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Epilepsia and paroxysmal conditions

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MIGRAINE AND EPILEPSY

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Abstract

Migraine and epilepsy are comorbid neurological diseases that have common clinical and pathophysiological features, as well as common approaches to their treatment. Existing epilepsy increases the risk of development of migraine by 2.4-fold, while migraine makes development of epilepsy 4.1 times more likely. A combination of migraine and epilepsy aggravates the progression of each of these diseases. The most probable cause of the comorbidity of migraine and epilepsy is the common pathophysiological alterations that result in excessive excitation of neurons in the central nervous system, whereas anticonvulsants, which are effective in the treatment of either of these diseases, decrease neuronal excitation. Understanding of the common pathophysiological mechanisms of migraine and epilepsy broadens the current conception of the mechanisms underlying the symptoms of both diseases and offers a new perspective in their treatment

About the Authors

Yu. E. Azimova
I. M. Sechenov Moscow Medical Academy
Russian Federation
Department of Neurology and Clinical Neurophysiology


G. R. Tabeeva
I. M. Sechenov Moscow Medical Academy
Russian Federation
Department of Neurology and Clinical Neurophysiology


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For citation:


Azimova Y.E., Tabeeva G.R. MIGRAINE AND EPILEPSY. Epilepsia and paroxysmal conditions. 2009;1(1):21-25. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)