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Epilepsia and paroxyzmal conditions

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TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS

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Abstract

Epilepsy is the most frequent neurological sign of tuberous sclerosis complex (TSC) and it’s registered in 83.5% of patients. In majority of cases epilepsy begins during the first year of life (63%) and in 38.8% it’s manifesting as infantile spasms. The presence of epilepsy is closely connected with development of mental retardation in TSC. Early treatment of epilepsy is a key to prevention of mental retardation, and preventive treatment with vigabatrin is now advised by some specialists. Possibly high efficasy of vigabatrin in treatment of seizures associated with TSC is partly due to its m-TOR inhibiting property. M-TOR way is widely discussed now as one of the perspective targets for epilepsy treatment, associated or not associated with TSC.

About the Authors

E. D. Belousova
The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation
Russian Federation

MD, Professor, Honored Doctor of the Russian Federation. Department psychoneurology Epileptology, Research Clinical Institute,

ul. Ostrovityanova, 1, Moscow, 117997



M. Y. Dorofeeva
The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation
Russian Federation

PhD, a leading researcher at the Department psychoneurology and Epileptology, Research Clinical Institute,

ul. Ostrovityanova, 1, Moscow, 117997



T. G. Ohapkina
The Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation
Russian Federation

doctor-intern of the Department of Neurology, Neurosurgery and Medical Genetics, Faculty of Pediatrics,

ul. Ostrovityanova, 1, Moscow, 117997



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For citation:


Belousova E.D., Dorofeeva M.Y., Ohapkina T.G. TREATMENT OF EPILEPSY IN TUBEROUS SCLEROSIS. Epilepsia and paroxyzmal conditions. 2016;8(2):37-42. (In Russ.)

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ISSN 2077-8333 (Print)
ISSN 2311-4088 (Online)