EPILEPSY AND PINEAL HORMONE: CURRENT STATE OF THE PROBLEM
Abstract
The pineal gland hormone melatonin is the main regulator of biological rhythms. It affects sleep, brain bioelectric activity and seizures. The majority of experimental and clinical studies are confirmed the anticonvulsant properties of melatonin. However, in the scientific literature there is no data on the concentration of melatonin in adult patients with epilepsy and epileptic syndromes. Thus study of melatonin in adult patients was developed. The evening (1 hour before bedtime), night concentrations (morning), and excretion of melatonin in 54 patients with focal symptomatic epilepsy at the age of 21 to 47 years were evaluated. It was found that seizures provoke a decrease of melatonin concentration.
About the Authors
O. M. Oleynikova
SBEI HPE «RNSMU named after N.I. Pirogov» Ministry of Healthcare and Social Development of Russia
Russian Federation
Russian Federation
E. N. Kareva
SBEI HPE «RNSMU named after N.I. Pirogov» Ministry of Healthcare and Social Development of Russia
Russian Federation
Russian Federation
M. A. Bogomazova
SBEI HPE «RNSMU named after N.I. Pirogov» Ministry of Healthcare and Social Development of Russia
Russian Federation
Russian Federation
G. G. Avakyan
SBEI HPE «RNSMU named after N.I. Pirogov» Ministry of Healthcare and Social Development of Russia
Russian Federation
Russian Federation
Yu. V. Lagutin
SBEI HPE «RNSMU named after N.I. Pirogov» Ministry of Healthcare and Social Development of Russia
Russian Federation
Russian Federation
G. N. Avakyan
SBEI HPE «RNSMU named after N.I. Pirogov» Ministry of Healthcare and Social Development of Russia
Russian Federation
Russian Federation
References
1. Анисимов В. Н. Роль эпифиза (шишковидной железы) в механизмах старения //Успехи геронтологии.- 1998; 2: 74 – 81.
2. Арашунян Э.Б. Эпифизарный гормон мелатонин и неврологическая патология. //РМЖ. Неврология.- 2006 - 14 (23).
3. Гусев Е.И., Бурд Г.С. Эпилепсия. //М.-1994. – С.63.
4. Воронина Т.А., Неробкова Л.Н. Методические указания по изучению противосудорожной активности фармакологических веществ. //Руководство по экспериментальному (доклиническому изучению новых фармакологических веществ. - М.-2005. - С.277-294.
5. Карлов В. А. Эпилепсия у детей и взрослых мужчин и женщин. //Рук. для врачей. - М.: Медицина. – 2010. - 718 с.
6. Мизун Ю.Г. Космос и здоровье. Как уберечь себя и избежать болезней. //М.: Вече, ACT. - 1998. – С.368.
7. Михайленко Ю. Увеличение численности населения Земли до 7 млрд человек должно стать сигналом к действию для всех стран. // ИТАР ТАСС. – 2011.-27/10.
8. Плехова Е.И., Турчина С.И. Годовые и циркадные ритмы экскреции мелатонина у здоровых мальчиков-подростков.// По материалам Третьего международного симпозиума Компании Ново Нордиск (Дания) для врачей - эндокринологов «Проблемы детской эндокринологии» - 17-19 сентября 1998 года.- Крым.- Украина.
9. Ardura J., Andres J., Garmendia J.R., Ardura F. Melatonin in epilepsy and febrile seizures. //J Child Neurol. – 2010.- Jul; 25(7) – P. 888-91. //Epub – 2010.- May 26.
10. Armstrong S.M., Redman J.R. Melatonin: a chronobiotic with anti-aging properties? Med Hypotheses. – 1991. – 34. – Р. 300-309.
11. Bazil C.W., Short D., Crispin D., and Zheng W., “Patients with intractable epilepsy have low melatonin, which increases following seizures.” //Neurology. - Vol. 55, №11. – 2000. - Р. 1746–1748.
12. Bindoni M., Rizzo R. Hipрocampal evoked potentials and convulsive activity after electrolytic lesions of the pineal body in chronic experiments in rabbits. //Arch. Sci. Biol. – 1965. – 49. – Р. 223–233.
13. Breivik N., Reiher T. Epilepsy in children in the Sunnm re //DistrictTidsskr Nor Laegeforen. -2008.- 128(18).-P. 2049-51.
14. Borowicz K.K., Kaminski R., Gasior M. et al. Influence of melatonin upon the protective action of conventional antiepileptic drugs against maximal electroshock in mice. //Eur. Neuropsychopharmacol. – 1999. – 9. – Р. 185–190.
15. Bureau Y.R., Persinger M.A. Geomagnetic activity and enhancement mortality in rats with acute (epileptic) limbic lability //Int J Biometeorol. – 1992. – 36. – 4. - Р.226-232.
16. Connolly MB, Hamilton D, Freeman RD, Laudon M. Melatonin treatment of nonepileptic myoclonus in children. Jan JE. // Dev Med Child Neurol. – 1999. - Apr;41(4). – Р. 255-259.
17. Fariello R.G., Bubenik G.A., Brown G.M. et al., “Epileptogenic action of intraventricularly injected antimelatonin antibody.” //Neurology, vol.27.-1997.-no.6.-Р.267–270.
18. Fauteck J., Schmidt H., Lerchl A., Kurlemann G., and Wittkowski W. “Melatonin in epilepsy: first results of replacement therapy and first clinical results.” //Biological Signals and Receptors. 1999. -Vol. 8, № 1-2. - Р. 105–110.
19. Giusti P., Lipartiti M., Franceschini D. et al. Neuroprotection by melatonin from kainateinduced excitotoxicity in rats //FASEB J. – 1996. – V. 10. – Р. 891-896.
20. Guo J.F. and Yao B.Z., “Serum melatonin levels in children with epilepsy or febrile seizures.” //Zhongguo Dang Dai Er Ke Za Zhi. - 2009- Vol. 11, № 4. - Р. 288–290.
21. Gupta M., Gupta Y.K., Agarwa S., Aneja S., Kalaivani M., and Kohli K., “Effects of addon melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial.” // Epilepsia. - 2004. - Vol. 45, №12. - Р. 1636–1639.
22. Gupta M., Gupta Y.K., Agarwal S., Aneja S., Kohli K.A. randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes. //Br J Clin Pharmacol. – 2004. – Nov.58(5):542-7.
23. Gupta M., Kohli K., Gupta Y.K. Modulation of serum concentrations of melatonin by carbamazepine and valproate. Indian J Physiol Pharmacol. 2006; 50(1): 79-82.
24. Gupta Y.K., Gupta M., Chaudhary G., Kohli K. Modulation of antiepileptic effect of phenytoin and carbamazepine by melatonin in mice. //Methods Find Exp Clin Pharmacol. – 2004. - Mar.26(2):99-102.25. Gupta M., Aneja S., and Kohli K. “Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial.” //Epilepsy and Behavior. - 2004.- Vol. 5, № 3. - Р. 316–321.
25. Lapin I.P., Mirzaev S.M., Ryzov I.V., Oxenkrug G.F. Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. //J Pineal Res. – 1998. - 24:215-218.
26. de Lima E., Soares J.M. Jr., del Carmen Sanabria Garrido Y., Gomes Valente S., Priel M.R., Chada Baracat E., Abrão Cavalheiro E., da Graça Naffah-Mazzacoratti M., Amado D. Effects of pinealectomy and the treatment with melatonin on the temporal lobe epilepsy in rats. //Brain Res. – 2005. - May 10. - 1043(1-2):24-31.
27. Locher W., Faedler M. The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs.VI Seasonal influences on maximal electrochock and PTZ seizure thresholds. // Epilepsy Res. – 1996. - 25(1). - Р. 3-10.
28. Manev H., Tolga U.Z., Kharlamov A., and Joo J.Y. “Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.” //FASEB Journal. – 1996. - Vol. 10, №13. - Р. 1546–1551.
29. Mevissen M., Ehert U. Anticonvulsant effects of melatonin in amygdala-kindled rats. //Neurosci Lett. – 1998. - 257:13-16.
30. Molina-Carballo A., Munoz–Hovos A., Reiter R.J., Sanchez-Forte M. et all, Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience. //J Pineal Res. - 1997 Sep. - 23(2):97-105.
31. Molina-Carballo A., Muñoz-Hoyos A., Sánchez-Forte M., Uberos-Fernández J., F Moreno-Madrid., and Acuña-Castroviejo D. “Melatonin increases following convulsive seizures may be related to its anticonvulsant properties at physiological concentrations.” //Neuropediatrics. - 2007. - Vol. 38, № 3. - Р. 122–125.
32. Muñoz-Hoyos A., Sánchez-Forte M., Molina-Carballo A. et al. “Melatonin' s role as an anticonvulsant and neuronal protector: experimental and clinical evidence.” //Journal of Child Neurology. – 1998. - Vol. 13, № 10. - Р. 501–509.
33. Ostrowska Z. Menopause, obesity, and bone status. //Postepy Hig Med Dosw (Online). – 2009. - Feb 11. - 63:39-46.
34. Paprocka.J., R. Dec, Jamroz E. et al., “Melatonin and childhood refractory epilepsy—a pilot study.” //Medical Science Monitor. – 2010. - Vol. 16, № 9 - Р. 389–396.
35. Peled N., Shorer Z., Peled E., Pillar G. Melatonin effect on seizures in children with severe neurological deficit disorders. //Epilepsia. – 2001. - 42:1208-1210.
36. Persinger M.A. Increased geomagnetic activity and the occurrence of bereavement hallucinations :evidence for melatoninmediated micro seizuring in the temporal lobe //Neurosci Lett. – 1988. - 88,3. - Р.271-274.
37. Quigg.M. Сircadian rhythms:interactions with seizure and epilepsy. //Epilepsy Res. – 2000. – №42. - Р. 43-55.
38. Ribeiro A.S., Felgueira R.M., Guilhoto L.M.F. Seasonal presentation of epileptic seizures in a community Epilepsia. – 2005. - V.4. - S.6. – P. 244.
39. Rohr U.D., Herold J. Melatonin deficiencies in women. //Maturitas. – 2002. - Apr 15.- 41 Suppl 1:S85-104.
40. Romijn H.J. The pineal: a tranquilizing organ? //Life Sci. – 1978. – №23. – Р. 2257-2274.
41. Rudeen P.K., Philo R.C., Symmes S.K. Antiepileptic effects of melatonin in the pinealectomized Mongolian gerbil. // Epilepsia. – 1980. - №21. – Р. 149–154.
42. Sanchez-Forte M., Moreno-Madrid F., Munoz-Hovos A., Molina-Carballo A., Acuna- Castroviejo D., Molina-Font The effect of melatonin as anti-convulsant and neuron protector. //J.A.Rev Neurol. - 1997 Aug. - 25(144):1229-34.
43. Srivastava A.K., Gupta S.K., Jain S., Gupta Y.K. Effect of melatonin and phenytoin on an intracortical ferric chloride model of posttraumatic seizures in rats. //Methods Find Exp Clin Pharmacol. – 2002. - №24. – Р. 145-149.
44. Saracz J. and Rosdy B. “Effect of melatonin on intractable epilepsies.” //The Orvosi Hetilap. – 2004. - Vol. 145. - № 51. - № 2583–2587.
45. Sheldon S. H. “Pro-convulsant effects of oral melatonin in neurologically disabled children.” //The Lancet. – 1998. - Vol. 351, № 9111. - Р. 1254.
46. Stewart L.S. Endogenous melatonin and epileptogenesis:fact and hypothesis. //Int.J. Neurosci. 2001. - №107. - Р.77-85.
47. Stewart L.S., Leung L.S. Hippocampal melatonin receptors modulate seizurethreshold. //Epilepsia. – 2005. – 46. - №4. - Р. 473-480.
48. Yildirim M., Marangoz C. Brain Res. Anticonvulsant effects of melatonin on penicillin- induced epileptiform activity in rats.- 2006 Jul 12. - 1099(1):183-8.
49. Waterhaus E., Towne A., Boggs J. et al.Circadian distribution of status epilepticus. //Epilepsia. – 1996. - 37: Suppl 5: 137.
50. Yamamoto H., Tang H.W. Antagonistic effect of melatonin against cyanide-induced seizures and acute lethality in mice. // Toxicol Lett. – 1996. -№87. – Р.19-24.
For citation:
Oleynikova O.M., Kareva E.N., Bogomazova M.A., Avakyan G.G., Lagutin Y.V., Avakyan G.N. EPILEPSY AND PINEAL HORMONE: CURRENT STATE OF THE PROBLEM. Epilepsy and paroxysmal conditions. 2011;3(4):22-27. (In Russ.)
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