated for CHI and more prominent developmental delay. 

About the Authors

I. O. Shchederkina
Morozov Children’s Clinical Hospital, Moscow; Pirogov Russian National Research Medical University, Moscow
Russian Federation

Shсhederkina Inna Olegovna – PhD, neurologist, head of neurological Cabinet for children with organic CNS and Mental Disorders Advisory Center Morozov Children’s Clinical Hospital, docent, Neurology, Neurosurgery and Medical Genetics Depertment, Pirogov Russian National Research Medical University.

Address: 4 Dobrininsky per., 1|9, Moscow, Russia, 119037.

M. A. Melikyan
Russian Endocrinology Reaseach Center, Moscow
Russian Federation

Melikyan Maria Armenakovna – PhD, endocrinologist, senior researcher. 

Address: Dmitry Ulyanov, 11, Moscow, Russia, 117036.

A. N. Zavadenko
Morozov Children’s Clinical Hospital, Moscow; Pirogov Russian National Research Medical University, Moscow
Russian Federation

Zavadenko Aleksandra Nikolaevna – PhD, neurologist, assistant of the Neonatology Department. 

Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997.

E. V. Kozlova
Federal scientific clinical center of children hematology, oncology and immunology of D. Rogachov, Moscow ; Morozov Children’s Clinical Hospital, Moscow
Russian Federation

Kozlova Elizaveta Viktorovna – PhD, neurologist.

Address: ul. S. Machel, 1, GSP-7, Moscow, Russia, 117997. 

N. N. Zavadenko
Morozov Children’s Clinical Hospital, Moscow; Pirogov Russian National Research Medical University, Moscow
Russian Federation

Zavadenko Nikolaj Nikolaevich – MD, neurologist, Professor, Head of Department of Neurology, Neurosurgery and Medical Genetics, Pirogov Russian National Research Medical University.

Address: ul. Ostrovityanova, 1, Moscow, Russia, 117997. 


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For citation:

Shchederkina I.O., Melikyan M.A., Zavadenko A.N., Kozlova E.V., Zavadenko N.N. NEUROLOGICAL PAROXYSMAL DISORDERS IN CHILDREN WITH HYPOGLYCEMIA IN CONGENITAL HYPERINSULINISM: POLYMORPHISM OF CLINICAL IMPLICATIONS. Epilepsy and paroxysmal conditions. 2015;7(2):49-58. (In Russ.)

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