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THE MULTIPLE PARAMETER ANALYSIS OF EEG AT PATIENTS WITH RIGHT-HAND LOCALIZATION OF THE EPILEPTIC FOCUS

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Abstract

The article considers the peculiarities of the spatial organization of brain potentials in epileptic patients with a lesion in the right hemisphere. We identified violations of the spatial organization of brain potentials, which allow you to objectify violations of structural-functional relationships in epileptic patients with a lesion in the right hemisphere with the formation of multilevel pathological neural networks involving intact neural populations. Specific changes of hemispheric interactions characterized by a significant decrease in average levels of coherence in the occipital, parietal and anterio temporal areas in most frequency bands. The obtained data allow to suppose the specificity of the changes in alpha activity, characterized by the reciprocity of changes in the alpha rhythm in the range of 9-10 and 11-12 number`s.

About the Authors

L. N. Nerobkova
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Nerobkova Lyubov' Nikolaevna – Ph.D., Senior Research Fellow. 

Address: Baltiiskaya str., 8, Moscow, 125315.

 


T. A. Voronina
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Voronina Tat'yana Aleksandrovna – professor, MD, head of the Laboratory. 

Address: Baltiiskaya str., 8, Moscow, 125315.

 


G. N. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation

Avakyan Gagik Norairovich – MD, Honored Scientist of Russia, Professor of Neurology and Neurosurgery. 

Address: Ostrovityanova str., 1.Moscow. 117997.



G. G. Avakyan
Pirogov Russian National Research Medical University, Moscow
Russian Federation

Avakyan Georgii Gagikovich – MD, PhD, Department of Neurology, Neurosurgery and Medical Genetics.

Address: Ostrovityanova str., 1.Moscow. 117997

 


E. A. Chromich
Pirogov Russian National Research Medical University, Moscow
Russian Federation

Khromykh Elena Aleksandrovna. 

Address: Ostrovityanova str., 1.Moscow. 117997



I. G. Kovalyov
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Kovalev Ivan Georgievich – Post-graduate. 

Address: Baltiiskaya str., 8, Moscow, 125315.

 


I. O. Gaydukov
Institute of Pharmacology named V. V. Zakusov, Moscow
Russian Federation

Gaidukov Igor’ Olegovich – Post-graduate. 

Address: Baltiiskaya str., 8, Moscow, 125315.

 


References

1. Avakyan G.N., Badalyan O.L., Burd S.G., Rider F.K., Voronina T.A., Nerobkova L.N. Neyrodiagnostika i vysokie biomeditsinskie tekhnologii. 2006; 2: 91-96.

2. Avakyan G.N., Denisova S.V. Russkiy meditsinskiy zhurnal. 2008; 16 96): 366-371.

3. Bendat Dzh., Pirsol L. Measurement and analysis of stochastic processes. Translated from English. Preface GY Mirsky [Izmerenie i analiz sluchaynykh protsessov. Perevod s angliyskogo. Predislovie G.Ya. Mirskogo]. Moscow. 1974; 464 s.

4. Bekhtereva N.P., Kambarova D.K., Pozdeev V.K. Sustainable pathological condition in diseases of the brain [Ustoychivoe patologicheskoe sostoyanie pri boleznyakh mozga]. Leningrad. 1978; 240.

5. Boldyreva G.N. The electrical activity of the brain in the defeat dientsifalnyh and limbic structures [Elektricheskaya aktivnost’ mozga pri porazhenii dientsifal’nykh i limbicheskikh struktur]. Moscow. 2000; 181 s.

6. Boldyreva G.N., Manelis N.G., Skoryatina I.G., Frolov A.A. Fiziologiya cheloveka. 1997; 23 (2): 42-49.

7. Boldyreva G.N., Zhavoronkova L.A., Sharova E.V., Dobronravova I.S. Zhurn. vysshey nervnoy deyatel’nosti. 2003; 53 (4): 391-401.

8. Voronina I.A. A method for determining the risk of complications in the early postoperative period in patients after tumor removal basal diencephalic localization patent [RU 2473303]: A61B5 / 0476. Electroencephalography. 2011; [Patent Publication: 27/01/2013] [Sposob opredeleniya riska razvitiya oslozhneniy v rannem posleoperatsionnom periode u bol’nykh posle udaleniya opukholey bazal’nodientsefal’noy lokalizatsii patent [RU 2473303]: A61B5/0476. Elektroentsefalografiya. 2011].

9. Grebenyuk O.V., Rudchenko S.A., Kotov D.V., Kazennykh T.V., Alifirova V.M. A method of detecting epileptiform activity. Patent number 2409315 on 20 January 2011 [Sposob vyyavleniya epileptiformnoy aktivnosti. Patent № 2409315 ot 20.01.2011].

10. Grebenyuk O.V., Alifirova V.M., Svetlik M.V. Sibirskiy vestnik psikhiatrii i narkologii. 2013; 5 (80): 71-76.

11. Gusev E.I, Avakyan G.N., Nerobkova L.N., Dovletkhanova E.R., Oleynikova O.M, Mitrofanov A.A. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2002; 3: 37-42.

12. Karlov V.A. Epilepsy in children and adult women and men [Epilepsiya u detey i vzroslykh zhenshchin i muzhchin]. Moscow. 2010.

13. Korsakova E.A., Khorshev S.K, Barantsevich E.R, Slezin V.B. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011; 5: 37-41.

14. Kryzhanovskiy G.N. Determinant structure in the pathology of the nervous system [Determinantnye struktury v patologii nervnoy sistemy]. Moscow. 1980; 89 s.

15. Kryzhanovskiy G.N. General pathology of the nervous system [Obshchaya patologiya nervnoy sistemy]. Moscow. 1997.

16. Kryzhanovskiy G.N. Dizregulyatsionnaya pathology [Dizregulyatsionnaya patologiya]. Moscow. 2002.

17. Kryzhanovskiy G.N., Shandra A.A., Godlevskiy JI.C., Mazarati A.M. Uspekhi fiziol. nayk. 1992; 23 (3): 38-59.

18. Kurbanova S.A., Oleynikova O.M., Avakyan G.N. Zhurnal nevrologii i psikhiatrii. 2007; 6: 50-53.

19. Morozova M.A., Blagosklonova N.K. Fiziologiya cheloveka. 2007; 4: 18-23.

20. Nerobkova L.N., Filatova Yu.B., Voronina T.A., Avakyan G.G., Khromykh E.A., Gaydukov I.O., Avakyan G.N. Epilepsiya i paroksizmal’nye sostoyaniya. 2013; 5 (1): 22-3.

21. Okudzhava V.M. Basic neurophysiological mechanisms of epileptic activity [Osnovnye neyrofiziologicheskie mekhanizmy epilepticheskoy aktivnosti]. Tbilisi. 1969.

22. Saradzhishvili P.M., Geladze T.Sh. epilepsy [Epilepsiya]. Moscow.1977; 304 s.

23. Stepanova T.S., Grachev K.V. Electrophysiology pathogenetic stereotactic epilepsy. Proceedings of the conference on the problem of epilepsy [Elektrofiziologiya patogeneticheskogo stereotaksisa pri epilepsii. Materialy konferentsii po probleme epilepsii]. Erevan. 1976; 87-91.

24. Gambarelli Y., Gurinel G., Cherrot L., Mattei M. Computerized axial Tomography [an anat. Atlas of sections of the Human body. AnatomyRachiology-Scannes]. Berlin – Heidelbetg – N.Y. 1977.

25. Jinyao Zhang. Nonlinear Analysis and Biomarkers in Neurological Diseases [Temporal Lobe Epilepsy and Alzheimer’s Disease]; http://www.researchgate.net/ publication/3086435.

26. Kramer M.A., Cash S.S. Epilepsy as a disorder of cortical network organization. Neuroscientist. 2012; 18 (4): 360-72.

27. Laufs H. Functional imaging of seizures and epilepsy: evolution from zones to networks. Curr Opin Neurol. 2012; 25: 194-200.

28. Lopes da Silva F., Blanes W., Kalitzin S. N. et al. Epilepsies as dynamical diseases of brain systems: basic models of the transition between normal and epileptic activity. Epilepsia. 2003; 44 (12): 72-8.

29. Rosenow F., Luders H. Presurgical evaluation of epilepsy. Brain. 2001; 124: 1683-1700.

30. Rummel C., Goodfellow M., Gast H. et al. A systems-level approach to human epileptic seizures. Neuroinformatics. 2013; 11: 159-173.

31. Spencer S.S. Neural networks in human epilepsy: evidence of and implications for treatment. Epilepsia. 2002; 43: 219-227.

32. Warren C.P., Hu S., Stead M., Brinkmann B.H., Bower M.R., Worrell G.A. Synchrony in Normal and Focal Epileptic Brain: The Seizure Onset Zone is Functionally Disconnected. J Neurophysiol. 2010; 104: 3530-3539.


For citation:


Nerobkova L.N., Voronina T.A., Avakyan G.N., Avakyan G.G., Chromich E.A., Kovalyov I.G., Gaydukov I.O. THE MULTIPLE PARAMETER ANALYSIS OF EEG AT PATIENTS WITH RIGHT-HAND LOCALIZATION OF THE EPILEPTIC FOCUS. Epilepsy and paroxysmal conditions. 2015;7(1):25-34. (In Russ.)

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ISSN 2311-4088 (Online)