Epilepsy and paroxysmal conditions

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The given work has been undertaken for an estimation of major factors of failure of remission of an epilepsy, and also correlation revealing between duration of disease and risk of relapse. We had been surveyed and analysed 104 patients with an epilepsy, without expressed mental retardation, observed in medical center «Nevromed». From them to the basic group - (relapse presence) has been carried 76 persons, to control group - (without relapse) - 28 patients. The importance of two major factors has been revealed: forms of an epilepsy and current type. The probability of relapse, according to the received results, remains throughout all duration of disease.

About the Authors

V. A. Karlov
Moscow State Medical and Stomatological University
Russian Federation

E. M. Rokotyanskaya
Moscow State Medical and Stomatological University
Russian Federation

G. A. Kovalenko
Moscow State Medical and Stomatological University
Russian Federation


1. Гехт А.Б. Эпидемиология и фармакоэкономические аспекты эпилепсии Журн неврол и психиат 2005; 105:8:63—65.

2. Кальвиайнен Р. Влияние противоэпилептических препаратов на когнитивные функции и поведение при эпилепсии. Эпилептология в медицине XXI века/ Под. Ред. Е.И Гусева, А.Б., Гехт. Москва 2009, 199-204

3. Карлов В.А. Эпилепсия М Медицина 1990.-336с.

4. Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин: руководство для врачей.– М.: Медицина, 2010.– 717с.

5. Котов А.С., Рудакова И.Г., Котов С.В. Роль провоцирующих факторов в развитии эпилептических приступов Эпилептология в медицине XXI века/ Под. Ред. Е.И Гусева, А.Б., Гехт. Москва 2009,89-103

6. Перукка Э Современная стратегия фармакотерапии эпилепсии. Эпилептология в медицине XXI века / Под. Ред. Е.И Гусева, А.Б., Гехт. Москва 2009,359--381.

7. Теплышева А.М. Клинико-нейрофизиологи ческий анализ медикаментознорезистентной парциальной эпилепсии: Дис. ... канд. мед. наук. М 2004.

8. 8) Хабибова А.О. Качество жизни взрослых больных парциальной эпилепсией: Дис. ... канд. мед. наук. М 1998.

9. Berg AT, Shinnar S. Relapse following discontinuation of antiepileptic drugs: a meta-analysis. Neurology 1994;44: 601–608.

10. Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE).Epilepsia.2005;46:470

11. Holmes L.B., Harvey E.A., Coull B.A. et al. The teratogenicity of anticonvulsant drugs. N Engl J Med 2001; 344: 1132-1138

12. Hitiris N, Mohanraj R, Norrie J, Sills GJ, Brodie MJ. Predictors of pharmacoresistant epilepsy. Epilepsy Res. 2007;75:192–196.

13. Jallon P. Epidemiology of epilepsies In Panayiotopoulos C.P., ed. V. 1: A practical guide to childhood epilepsies. Oxford: Medicinae: 2006. 17-20. 14. Kwan, P, Sander, J W. The natural history of epilepsy: an epidemiological view. J. Neurol. Neurosurg. Psychiatry2004; 75: 1376-1381

14. Kwan P,Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000; 342:314–319.

15. Yerby M S. Teratogenicity and antiepileptic drugs: potential mechanisms. Int Rev Neurobiol. 2008;83:181-204

16. Nicoletti A, Sofia V, Vitale G, Bonelli SI, Bejarano V, Bartalesi F, Tran DS, Preux PM, Zappia m, Bartoloni A.The Natural History of Epilepsy: Spontaneous Remission and morta lityEpilepsia2009;50(10):2199–2206

17. Perucca, P., Carter, J., Vahle, V., Gilliam, F. G. Adverse antiepileptic drug effects: Toward a clinically and neurobiologically relevant taxonomy. Neurology2009; 72: 1223-1229

18. Schmidt D, LöscherW. Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure-free patients: a review of current clinicalexperience. Acta Neurol Scand 2005: 111: 291–300.

19. Schiller Y.Seizure relapse and development of drug resistance following long-term seizure remission. Arch Neurol.2009 66(10):1233-9.

20. Sillanpää M, Schmidt D. Natural history of treated childhood-onset epilepsy: prospective, long-term population-based study. Brain 2006;129:617–24

For citation:

Karlov V.A., Rokotyanskaya E.M., Kovalenko G.A. ISSUES OF RELAPSES IN ADULT PATIENTS WITH EPILEPSY. Epilepsy and paroxysmal conditions. 2011;3(2):22-27. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)