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Epilepsy and paroxysmal conditions

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EXPERIENCE OF TOPIRAMATE CAPSULES TREATMENT OF CHILDREN

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Abstract

Treatment of epilepsy, a disease which is high incident and very diverse in terms of clinical forms, in children, is one of the key issues in the pediatric epileptology. New antiepileptic drugs have been developed recently, and special pediatric pharmaceutical forms are being developed, among them - Topiramate capsules. The publication discusses evaluation of two patient groups. Children from group one received topiramate tablets (Topamax®) followed by a switch to the study drug in capsules. Children from group two received topiramate capsules alone or in combination with other treatments from the baseline. The analysis demonstrated bioequivalence of Topamax® tablets and capsules, its high efficacy and good tolerability, as well as convenience of administration in children.

About the Author

N. V. Freidkova
Morozov children clinical hospital, Moscow
Russian Federation


References

1. Топамакс. Инструкция по медицинскому применению препарата. Рег. Номер ПТ 011415/02.

2. Белоусова Е.Д.. Лечение эпилепсии у детей: специальные лекарственные формы. Журнал Эпилепсия и пароксизмальные состояния. 2009. №1.С. 26-30.

3. Ермаков А.Ю., Литвинович Е.Ф.. Детские формы антиэпилептических препаратов. Журнал Медицинский совет. 2009. №1. С 28-32.

4. Калинин В.В., Железнова Е.В., Соколова, Л.В., Земляная А.А. Противосудорожные и психотропные эффекты топамакса в капсулах. Журнал неврология и психиатрия им. С.С. Корсакова.2009. №12. С 80-84.

5. Marsden D, Libretto S. Hypersensitivity to topiramate sprinkles does not preclude the use of topiramate tablets. Paediatr Drugs. 2004; 6 (22): 133-5.

6. Novotry E, Renfroe B, Yardy N. et al. Randomized trial of adjunctive topiramate therapy in infants with refractory partial seizures. Neurology. 2010 Mar 2; 74(9): 714-20.


For citation:


Freidkova N.V. EXPERIENCE OF TOPIRAMATE CAPSULES TREATMENT OF CHILDREN. Epilepsy and paroxysmal conditions. 2010;2(2):39-41. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)