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ELECTROPHYSIOLOGICAL MECHANISMS OF ANTIEPILEPTIC ACTIONS REALIZATION OF BEPRODON

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Abstract

The purpose of this research was to study electric and physiological mechanisms of the achievement of the antoconvulsant effect of the new original beprodon combination together with determination of determinant brain structures – therapeutic targets.

Materials and Methods. Partial (focal) and secondary generalized convulsions were generated using the method of creation of a chronic epileptogenic focus, caused by the cobalt application on rats’ brain.

Results: it was revealed, that at the first stage of the epileptic system (ES) beprodone is targeted to cortical focuses, and at the second stage – to subcortical focuses, generating epileptic activities. Conclusion: the beprodone effect depends on the stage of the epileptic system development and is targeted to determinant focuses.

About the Authors

T. A. Voronina
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Voronina Tat'yana Aleksandrovna – professor, MD, head of the Laboratory. 

Address: Baltiiskaya str., 8, Moscow, 125315.



L. N. Nerobkova
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Nerobkova Lyubov' Nikolaevna – Ph.D., Senior Research Fellow. 

Address: Baltiiskaya str., 8, Moscow, 125315.



G. N. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation

Avakyan Gagik Norairovich – MD, Honored Scientist of Russia, Professor of Neurology and Neurosurgery. 

Address: Ostrovityanova str., 1.Moscow. 117997.

 


A. V. Bakhutashvili
Xenova LLC, Moscow
Russian Federation

Bakhutashvili Aleksandr Vladimirovich – Ph.D., General Director. 

Address: Salyama Adilya str., 9, Moscow, 123154.



G. G. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation

Avakyan Georgii Gagikovich – MD, PhD, Department of Neurology, Neurosurgery and Medical Genetics.

Address: Ostrovityanova str., 1.Moscow. 117997



I. G. Kapitsa
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Kapitsa Inga Gennad’evna – PhD, Senior Researcher. 

Address: Baltiiskaya str., 8, Moscow, 125315.



I. O. Gaidukov
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Gaidukov Igor’ Olegovich – Post-graduate. 

Address: Baltiiskaya str., 8, Moscow, 125315.



I. G. Kovalev
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Kovalev Ivan Georgievich – Post-graduate. 

Address: Baltiiskaya str., 8, Moscow, 125315.



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For citation:


Voronina T.A., Nerobkova L.N., Avakyan G.N., Bakhutashvili A.V., Avakyan G.G., Kapitsa I.G., Gaidukov I.O., Kovalev I.G. ELECTROPHYSIOLOGICAL MECHANISMS OF ANTIEPILEPTIC ACTIONS REALIZATION OF BEPRODON. Epilepsia and paroxysmal conditions. 2015;7(1):8-19. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)